Dysregulated Expression Of Neuregulin-1 By Cortical Pyramidal Neurons Disrupts Synaptic Plasticity

dc.creatorAgarwal A.
dc.creatorZhang M.
dc.creatorTrembak-Duff I.
dc.creatorUnterbarnscheidt T.
dc.creatorRadyushkin K.
dc.creatorDibaj P.
dc.creatorMartins de Souza D.
dc.creatorBoretius S.
dc.creatorBrzozka M.M.
dc.creatorSteffens H.
dc.creatorBerning S.
dc.creatorTeng Z.
dc.creatorGummert M.N.
dc.creatorTantra M.
dc.creatorGuest P.C.
dc.creatorWillig K.I.
dc.creatorFrahm J.
dc.creatorHell S.W.
dc.creatorBahn S.
dc.creatorRossner M.J.
dc.creatorNave K.-A.
dc.creatorEhrenreich H.
dc.creatorZhang W.
dc.creatorSchwab M.H.
dc.date2014
dc.date2015-06-25T17:55:58Z
dc.date2015-11-26T14:42:19Z
dc.date2015-06-25T17:55:58Z
dc.date2015-11-26T14:42:19Z
dc.date.accessioned2018-03-28T21:49:49Z
dc.date.available2018-03-28T21:49:49Z
dc.identifier
dc.identifierCell Reports. Elsevier, v. 8, n. 4, p. 1130 - 1145, 2014.
dc.identifier22111247
dc.identifier10.1016/j.celrep.2014.07.026
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84908356739&partnerID=40&md5=b05330f8c8bde1e9492c58d023c1b397
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86931
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86931
dc.identifier2-s2.0-84908356739
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1251216
dc.descriptionNeuregulin-1 (NRG1) gene variants are associated with increased genetic risk for schizophrenia. It is unclear whether risk haplotypes cause elevated ordecreased expression of NRG1 in the brains of schizophrenia patients, given that both findings have been reported from autopsy studies. To study NRG1 functions invivo, we generated mouse mutants with reduced and elevated NRG1 levels and analyzed the impact on cortical functions. Loss of NRG1 from cortical projection neurons resulted in increased inhibitory neurotransmission, reduced synaptic plasticity, and hypoactivity. Neuronal overexpression of cysteine-rich domain (CRD)-NRG1, the major brain isoform, caused unbalanced excitatory-inhibitory neurotransmission, reduced synaptic plasticity, abnormal spine growth, altered steady-state levels of synaptic plasticity-related proteins, and impaired sensorimotor gating. We conclude that an "optimal" level of NRG1 signaling balances excitatory and inhibitory neurotransmission in the cortex. Our data provide a potential pathomechanism for impaired synaptic plasticity and suggest that human NRG1 risk haplotypes exert a gain-of-function effect. © 2014 The Authors.
dc.description8
dc.description4
dc.description1130
dc.description1145
dc.descriptionAgarwal, A., Dibaj, P., Kassmann, C.M., Goebbels, S., Nave, K.A., Schwab, M.H., Invivo imaging and noninvasive ablation of pyramidal neurons in adult NEX-CreERT2 mice (2012) Cereb. Cortex, 22, pp. 1473-1486
dc.descriptionAyalew, M., Le-Niculescu, H., Levey, D.F., Jain, N., Changala, B., Patel, S.D., Winiger, E., Amdur, R., Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction (2012) Mol. Psychiatry, 17, pp. 887-905
dc.descriptionBerning, S., Willig, K.I., Steffens, H., Dibaj, P., Hell, S.W., Nanoscopy in a living mouse brain (2012) Science, 335, p. 551
dc.descriptionBertram, I., Bernstein, H.G., Lendeckel, U., Bukowska, A., Dobrowolny, H., Keilhoff, G., Kanakis, D., Bogerts, B., Immunohistochemical evidence for impaired neuregulin-1 signaling in the prefrontal cortex in schizophrenia and in unipolar depression (2007) Ann. N Y Acad. Sci., 1096, pp. 147-156
dc.descriptionBrinkmann, B.G., Agarwal, A., Sereda, M.W., Garratt, A.N., Müller, T., Wende, H., Stassart, R.M., Velanac, V., Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system (2008) Neuron, 59, pp. 581-595
dc.descriptionBrzózka, M.M., Radyushkin, K., Wichert, S.P., Ehrenreich, H., Rossner, M.J., Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain (2010) Biol. Psychiatry, 68, pp. 33-40
