Trimetazidine As Cardioplegia Addictive Without Pre-treatment Does Not Improve Myocardial Protection: Study In A Swine Working Heart Model [trimetazidina Como Aditivo Em Solução Cardioplégica Sem Pré-tratamento Não Traz Proteção Adicional Ao Miocárdio Isquêmico: Estudo Em Modelo Suíno De Coração Isolado]

dc.creatorSilveira Filho L.D.M.
dc.creatorPetrucci Jr. O.
dc.creatorDo Carmo M.R.
dc.creatorDe Oliveira P.P.M.
dc.creatorVilarinho K.A.S.
dc.creatorVieira R.W.
dc.creatorBraile D.M.
dc.date2008
dc.date2015-06-30T19:27:50Z
dc.date2015-11-26T14:44:16Z
dc.date2015-06-30T19:27:50Z
dc.date2015-11-26T14:44:16Z
dc.date.accessioned2018-03-28T21:52:58Z
dc.date.available2018-03-28T21:52:58Z
dc.identifier
dc.identifierBrazilian Journal Of Cardiovascular Surgery. , v. 23, n. 2, p. 224 - 234, 2008.
dc.identifier1027638
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-53049106592&partnerID=40&md5=c2ccc317fd8f6222815e606a2ffaf130
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/106323
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/106323
dc.identifier2-s2.0-53049106592
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1252056
dc.descriptionObjective: The aim of this study is to verify in an isolated working heart swine model if the acute administration of trimetazidine to cardioplegia, without pre=treatment improves heart performance. Methods: Eighteen pairs of swines were used in this working heart model, divided into three groups (n = 6) that underwent regional and global ischemia. Each group was selected to a different treatment: St Thomas cardioplegia (ST), St Thomas enriched with trimetazidine (TMZ) and control group (Co). Data was collected during reperfusion period at 30, 60 and 90 minutes. Hemodinamic parameters such as elastance contractility index (Emax), preload recruitable stroke work relationship (PRSW) and heart "stiffness" (EDPVR) were measured. Other data included coronary flow, lactate, oxygen and glucose consumption. Results were statistically analyzed. Results: All contractility data were not significantly different among three groups. Lactate became constantly higher according to time uniformly in all three groups. Coronary flow, glucose consumption and oxygen consumption presented large variations during time periods but according to treatments showed no statistical differences in all three groups. Left ventricle final weight was significantly lower in trimetazidine group compared to both other groups. Conclusion: Administration of trimetazidine enhanced cardioplegia, without pre-treatment, showed no hemodinamic or metabolic improvement in swine isolated working heart model.
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dc.descriptionDesideri, A., Celegon, L., Metabolic management of ischemic heart disease: Clinical data with trimetazidine (1998) Am J Cardiol, 82 (5 A), pp. 50K-53K
dc.descriptionLavanchy, N., Martin, J., Rossi, A., Anti-ischemic effects of trimetazidine: 31P-NMR spectroscopy in the isolated rat heart (1987) Arch Int Pharmacodyn Ther, 286 (1), pp. 97-110
dc.descriptionBelardinelli, R., Trimetazidine and the contractile response of dysfunctional myocardium in ischaemic cardiomiopathy (2000) Rev Port Cardiol, 19 (SUPPL. 5), pp. V35-V39
dc.descriptionKnight, C., Fox, K., From antianginal drugs to myocardial cytoprotective agents (1995) Am J Cardiol, 76 (6), pp. 4B-7B
dc.descriptionStanley, W.C., Changes in cardiac metabolism: A critical step from stable angina to ischaemic cardiomiopathy (2001) Eur Heart J, 3 (SUPPL.), pp. 2-7
dc.descriptionFabiani, J.N., Ponzio, O., Emerit, I., Massonet-Castel, S., Paris, M., Chevalier, P., Cardioprotective effect of trimetazidine during coronary artery graft surgery (1992) J Cardiovasc Surg, 33 (4), pp. 486-491
