Statin Modulates Insulin Signaling And Insulin Resistance In Liver And Muscle Of Rats Fed A High-fat Diet

dc.creatorLalli C.A.
dc.creatorPauli J.R.
dc.creatorPrada P.O.
dc.creatorCintra D.E.
dc.creatorRopelle E.R.
dc.creatorVelloso L.A.
dc.creatorSaad M.J.A.
dc.date2008
dc.date2015-06-30T19:21:11Z
dc.date2015-11-26T14:43:05Z
dc.date2015-06-30T19:21:11Z
dc.date2015-11-26T14:43:05Z
dc.date.accessioned2018-03-28T21:50:59Z
dc.date.available2018-03-28T21:50:59Z
dc.identifier
dc.identifierMetabolism: Clinical And Experimental. , v. 57, n. 1, p. 57 - 65, 2008.
dc.identifier260495
dc.identifier10.1016/j.metabol.2007.07.021
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-36849086456&partnerID=40&md5=988946941a39518be06e1a5922678613
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/105874
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/105874
dc.identifier2-s2.0-36849086456
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1251525
dc.descriptionRecent studies have shown that statins might have relevant effects on insulin resistance in animal models and in humans. However, the molecular mechanisms that account for this improvement in insulin sensitivity are not well established. The aim of the present study was to investigate the effect of a statin on insulin sensitivity and insulin signaling in liver and muscle of rats fed on a high-fat diet (HFD) for 4 weeks, treated or not with lovastatin during the last week. Our data show that treatment with lovastatin results in a marked improvement in insulin sensitivity characterized by an increase in glucose disappearance rate during the insulin tolerance test. This increase in insulin sensitivity was associated with an increase in insulin-induced insulin receptor (IR) tyrosine phosphorylation and, in parallel, a decrease in IR serine phosphorylation and association with PTP1B. Our data also show that lovastatin treatment was associated with an increase in insulin-stimulated insulin receptor substrate (IRS) 1/phosphatidylinositol 3-kinase/Akt pathway in the liver and muscle of HFD-fed rats in parallel with a decrease in the inflammatory pathway (c-jun N-terminal kinase and I kappa β kinase (IKKβ)/inhibitor of κB/nuclear factor κB) related to insulin resistance. In summary, statin treatment improves insulin sensitivity in HFD-fed rats by reversing the decrease in the insulin-stimulated IRS-1/phosphatidylinositol 3-kinase/Akt pathway in liver and muscle. The effect of statins on insulin action is further supported by our findings that HFD rats treated with statin show a reduction in IRS-1 serine phosphorylation, I kappa kinase (IKK)/inhibitor of κB/nuclear factor κB pathway, and c-jun N-terminal kinase activity, associated with an improvement in insulin action. Overall, these results provide important new insight into the mechanism of statin action in insulin sensitivity. © 2008 Elsevier Inc. All rights reserved.
dc.description57
dc.description1
dc.description57
dc.description65
dc.descriptionAvruch, J., Insulin signal transduction through protein kinase cascades (1998) Mol Cell Biochem, 182, pp. 31-48
dc.descriptionSaltiel, A.R., Pessin, J.E., Insulin signaling pathway in time and space (2002) Trends Cell Biol, 12, pp. 65-71
dc.descriptionSaad, M.J., Folli, F., Kahn, J.A., Kahn, C.R., Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats (1993) J Clin Invest, 92, pp. 2065-2072
dc.descriptionBrozinick Jr., J.T., Birnbaum, M.J., Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle (1998) J Biol Chem, 273, pp. 14679-14682
dc.descriptionLee, Y.H., Giraud, J., Davis, R.J., White, M.F., c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade (2003) J Biol Chem, 278, pp. 2896-2902
dc.descriptionWeston, C.R., Lambright, D.G., Davis, R.J., Signal transduction: MAP kinase signaling specificity (2002) Science, 296, pp. 2345-2347
dc.descriptionDavis, R.J., Signal transduction by the c-Jun N-terminal kinase (1999) Biochem Soc Symp, 64, pp. 1-12
dc.descriptionHirosumi, J., Tuncman, G., Chang, L., Gorgun, C.Z., Uysal, K.T., Maeda, K., A central role for JNK in obesity and insulin resistance (2002) Nature, 420, pp. 333-336
dc.descriptionNikulina, M.A., Sandhu, N., Shamim, Z., Andersen, N.A., Oberson, A., Dupraz, P., The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin secreting cell lines (2003) Cytokine, 24, pp. 13-24