dc.descriptionCahill, M.E., Remmers, C., Jones, K.A., Xie, Z., Sweet, R.A., Penzes, P., Neuregulin1 signaling promotes dendritic spine growth through kalirin (2013) J.Neurochem., 126, pp. 625-635
dc.descriptionCarraway, K.L., Weber, J.L., Unger, M.J., Ledesma, J., Yu, N., Gassmann, M., Lai, C., Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases (1997) Nature, 387, pp. 512-516
dc.descriptionChen, Y.J., Johnson, M.A., Lieberman, M.D., Goodchild, R.E., Schobel, S., Lewandowski, N., Rosoklija, G., Small, S., Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit components (2008) J.Neurosci., 28, pp. 6872-6883
dc.descriptionChen, Y.J., Zhang, M., Yin, D.M., Wen, L., Ting, A., Wang, P., Lu, Y.S., Wu, C.Y., ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation (2010) Proc. Natl. Acad. Sci. USA, 107, pp. 21818-21823
dc.descriptionCooper, M.A., Koleske, A.J., Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex (2014) J.Comp. Neurol., 522, pp. 3351-3362
dc.descriptionDeakin, I.H., Nissen, W., Law, A.J., Lane, T., Kanso, R., Schwab, M.H., Nave, K.A., Harrison, P.J., Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiation (2012) Cereb. Cortex, 22, pp. 1520-1529
dc.descriptionDel Pino, I., García-Frigola, C., Dehorter, N., Brotons-Mas, J.R., Alvarez-Salvado, E., Martínez de Lagrán, M., Ciceri, G., Dierssen, M., Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes (2013) Neuron, 79, pp. 1152-1168
dc.descriptionDeutsch, S.I., Rosse, R.B., Mastropaolo, J., Behavioral approaches to the functional assessment of NMDA-mediated neural transmission in intact mice (1997) Clin. Neuropharmacol., 20, pp. 375-384
dc.descriptionDodd, P.R., Hardy, J.A., Oakley, A.E., Edwardson, J.A., Perry, E.K., Delaunoy, J.P., A rapid method for preparing synaptosomes: comparison, with alternative procedures (1981) Brain Res., 226, pp. 107-118
dc.descriptionFalls, D.L., Neuregulins: functions, forms, and signaling strategies (2003) Exp. Cell Res., 284, pp. 14-30
dc.descriptionFazzari, P., Paternain, A.V., Valiente, M., Pla, R., Luján, R., Lloyd, K., Lerma, J., Rico, B., Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling (2010) Nature, 464, pp. 1376-1380
dc.descriptionFlames, N., Long, J.E., Garratt, A.N., Fischer, T.M., Gassmann, M., Birchmeier, C., Lai, C., Marín, O., Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1 (2004) Neuron, 44, pp. 251-261
dc.descriptionGorski, J.A., Talley, T., Qiu, M., Puelles, L., Rubenstein, J.L., Jones, K.R., Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage (2002) J.Neurosci., 22, pp. 6309-6314
dc.descriptionGu, Z., Jiang, Q., Fu, A.K., Ip, N.Y., Yan, Z., Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex (2005) J.Neurosci., 25, pp. 4974-4984
dc.descriptionHahn, C.G., Wang, H.Y., Cho, D.S., Talbot, K., Gur, R.E., Berrettini, W.H., Bakshi, K., Siegel, S.J., Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia (2006) Nat. Med., 12, pp. 824-828
dc.descriptionHering, H., Sheng, M., Dendritic spines: structure, dynamics and regulation (2001) Nat. Rev. Neurosci., 2, pp. 880-888
dc.descriptionHirrlinger, P.G., Scheller, A., Braun, C., Quintela-Schneider, M., Fuss, B., Hirrlinger, J., Kirchhoff, F., Expression of reef coral fluorescent proteins in the central nervous system of transgenic mice (2005) Mol. Cell. Neurosci., 30, pp. 291-303
dc.descriptionHuang, Y.Z., Won, S., Ali, D.W., Wang, Q., Tanowitz, M., Du, Q.S., Pelkey, K.A., Mei, L., Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses (2000) Neuron, 26, pp. 443-455
dc.descriptionJiang, L., Emmetsberger, J., Talmage, D.A., Role, L.W., Type III neuregulin 1 is required for multiple forms of excitatory synaptic plasticity of mouse cortico-amygdala circuits (2013) J.Neurosci., 33, pp. 9655-9666