dc.descriptionVedrinne, J.M., Vedrinne, C., Bompard, D., Lehot, J.J., Boissel, J.P., Champsaur, G., Myocardial protection during coronary artery bypass graft surgery: A randomized, double-blind, placebo-controlled study with trimetazidine (1996) Anaesth Analg, 82 (4), pp. 712-718
dc.descriptionTünerir, B., Colak, O., Alatas, O., Besogul, Y., Kural, T., Aslan, R., Measurement of troponin T to detect cardioprotective effect of trimetazidine during coronary artery bypass grafting (1999) Ann Thorac Surg, 68 (6), pp. 2173-2176
dc.descriptionColégio Brasileiro de Experimentação Animal. Princípios éticos na experimentação animal. In: São Paulo:Congresso do Colégio Brasileiro de Experimentaç ão Animal
dc.description1991Budrikis, A., Bolys, R., Liao, Q., Ingemansson, R., Sjöberg, T., Steen, S., Function of adult pig hearts after 2 and 12 hours of cold cardioplegic preservation (1998) Ann Thorac Surg, 66 (1), pp. 73-78
dc.descriptionBrooks, W.W., Healey, N.A., Sen, S., Conrad, C.H., Bing, O.H., Oxygen cost of stress development in hypertrophied and failing hearts from the spontaneously hypertensive rat (1993) Hypertension, 21 (1), pp. 56-64
dc.descriptionPetrucci Jr O. Estudo comparativo entre solução cardioplégica cristalóide e microcardioplegia sanguínea normotérmica em corações agudamente isquêmicos [Tese de Doutorado]. Campinas:Universidade Estadual de Campinas;2004Detry, J.M., Leclercq, P.J., Trimetazidine European Multicenter Study versus propranolol in stable angina pectoris: Contribution of Holter electrocardiographic ambulatory monitoring (1995) Am J Cardiol, 76 (6), pp. 8B-11B
dc.descriptionMarzilli, M., Klein, W.W., Efficacy and tolerability of trimetazidine in stable angina: A meta-analysis of randomized, double-blind, controlled trials (2003) Coron Artery Dis, 14 (2), pp. 171-179
dc.descriptionCesar, L.A.M., Dallan, L.A., Gowdak, L.H.W., Lisboa, L.A.F., Moretti, M.A., Alternatives for the treatment of angina pectoris: New drugs, external counterpulsation, spinal-cord stimulation for analgesia, therapeutic angiogenisis and transmyocardial revascularization (2003) Rev Soc Cardiol Estado de São Paulo, 13 (2), pp. 240-253
dc.descriptionBraile, D.M., Cardioplegia sanguínea isotérmica anterógrada e retrógrada de baixo volume (1997) São José do Rio Preto
dc.descriptionHerrmann, J.L.V., Stefanini, E., Drug therapy. Choosing the best schedule (2003) Rev Soc Cardiol Estado de São Paulo, 13 (2), pp. 196-203
dc.descriptionStanley, W.C., Cardiac energetics during ischemia and the rationale for metabolic interventions (2001) Coron Artery Dis, 12 (SUPPL. 1), pp. 53-57
dc.descriptionPichon, G., Rousseau, D., Helies, C., Control by Trimetazidine of the energy substrate balance in ventricular myocite (1999) J Moll Cell Cardiol, 31, pp. A88
dc.descriptionRodrigues, A.J., Vicente, W.V.A., Carneiro, J.J., Bassetto, S., Cardioplegia sanguínea anterógrada intermitente normotérmica e hipotérmica: Estudo comparativo em corações agudamente isquêmicos de coelhos. (2000) Rev Bras Cir Cardiovasc, 15 (3), pp. 238-250
dc.descriptionRodrigues, A.J., Sader, A.A., Vicente, W.V.A., Bassetto, S., Cardioplegia sanguínea normotérmica intermitente anterógrada. II. Com e sem aminoácidos: Estudo comparativo em coelhos. (1997) Rev Bras Cir Cardiovasc, 12 (4), pp. 340-347
dc.descriptionHorsley, W.S., Whitlark, J.D., Hall, J.D., Gott, J.P., Huang, P.-C.A.H., Revascularization for acute regional infarct: Superior protection with warm blood cardioplegia (1993) Ann Thorac Surg, 56 (6), pp. 1228-1237
