Arhgap21 Associates With Fak And Pkcζ And Is Redistributed After Cardiac Pressure Overload

dc.creatorBorges L.
dc.creatorBigarella C.L.
dc.creatorBaratti M.O.
dc.creatorCrosara-Alberto D.P.
dc.creatorJoazeiro P.P.
dc.creatorFranchini K.G.
dc.creatorCosta F.F.
dc.creatorSaad S.T.O.
dc.date2008
dc.date2015-06-30T19:17:42Z
dc.date2015-11-26T14:41:35Z
dc.date2015-06-30T19:17:42Z
dc.date2015-11-26T14:41:35Z
dc.date.accessioned2018-03-28T21:48:38Z
dc.date.available2018-03-28T21:48:38Z
dc.identifier
dc.identifierBiochemical And Biophysical Research Communications. , v. 374, n. 4, p. 641 - 646, 2008.
dc.identifier0006291X
dc.identifier10.1016/j.bbrc.2008.07.085
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-49449087249&partnerID=40&md5=acbd9d69d9e43cd84fce96cdc80fdab6
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/105621
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/105621
dc.identifier2-s2.0-49449087249
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1250911
dc.descriptionARHGAP21 is highly expressed in the heart, which demonstrates activity over Cdc42 and interacts with proteins of the cytoskeleton and adherent junctions. The main cause of cardiac hypertrophy is mechanical stimulus; therefore we analyzed ARHGAP21 expression after acute mechanical stress in the myocardium and its association with FAK and PKCζ. We demonstrated that ARHGAP21 is relocated to Z-lines and costameres after pressure overload, and interacts with PKCζ and FAK in control rats (sham), rats submitted to aortic clamping and spontaneously hypertensive rats (SHR). Co-transfection using ARHGAP21 and PKCζ constructions demonstrated that ARHGAP21 associates with PKCζ-GST and endogenous FAK. Pulldown assay showed that ARHGAP21 binds to the C-terminal region of FAK. Moreover, ARHGAP21 binds to PKCζ phosphorylated on Thr410 in sham and SHR. However, ARHGAP21 only binds to FAK phosphorylated on Tyr925 of SHR. Additionally, PKCζ is phosphorylated by mechanical stimuli. These results suggest that ARHGAP21 may act as a signaling or scaffold protein of FAK and PKCζ signaling pathways, developing an important function during cardiac stress. © 2008 Elsevier Inc. All rights reserved.
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dc.languageen
dc.publisher
dc.relationBiochemical and Biophysical Research Communications
dc.rightsfechado
dc.sourceScopus
dc.titleArhgap21 Associates With Fak And Pkcζ And Is Redistributed After Cardiac Pressure Overload
dc.typeArtículos de revistas


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