dc.descriptionKwon, O.B., Longart, M., Vullhorst, D., Hoffman, D.A., Buonanno, A., Neuregulin-1 reverses long-term potentiation at CA1 hippocampal synapses (2005) J.Neurosci., 25, pp. 9378-9383
dc.descriptionLaw, A.J., Lipska, B.K., Weickert, C.S., Hyde, T.M., Straub, R.E., Hashimoto, R., Harrison, P.J., Weinberger, D.R., Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease (2006) Proc. Natl. Acad. Sci. USA, 103, pp. 6747-6752
dc.descriptionLi, L., Cleary, S., Mandarano, M.A., Long, W., Birchmeier, C., Jones, F.E., The breast proto-oncogene, HRGalpha regulates epithelial proliferation and lobuloalveolar development in the mouse mammary gland (2002) Oncogene, 21, pp. 4900-4907
dc.descriptionLi, D., Collier, D.A., He, L., Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia (2006) Hum. Mol. Genet., 15, pp. 1995-2002
dc.descriptionLi, K.X., Lu, Y.M., Xu, Z.H., Zhang, J., Zhu, J.M., Zhang, J.M., Cao, S.X., Luo, J.H., Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy (2012) Nat. Neurosci., 15, pp. 267-273
dc.descriptionLiu, X., Bates, R., Yin, D.M., Shen, C., Wang, F., Su, N., Kirov, S.A., Mei, L., Specific regulation of NRG1 isoform expression by neuronal activity (2011) J.Neurosci., 31, pp. 8491-8501
dc.descriptionMartins-de-Souza, D., Menezes de Oliveira, B., dos Santos Farias, A., Horiuchi, R.S., Crepaldi Domingues, C., de Paula, E., Marangoni, S., Camillo Novello, J., The use of ASB-14 in combination with CHAPS is the best for solubilization of human brain proteins for two-dimensional gel electrophoresis (2007) Brief. Funct. Genomic Proteomic, 6, pp. 70-75
dc.descriptionMata, I., Perez-Iglesias, R., Roiz-Santiañez, R., Tordesillas-Gutierrez, D., Gonzalez-Mandly, A., Vazquez-Barquero, J.L., Crespo-Facorro, B., A neuregulin 1 variant is associated with increased lateral ventricle volume in patients with first-episode schizophrenia (2009) Biol. Psychiatry, 65, pp. 535-540
dc.descriptionMeyer, D., Birchmeier, C., Multiple essential functions of neuregulin in development (1995) Nature, 378, pp. 386-390
dc.descriptionMeyer, A.H., Katona, I., Blatow, M., Rozov, A., Monyer, H., Invivo labeling of parvalbumin-positive interneurons and analysis of electrical coupling in identified neurons (2002) J.Neurosci., 22, pp. 7055-7064
dc.descriptionMichailov, G.V., Sereda, M.W., Brinkmann, B.G., Fischer, T.M., Haug, B., Birchmeier, C., Role, L., Nave, K.A., Axonal neuregulin-1 regulates myelin sheath thickness (2004) Science, 304, pp. 700-703
dc.descriptionMiles, R., Tóth, K., Gulyás, A.I., Hájos, N., Freund, T.F., Differences between somatic and dendritic inhibition in the hippocampus (1996) Neuron, 16, pp. 815-823
dc.descriptionMinichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Klein, R., Essential role for TrkB receptors in hippocampus-mediated learning (1999) Neuron, 24, pp. 401-414
dc.descriptionMizoguchi, A., Ueda, T., Ikeda, K., Shiku, H., Mizoguti, H., Takai, Y., Localization and subcellular distribution of cellular ras gene products in rat brain (1989) Brain Res. Mol. Brain Res., 5, pp. 31-44
dc.descriptionMizuno, K., Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation (2013) Cell. Signal., 25, pp. 457-469
dc.descriptionNatt, O., Watanabe, T., Boretius, S., Radulovic, J., Frahm, J., Michaelis, T., High-resolution 3D MRI of mouse brain reveals small cerebral structures invivo (2002) J.Neurosci. Methods, 120, pp. 203-209
dc.descriptionNave, K.A., Salzer, J.L., Axonal regulation of myelination by neuregulin 1 (2006) Curr. Opin. Neurobiol., 16, pp. 492-500
dc.descriptionNeddens, J., Buonanno, A., Selective populations of hippocampal interneurons express ErbB4 and their number and distribution is altered in ErbB4 knockout mice (2010) Hippocampus, 20, pp. 724-744
dc.descriptionOzaki, M., Sasner, M., Yano, R., Lu, H.S., Buonanno, A., Neuregulin-beta induces expression of an NMDA-receptor subunit (1997) Nature, 390, pp. 691-694