dc.descriptionGrossman, W., Braunwald, E., Mann, T., McLaurin, L.P., Green, L.H., Contractile state of the left ventricle in man as evaluated from end-systolic pressure-volume relations (1977) Circulation, 56 (5), pp. 845-852
dc.descriptionGlower, D.D., Spratt, J.A., Snow, N.D., Kabas, J.S., Davis, J.W., Olsen, C.O., Linearity of the Frank-Starling relationship in the intact heart: The concept of preload recruitable stroke work (1985) Circulation, 71, pp. 994-1009
dc.descriptionGuyton RA. A synopsis of cardiac physiology. In: Edmunds LH. Cardiac surgery in the adult. 1st ed. New York:McGrawHill Companies;1997. p.59-84Petrucci Júnior, O., Oliveira, P.P., Carmo, M.R., Vieira, R.W., Braile, D.M., Standardization of an isolated pig heart preparation with parabiotic circulation: Methodological considerations (2003) Braz J Med Biol Res, 36 (5), pp. 649-659
dc.descriptionAllibardi, S., Chierchia, S.L., Margonato, V., Merati, G., Neri, G., Dell'Antonio, G., Effects of trimetazidine on metabolic and functional recovery of postischemic rat hearts (1998) Cardiovasc Drugs Ther, 12 (6), pp. 543-549
dc.descriptionKantor, P.F., Lucien, A., Kozak, R., Lopaschuk, G.D., The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase (2000) Circ Res, 86 (5), pp. 580-588
dc.descriptionKober, G., Buck, T., Sievert, H., Vallbracht, C., Myocardial protection during percutaneous transluminal coronary angioplasty: Effects of trimetazidine (1992) Eur Heart J, 13 (8), pp. 1109-1115
dc.descriptionBeygui, F., Trimetazidine as adjunctive therapy to primary PTCA for acute myocardial infarction (2000) Rev Port Cardiol, 19 (SUPPL. 5), pp. V31-V34
dc.descriptionSteg, P.G., Grollier, G., Gallay, P., Morice, M., Karrillon, G.J., Benamer, H., A randomized double-blind trial of intravenous trimetazidine as adjunctive therapy to primary angioplasty for acute myocardial infarction (2001) Int J Cardiol, 77 (2-3), pp. 263-273
dc.descriptionGroup. Effect of 48-h intravenous trimetazidine on short- and long-term outcomes of patients with acute myocardial infarction, with and without thrombolitic therapy
dc.descriptionA double-blind, placebo-controlled, randomized trial. The EMIP-FR Group. European Myocardial Infarction Project-Free Radicals (2000) Eur Heart J, 21 (18), pp. 1537-1546. , The European Myocardial Infarction Project-Free Radicals EMIP-FR
dc.descriptionGrynberg, A., The EMIP-FR Study: The evolution of scientific background as a non-controlled parameter (2001) Eur Heart J, 22 (11), pp. 975-977
dc.descriptionIkizler, M., Erkasap, N., Dernek, S., Batmaz, B., Kural, T., Kaygisiz, Z., Trimetazidine-induced enhancement of myocardial recovery during reperfusion: A comparative study in diabetic and non-diabetic rat hearts (2006) Arch Med Res, 37 (6), pp. 700-708
dc.descriptionIkizler, M., Dernek, S., Sevin, B., Kural, T., Trimetazidine improves recovery during reperfusion in isolated rat hearts after prolonged ischemia (2003) Anadolu Kardiyol Derg, 3 (4), pp. 303-308
dc.descriptionOnay-Besikci, A., Guner, S., Arioglu, E., Ozakca, I., Ozcelikay, A.T., Altan, V.M., The effects of chronic trimetazidine treatment on mechanical function and fatty acid oxidation in diabetic rat hearts (2007) Can J Physiol Pharmacol, 85 (5), pp. 527-535
dc.languagept
dc.languageen
dc.publisher
dc.relationBrazilian Journal of Cardiovascular Surgery
dc.rightsaberto
dc.sourceScopus
dc.titleTrimetazidine As Cardioplegia Addictive Without Pre-treatment Does Not Improve Myocardial Protection: Study In A Swine Working Heart Model [trimetazidina Como Aditivo Em Solução Cardioplégica Sem Pré-tratamento Não Traz Proteção Adicional Ao Miocárdio Isquêmico: Estudo Em Modelo Suíno De Coração Isolado]
dc.typeArtículos de revistas


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