The Use Of Ultrafiltration For Inflammatory Mediators Removal During Cardiopulmonary Bypass In Coronary Artery Bypass Graf Surgery

dc.creatorAntunes N.
dc.creatorDragosavc D.
dc.creatorPetrucci Jr. O.
dc.creatorDe Oliveira P.P.M.
dc.creatorKosour C.
dc.creatorBlotta M.H.S.L.
dc.creatorBraile D.M.
dc.creatorVieira R.W.
dc.date2008
dc.date2015-06-30T19:27:44Z
dc.date2015-11-26T14:44:25Z
dc.date2015-06-30T19:27:44Z
dc.date2015-11-26T14:44:25Z
dc.date.accessioned2018-03-28T21:53:12Z
dc.date.available2018-03-28T21:53:12Z
dc.identifier
dc.identifierBrazilian Journal Of Cardiovascular Surgery. , v. 23, n. 2, p. 175 - 182, 2008.
dc.identifier1027638
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-53049107459&partnerID=40&md5=8c73dd789bc868c5449c9ff4fe22713e
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/106317
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/106317
dc.identifier2-s2.0-53049107459
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1252114
dc.descriptionObjective: To investigate the effectiveness of ultrafiltration in removing inflammatory mediators released by cardiopulmonary bypass and to correlate ultrafiltration with alterations in organic function according to the Sequential Organ Failure Assessment Score. Methods: Forty patients were included and randomized into two groups: "no ultrafiltration" (n=20; Group I) and "ultrafiltration" (n=20; Group II). Activated complement 3 and 4, interleukins 1beta, 6, 8 and tumor necrosis factor alfa were measured prior to anesthesia induction (Time 1), 5 minutes before cardiopulmonary bypass (Time 2), in the ultrafiltrated fluid (Time 3), 30 minutes (Time 4), and 6 (Time 5), 12 (Time 6), 24 (Time 7), 36 (Time 8) and 48 (Time 9) hours following cardiopulmonary bypass. Sequential Organ Failure Assessment Score was evaluated at Time 1, 6 and 9. Statistical significance was established at p ≤ 0.05. Results: In the ultrafiltrated fluid, only tumor necrosis factor alfa levels were detected. Levels of activated complement 3 at Times 5 and 7 and activated complement 4 at Times 5 and 6 were significantly higher in the unfiltered Group, and levels of interleukin 6 were higher in the filtered Group at Times 7 and 8. Interleukins 1beta, 8, tumor necrosis factor alfa, and the Sequential Organ Failure Assessment score were not significantly different between the groups. Conclusions: Ultrafiltration significantly filtered tumor necrosis factor alfa but did not influences serum levels of this cytokine. Ultrafiltration with the type of filter used in this study had no effect in organic dysfunction and should be used only for volemic control in patients undergo cardiopulmonary bypass.
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dc.languageen
dc.publisher
dc.relationBrazilian Journal of Cardiovascular Surgery
dc.rightsaberto
dc.sourceScopus
dc.titleThe Use Of Ultrafiltration For Inflammatory Mediators Removal During Cardiopulmonary Bypass In Coronary Artery Bypass Graf Surgery
dc.typeArtículos de revistas


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