Influence Of Aerobic Exercise Training On Cardiovascular And Endocrine-inflammatory Biomarkers In Hypertensive Postmenopausal Women

dc.creatorJarrete A.P.
dc.creatorNovais I.P.
dc.creatorNunes H.A.
dc.creatorPuga G.M.
dc.creatorDelbin M.A.
dc.creatorZanesco A.
dc.date2014
dc.date2015-06-25T17:56:02Z
dc.date2015-11-26T14:42:20Z
dc.date2015-06-25T17:56:02Z
dc.date2015-11-26T14:42:20Z
dc.date.accessioned2018-03-28T21:49:51Z
dc.date.available2018-03-28T21:49:51Z
dc.identifier
dc.identifierJournal Of Clinical And Translational Endocrinology. Elsevier, v. 1, n. 3, p. 108 - 114, 2014.
dc.identifier22146237
dc.identifier10.1016/j.jcte.2014.07.004
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84906857656&partnerID=40&md5=8f7a91d7a5dc1e06e055777a43e3797b
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86948
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86948
dc.identifier2-s2.0-84906857656
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1251227
dc.descriptionGiven that few studies have examined the interaction between endocrine-inflammatory mediators and aerobic exercise training in hypertensive postmenopausal women, the aim of this study was to investigate whether aerobic exercise training (AET) for twenty-four sessions would alter cortisol, leptin and interleukin-1β (IL-1β) levels. To further analyze endothelium function in response to AET, we also examined redox state as well as NO/cGMP pathway in this population. Eighteen hypertensive postmenopausal women finished this study. AET program consisted of 24 sessions in treadmill, 3 times per week, duration of 30 up to 40 min for each session, for 8 weeks at intensity of 100% of the MLSS according to previous incremental test. Heart rate was monitored in all studied time (resting and during exercise sessions). After 48 h of the last exercise session, blood samples were collected for biochemical analyses (levels of cortisol, leptin, IL-1β, nitrite/nitrate (NOx-), cGMP, malondialdehyde (MDA) and asymmetric dimethylarginine (ADMA); superoxide and catalase activity). We also measured systolic and diastolic blood pressure. A significant reduction in body mass was observed. As expected, systolic and diastolic blood pressure values were significantly reduced after AET in hypertensive women. We also found a marked increase in NOx- levels as well as cGMP concentration in trained women, approximately 37.7 and 30.8%, respectively. No changes in cortisol, leptin, ADMA and IL-1β levels were observed after AET. Similarly, MDA levels and catalase activity were not affected by AET. In contrast, a marked increase in SOD activity was found (86.6%). In conclusion, our findings show that aerobic exercise training for twenty-four sessions promoted a significant reduction in blood pressure by activating NO/cGMP pathway as well as by promoting an up-regulation of SOD activity without changing in cortisol/leptin levels in postmenopausal hypertensive women. © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
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dc.languageen
dc.publisherElsevier
dc.relationJournal of Clinical and Translational Endocrinology
dc.rightsfechado
dc.sourceScopus
dc.titleInfluence Of Aerobic Exercise Training On Cardiovascular And Endocrine-inflammatory Biomarkers In Hypertensive Postmenopausal Women
dc.typeArtículos de revistas


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