dc.descriptionPenzes, P., Cahill, M.E., Jones, K.A., VanLeeuwen, J.E., Woolfrey, K.M., Dendritic spine pathology in neuropsychiatric disorders (2011) Nat. Neurosci., 14, pp. 285-293
dc.descriptionPitcher, G.M., Beggs, S., Woo, R.S., Mei, L., Salter, M.W., ErbB4 is a suppressor of long-term potentiation in the adult hippocampus (2008) Neuroreport, 19, pp. 139-143
dc.descriptionPitcher, G.M., Kalia, L.V., Ng, D., Goodfellow, N.M., Yee, K.T., Lambe, E.K., Salter, M.W., Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors (2011) Nat. Med., 17, pp. 470-478
dc.descriptionRole, L.W., Talmage, D.A., Neurobiology: new order for thought disorders (2007) Nature, 448, pp. 263-265
dc.descriptionShamir, A., Kwon, O.B., Karavanova, I., Vullhorst, D., Leiva-Salcedo, E., Janssen, M.J., Buonanno, A., The importance of the NRG-1/ErbB4 pathway for synaptic plasticity and behaviors associated with psychiatric disorders (2012) J.Neurosci., 32, pp. 2988-2997
dc.descriptionStefansson, H., Sigurdsson, E., Steinthorsdottir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Chou, T.T., Neuregulin 1 and susceptibility to schizophrenia (2002) Am. J. Hum. Genet., 71, pp. 877-892
dc.descriptionTan, G.H., Liu, Y.Y., Hu, X.L., Yin, D.M., Mei, L., Xiong, Z.Q., Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons (2012) Nat. Neurosci., 15, pp. 258-266
dc.descriptionTing, A.K., Chen, Y., Wen, L., Yin, D.M., Shen, C., Tao, Y., Liu, X., Mei, L., Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons (2011) J.Neurosci., 31, pp. 15-25
dc.descriptionTrommald, M., Hulleberg, G., Andersen, P., Long-term potentiation is associated with new excitatory spine synapses on rat dentate granule cells (1996) Learn. Mem., 3, pp. 218-228
dc.descriptionUhlhaas, P.J., Singer, W., Abnormal neural oscillations and synchrony in schizophrenia (2010) Nat. Rev. Neurosci., 11, pp. 100-113
dc.descriptionVelanac, V., Unterbarnscheidt, T., Hinrichs, W., Gummert, M.N., Fischer, T.M., Rossner, M.J., Trimarco, A., Willem, M., Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination (2012) Glia, 60, pp. 203-217
dc.descriptionWang, J.Y., Frenzel, K.E., Wen, D., Falls, D.L., Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition (1998) J.Biol. Chem., 273, pp. 20525-20534
dc.descriptionWeickert, C.S., Tiwari, Y., Schofield, P.R., Mowry, B.J., Fullerton, J.M., Schizophrenia-associated HapICE haplotype is associated with increased NRG1 type III expression and high nucleotide diversity (2012) Transl. Psychiatr., 2, pp. e104
dc.descriptionWen, L., Lu, Y.S., Zhu, X.H., Li, X.M., Woo, R.S., Chen, Y.J., Yin, D.M., Vazdarjanova, A., Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons (2010) Proc. Natl. Acad. Sci. USA, 107, pp. 1211-1216
dc.descriptionWoo, R.S., Li, X.M., Tao, Y., Carpenter-Hyland, E., Huang, Y.Z., Weber, J., Neiswender, H., Gassmann, M., Neuregulin-1 enhances depolarization-induced GABA release (2007) Neuron, 54, pp. 599-610
dc.descriptionYin, D.M., Chen, Y.J., Lu, Y.S., Bean, J.C., Sathyamurthy, A., Shen, C., Liu, X., Mei, L., Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1 (2013) Neuron, 78, pp. 644-657
dc.descriptionYin, D.M., Sun, X.D., Bean, J.C., Lin, T.W., Sathyamurthy, A., Xiong, W.C., Gao, T.M., Mei, L., Regulation of spine formation by ErbB4 in PV-positive interneurons (2013) J.Neurosci., 33, pp. 19295-19303
dc.descriptionZhong, C., Du, C., Hancock, M., Mertz, M., Talmage, D.A., Role, L.W., Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors (2008) J.Neurosci., 28, pp. 9111-9116
dc.languageen
dc.publisherElsevier
dc.relationCell Reports
dc.rightsaberto
dc.sourceScopus
dc.titleDysregulated Expression Of Neuregulin-1 By Cortical Pyramidal Neurons Disrupts Synaptic Plasticity
dc.typeArtículos de revistas


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