Immunosurveillance By T-lymphocytes In Pretumoral Stages Of Chemically Induced Pancreatic Carcinogenesis

dc.creatorUbirajara-Garcia I.
dc.creatorEscribano M.J.
dc.date1992
dc.date2015-06-30T14:21:07Z
dc.date2015-11-26T14:42:54Z
dc.date2015-06-30T14:21:07Z
dc.date2015-11-26T14:42:54Z
dc.date.accessioned2018-03-28T21:50:47Z
dc.date.available2018-03-28T21:50:47Z
dc.identifier
dc.identifierCancer Letters. , v. 67, n. 1, p. 79 - 86, 1992.
dc.identifier3043835
dc.identifier10.1016/0304-3835(92)90011-J
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0026564286&partnerID=40&md5=8daf0c74b4d5399d145ccdb444651b69
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/99445
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/99445
dc.identifier2-s2.0-0026564286
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1251471
dc.descriptionCellular immune-response during pancreatic carcinogenesis induced by N-nitroso-bis(2-hydroxy-propyl)amine in Syrian Golden hamsters was studied using a mouse antiserum to hamster T-lymphocytes in indirect immunofluorescence. The chronology of lesions in this model is, acinar cell atypia, cystadenoma, ductal hyperplasia and adenocar-cinoma. Lymphocyte infiltration began before microscopic lesions. Starting as an interstitial and interlobular migration, this earliest population was composed of various kind of mononuclear cells including T-cells. As pancreatic lesions proceeded, an abundant lymphocyte supply through newly formed capillaries (angiogenesis), gave rise to inter- and intralobular nodules composed almost exclusively of T-cells. Migrating from nodules, T-cells invaded and readily destroyed the exocrine tissue. Formation of hyperplastic ducts and of adenocarcinoma was accompanied by considerable accretion of the basal membrane (fibrosis). T-cells were located outside and around this basal membrane so that they never invaded the ductal epithelium. Our results suggest there is an effective immunosurveillance in the early stages of transformation that becomes ineffective at later stages as a consequence of T-cells' inability to pass through the basal membrane barrier surrounding the ductal epithelium in preneoplasic lesions (ductal hyperplasia) and in adenocarcinoma. Extending our observations to human pancreatic cancer could provide a new insight in cellular immunosurveillance and, as a consequence might, help cellular immunotherapeutic approaches for this almost fatal disease. © 1992.
dc.description67
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dc.languageen
dc.publisher
dc.relationCancer Letters
dc.rightsfechado
dc.sourceScopus
dc.titleImmunosurveillance By T-lymphocytes In Pretumoral Stages Of Chemically Induced Pancreatic Carcinogenesis
dc.typeArtículos de revistas


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