dc.descriptionIp, Y.T., Davis, R.J., Signal transduction by the c-Jun N-terminal kinase (JNK): from inflammation to development (1998) Curr Opin Cell Biol, 10, pp. 205-219
dc.descriptionAguirre, V., Werner, E.D., Giraud, J., Lee, Y.H., Shoelson, S.E., White, M.F., Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action (2002) J Biol Chem, 277, pp. 1531-1537
dc.descriptionChopra, M., Galbraith, S., Darnton-Hill, I., A global response to a global problem: the epidemic of overnutrition (2002) Bull World Health Organ, 80, pp. 952-958
dc.descriptionPrada, P.O., Zecchin, H.G., Gasparetti, A.L., Torsoni, M.A., Ueno, M., Hirata, A.E., Western diet modulates insulin signaling, JNK activity and IRS-1ser307 phosphorylation in a tissue-specific fashion (2005) Endocrinology, 146, pp. 1576-1587
dc.descriptionSchoelson, S.E., Lee, J., Yuan, M., Inflammation and the IKKβ/IκB/NFκB axis in obesity and diet-induced insulin resistance (2003) Int J Obes Relat Metab Disord, 27 (SUPPL. 3), pp. S49-S52
dc.descriptionCai, D., Yuan, M., Frantz, D.F., Melandez, P.A., Hansen, L., Lee, J., Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB (2005) Nat Med, 11, pp. 182-190
dc.descriptionItaui, S., Ruderman, N.R., Schmieder, F., Boden, G., Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C and IκB-α (2002) Diabetes, 51, pp. 2205-2211
dc.descriptionGhosh, S., Karin, M., Missing pieces in the NF-κB puzzle (2002) Cell, 109, pp. S81-S96
dc.descriptionEndo, A., Kuroda, M., Tsujita, Y., ML-236A, ML-236B and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium (1976) J Antibiot (Tokyo), 29, pp. 1346-1348
dc.descriptionIstvan, E.S., Deisenhofer, J., Structural mechanism for statin inhibition of HMG-CoA reductase (2001) Science, 292, pp. 1160-1164
dc.descriptionSuzuki, M., Kakuta, H., Takahashi, A., Shimano, H., Tada-lida, K., Yokoo, T., Effects of atorvastatin on glucose metabolism and insulin resistance in KK/Ay mice (2005) J Atheroscler Thromb, 12, pp. 77-84
dc.descriptionWong, V., Stavar, L., Szeto, L., Uffelman, K., Wang, C.-H., Fantus, G., Atorvastatin induces insulin sensitization in Zucker lean and fatty rats (2006) Atherosclerosis, pp. 348-355
dc.descriptionOkada, K., Maeda, N., Kikuchi, K., Tatsukawa, M., Sawayama, Y., Hayashi, J., Pravastatin improves insulin resistance in dyslipidemic patients (2005) J Atheroscler Thromb, 12, pp. 322-329
dc.descriptionHuptas, S., Geiss, H.-C., Otto, C., Parhofer, K.G., Effect of atorvastatin (10 mg/day) on glucose metabolism in patients with metabolic syndrome (2006) Am J Cardiol, 98, pp. 66-69
dc.descriptionLaemmli, U.K., Cleavage of structural proteins during the assembly of head of bacteriophage T4 (1970) Nature, 227, pp. 680-685
dc.descriptionTowbin, H., Staehelin, T., Gordon, J., Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications (1979) Proc Natl Acad Sci U S A, 76, pp. 4350-4354
dc.descriptionBonora, P., Moghetti, C., Zancanaro, M., Cigolini, M., Querena, V., Cacciatori, A., Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies (1989) J Clin Endocrinol Metab, 68, pp. 374-378
dc.descriptionMorgan, C.R., Lazarow, A., Immunoassay of pancreatic and plasma insulin following alloxan injection of rats (1965) Diabetes, 14, pp. 669-671
dc.descriptionPaolisso, G., Barbagallo, M., Petrella, G., Ragno, E., Barbieri, M., Giordano, M., Effects of simvastatin and atorvastatin administration on insulin resistance and respiratory quotient in aged dyslipidemic non-insulin dependent diabetic patients (2000) Atherosclerosis, 150, pp. 121-127
dc.descriptionPaolisso, G., Sgambato, S., De Riu, S., Gambardella, A., Verza, M., Varricchio, M., Simvastatin reduces plasma lipid levels and improves insulin action in elderly, non-insulin dependent diabetics (1991) Eur J Clin Pharmacol, 40, pp. 27-31
dc.descriptionPaniagua, J.A., Lopez-Miranda, J., Escribano, A., Berral, F.J., Marin, C., Bravo, D., Cerivastatin improves insulin sensitivity and insulin secretion in early-state obese type 2 diabetes (2002) Diabetes, 51, pp. 2596-2603
dc.descriptionFarrer, M., Winocour, P.H., Evans, K., Neil, H.A., Laker, M.F., Kesteven, P., Simvastatin in non-insulin dependent diabetes mellitus: effect on serum lipids, lipoproteins and haemostatic measures (1994) Diabetes Res Clin Pract, 23, pp. 111-119
