Effect Of Bothrops Insularis Venom On The Mouse And Chick Nerve-muscle Preparation

dc.creatorCogo J.C.
dc.creatorPrado-Franceschi J.
dc.creatorCruz-Hofling M.A.
dc.creatorCorrado A.P.
dc.creatorRodrigues-Simioni L.
dc.date1993
dc.date2015-06-30T14:31:50Z
dc.date2015-11-26T14:43:36Z
dc.date2015-06-30T14:31:50Z
dc.date2015-11-26T14:43:36Z
dc.date.accessioned2018-03-28T21:51:49Z
dc.date.available2018-03-28T21:51:49Z
dc.identifier
dc.identifierToxicon. , v. 31, n. 10, p. 1237 - 1247, 1993.
dc.identifier410101
dc.identifier10.1016/0041-0101(93)90397-2
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0027490319&partnerID=40&md5=8b04dc4cad2c23a1460bba7321eaa94b
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/99677
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/99677
dc.identifier2-s2.0-0027490319
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1251752
dc.descriptionJ. C. Cogo, J. Prado-Franceschi, M. A. Cruz-Hofling, A. P. Corrado and L. Rodrigues-Simioni. Effect of Bothrops insularis venom on the mouse and chick nerve-muscle preparation. Toxicon 31, 1237-1247, 1993.-The effects of Bothrops insularis venom were examined in vivo in mice and chicks and in vitro using the mouse phrenic nerve diaphragm and chick biventer cervicis muscle preparations. Incubation of the indirectly or directly stimulated mouse preparation with B. insularis venom (20-80 μg/ml) produced an initial increase in twitch tension followed by irreversible blockade. With direct stimulation in the presence of d-tubocurarine, no increase in twitch tension was observed prior to the onset of blockade. A venom-induced effect on presynaptic activity was suggested by the marked increase in the frequency of the mepps recorded in vitro 5-15 min after venom addition. A direct muscular effect was shown by the dose- and time-dependent reduction in the resting membrane potential of the diaphragm. Chick preparations were more sensitive than those of the mouse. In the isolated chick biventer cervicis muscle preparation, B. insularis venom induced a contracture and a dose-dependent block of responses to indirect stimulation. At low venom concentrations (1-5 μg/ml), no significant release of creatine kinase (CK) was observed from this preparation. However, a dose-dependent release of CK was detected at higher doses (10-80 μg/ml). For morphological studies, B. insularis venom was injected into the chick left pectoralis muscle. At low doses (0.4 μg), only an inflammatory reaction was present, while at high doses (20-80 μg) increasing numbers of necrotic fibers were observed as well as occlusive thrombosis and hemorrhage. The muscular effect, also observed on the incubated muscle, points to a direct myolytic action of the whole venom. © 1993.
dc.description31
dc.description10
dc.description1237
dc.description1247
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dc.languageen
dc.publisher
dc.relationToxicon
dc.rightsfechado
dc.sourceScopus
dc.titleEffect Of Bothrops Insularis Venom On The Mouse And Chick Nerve-muscle Preparation
dc.typeArtículos de revistas


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