Novel Nucleic Acid-based Agents: Sirnas And Mirnas

dc.creatorPereira T.C.
dc.creatorLopes-Cendes I.
dc.date2008
dc.date2015-06-30T19:16:57Z
dc.date2015-11-26T14:41:26Z
dc.date2015-06-30T19:16:57Z
dc.date2015-11-26T14:41:26Z
dc.date.accessioned2018-03-28T21:48:20Z
dc.date.available2018-03-28T21:48:20Z
dc.identifier
dc.identifierCentral Nervous System Agents In Medicinal Chemistry. , v. 8, n. 2, p. 121 - 130, 2008.
dc.identifier18715249
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-45749089615&partnerID=40&md5=4152c7e7f2b5861ed1ec0bd7b6a15190
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/105571
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/105571
dc.identifier2-s2.0-45749089615
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1250836
dc.descriptionA novel class of therapeutic agents based on nucleic acids has emerged and shown very promising pre-clinical results, named small interfering RNAs (siRNAs) and microRNAs (miRNAs). siRNAs are small RNA duplexes capable of silencing undesired (i.e., mutant, exogenous or aberrant) gene expression with high specificity through a mechanism known as RNA interference. These agents have called special attention to neuroscience since they have been used to experimentally treat a variety of neurological diseases with distinct etiologies such as viral, prions, genetic disorders and others. siRNAs have also been used in other scenarios as: drug-receptor blockage, inhibition of pain signaling and regulation of behavior. Although in a very initial stage, miRNAs also promise novel therapeutic approaches. In this review article we intend to introduce clinicians and researchers to the novel field of si- and miRNA-mediated gene silencing strategies, its history, use in cell and animal models, delivery methods, current status and possible applications in future clinical practice. © 2008 Bentham Science Publishers Ltd.
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dc.languageen
dc.publisher
dc.relationCentral Nervous System Agents in Medicinal Chemistry
dc.rightsfechado
dc.sourceScopus
dc.titleNovel Nucleic Acid-based Agents: Sirnas And Mirnas
dc.typeArtículos de revistas


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