dc.descriptionOhrvall, M., Lithell, H., Johansson, J., Vessby, B., A comparison between the effects of gemfibrozil and simvastatin on insulin sensitivity in patients with non-insulin-dependent diabetes mellitus and hyperlipoproteinemia (1995) Metabolism, 44, pp. 212-217
dc.descriptionYee, A., Majumdar, S.R., Simpson, S.H., McAlister, F.A., Tsuyuki, R.T., Johnson, J.A., Statin use in type 2 diabetes mellitus is associated with a delay in starting insulin (2004) Diabet Med, 9, pp. 962-967
dc.descriptionBollag, G.E., Roth, R.A., Beaudoin, J., Mochly-Rosen, D., Koshl Jr., D.E., Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity (1986) Proc Natl Acad Sci U S A, 83, pp. 5822-5824
dc.descriptionRosenzweig, T., Braiman, L., Bak, A., Alt, A., Kuroki, T., Sampson, S.R., Differential effects of tumor necrosis factor alpha on protein kinase C isoforms and mediate inhibition of insulin receptor signaling (2002) Diabetes, 51, pp. 1921-1930
dc.descriptionAraújo, E.P., De, C., Souza, T., Gasparetti, A.L., Ueno, M., Boschero, A.C., Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity (2005) Endocrinology, 146, pp. 1428-1437
dc.descriptionHirata, A.E., Alvarez-Rojas, F., Carvalheira, J.B., Carvalho, C.R., Dolnikoff, M.S., Abdalla Saad, M.J., Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats (2003) Life Sci, 73, pp. 1369-1381
dc.descriptionContreras, J.L., Smyth, C.A., Bilbao, G., Young, C.J., Thompson, J.A., Eckhoff, D.E., Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets (2002) Transplantation, 74, pp. 1063-1069
dc.descriptionKureishi, Y., Luo, Z., Shiojima, I., Bialik, A., Fulton, D., Lefer, D.J., The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals (2000) Nat Med, 6, pp. 1004-1010
dc.descriptionSaltiel, A.R., Kahn, C.R., Insulin signalling and the regulation of glucose and lipid metabolism (2001) Nature, 414, pp. 799-806
dc.descriptionCross, D.A., Alessi, D.R., Cohen, P., Andjelkovich, M., Hemmings, B.A., Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B (1995) Nature, 378, pp. 785-789
dc.descriptionArnaud, C., Burger, F., Steffens, S., Veillard, N.R., Nguyen, T.H., Trono, D., Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins (2005) Arterioscler Thromb Vasc Biol, 25, pp. 1231-1236
dc.descriptionVan Aelst, L., D'Souza-Schorey, C., Rho GTPases and signaling networks (1997) Genes Dev, 11, pp. 2295-2322
dc.descriptionLiao, J.K., Laufs, U., Pleiotropic effects of statins (2005) Annu Rev Pharmacol Toxicol, 45, pp. 89-118
dc.descriptionMontaner, S., Perona, R., Saniger, L., Lacal, J.C., Activation of serum response factor by RhoA is mediated by the nuclear factor-κB and C/EBP transcription factors (1999) J Biol Chem, 274, pp. 8506-8515
dc.descriptionPerona, R., Lopez-Miranda, J., Escribano, A., Berral, F.J., Marin, C., Bravo, D., Activation of the nuclear factor-κB by Rho, CDC42, and Rac-1 proteins (1997) Genes Dev, 11, pp. 463-475
dc.descriptionWagner, A.H., Gebauer, M., Guldenzoph, B., Hecker, M., 3-Hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells (2002) Arterioscler Thromb Vasc Biol, 22, pp. 1784-1789
dc.descriptionDichtl, W., Dulak, J., Erick, M., Alber, H.F., Schwarzacher, S.P., Ares, M.P., HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells (2003) Arterioscler Thromb Vasc Biol, 23, pp. 58-63
dc.descriptionMaddux, B.A., Chang, Y.N., Accili, D., McGuinness, O.P., Youngren, J.F., Goldfine, I.D., Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia (2006) Am J Physiol Endocrinol Metab, 290, pp. E746-E749
dc.descriptionCarvalho-Filho, M.A., Ueno, M., Hirabara, S.M., Seabra, A.B., Carvalheira, J.B., de Oliveira, M.G., S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance (2005) Diabetes, 54, pp. 959-967
dc.descriptionPender, C., Goldfine, I.D., Kulp, J.L., Tanner, C.J., Maddux, B.A., MacDonald, K.G., Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects (2005) Metabolism, 54, pp. 598-603
dc.languageen
dc.publisher
dc.relationMetabolism: Clinical and Experimental
dc.rightsfechado
dc.sourceScopus
dc.titleStatin Modulates Insulin Signaling And Insulin Resistance In Liver And Muscle Of Rats Fed A High-fat Diet
dc.typeArtículos de revistas


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