Grading Of Invasive Cribriform Carcinoma On Prostate Needle Biopsy: An Interobserver Study Among Experts In Genitourinary Pathology

dc.creatorLatour M.
dc.creatorAmin M.B.
dc.creatorBillis A.
dc.creatorEgevad L.
dc.creatorGrignon D.J.
dc.creatorHumphrey P.A.
dc.creatorReuter V.E.
dc.creatorSakr W.A.
dc.creatorSrigley J.R.
dc.creatorWheeler T.M.
dc.creatorYang X.J.
dc.creatorEpstein J.I.
dc.date2008
dc.date2015-06-30T19:29:13Z
dc.date2015-11-26T14:44:47Z
dc.date2015-06-30T19:29:13Z
dc.date2015-11-26T14:44:47Z
dc.date.accessioned2018-03-28T21:53:48Z
dc.date.available2018-03-28T21:53:48Z
dc.identifier
dc.identifierAmerican Journal Of Surgical Pathology. , v. 32, n. 10, p. 1532 - 1539, 2008.
dc.identifier1475185
dc.identifier10.1097/PAS.0b013e318169e8fd
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-53449095423&partnerID=40&md5=971cf66d75703a5c0d68ed0dcb734587
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/106433
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/106433
dc.identifier2-s2.0-53449095423
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1252262
dc.descriptionThe distinction between cribriform Gleason pattern 3 and 4 prostate cancer is controversial. Out of 3590 prostate cancers sent to one of the authors over 7 months, 30 needle biopsy cases were selected that possibly represented cribriform Gleason pattern 3 cancer. Thirty-six digital images were taken and sent to 10 experts in prostate pathology. Consensus was defined when at least 7/10 experts agreed on the grade. Sixty-seven percent (n=24) of images reached consensus (23 pattern 4; 1 pattern 3). Of the 12 nonconsensus images, 7 were favor pattern 4 (6/10 experts agreed), 1 was favor pattern 3 (6/10 experts agreed), and 4 were equivocal (<6 experts agreed). The most common criteria used to call pattern 4 in the 23 consensus pattern 4 images were in frequency: irregular contour, irregular distribution of lumens, slit-like lumens, large glands, number of glands, and small lumens. In the only consensus pattern 3 image, criteria used were regular contour, small glands, regular distribution of lumens, and uniform round lumens. Discrepancy between experts was qualified as primarily objective (different criteria present) in 38%, subjective (different interpretation of the same criteria) in 12%, and mixed (both objective and subjective) in 50%. The most frequent situation with different interpretations of the same criteria were regular versus irregular contour and small versus large glands, with the former more common. Even in this highly selected set of images thought to be the best candidates for cribriform pattern 3 from a busy consult service, most experts interpreted the cribriform patterns as pattern 4. Moreover, most of the cribriform foci investigated (73%) were associated with more definitive pattern 4 elsewhere on the needle biopsy specimen. In conclusion, most of the small cribriform cancer foci seen on needle biopsy should be interpreted as Gleason pattern 4 and not pattern 3. © 2008 Lippincott Williams & Wilkins.
dc.description32
dc.description10
dc.description1532
dc.description1539
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dc.languageen
dc.publisher
dc.relationAmerican Journal of Surgical Pathology
dc.rightsfechado
dc.sourceScopus
dc.titleGrading Of Invasive Cribriform Carcinoma On Prostate Needle Biopsy: An Interobserver Study Among Experts In Genitourinary Pathology
dc.typeArtículos de revistas


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