Spinal Cord Atrophy Correlates With Disease Duration And Severity In Amyotrophic Lateral Sclerosis

dc.creatorBranco L.M.T.
dc.creatorDe Albuquerque M.
dc.creatorDe Andrade H.M.T.
dc.creatorBergo F.P.G.
dc.creatorNucci A.
dc.creatorFranca Jr. M.C.
dc.date2014
dc.date2015-06-25T17:55:47Z
dc.date2015-11-26T14:41:16Z
dc.date2015-06-25T17:55:47Z
dc.date2015-11-26T14:41:16Z
dc.date.accessioned2018-03-28T21:48:06Z
dc.date.available2018-03-28T21:48:06Z
dc.identifier
dc.identifierAmyotrophic Lateral Sclerosis And Frontotemporal Degeneration. , v. 15, n. 01/02/15, p. 93 - 97, 2014.
dc.identifier21678421
dc.identifier10.3109/21678421.2013.852589
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84895526329&partnerID=40&md5=a66959d466ab7d0de6c2b0dddc920c85
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86909
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86909
dc.identifier2-s2.0-84895526329
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1250771
dc.descriptionOur objective was to investigate spinal cord (SC) atrophy in amyotrophic lateral sclerosis (ALS) patients, and to determine whether it correlates with clinical parameters. Forty-three patients with ALS (25 males) and 43 age- and gender-matched healthy controls underwent MRI on a 3T scanner. We used T1-weighted 3D images covering the whole brain and the cervical SC to estimate cervical SC area and eccentricity at C2/C3 level using validated software (SpineSeg). Disease severity was quantified with the ALSFRS-R and ALS Severity scores. SC areas of patients and controls were compared with a Mann-Whitney test. We used linear regression to investigate association between SC area and clinical parameters. Results showed that mean age of patients and disease duration were 53.1 ± 12.2 years and 34.0 ± 29.8 months, respectively. The two groups were significantly different regarding SC areas (67.8 ± 6.8 mm2; vs. 59.5 ± 8.4 mm2;, p < 0.001). Eccentricity values were similar in both groups (p = 0.394). SC areas correlated with disease duration (r = - 0.585, p < 0.001), ALSFRS-R score (r = 0.309, p = 0.044) and ALS Severity scale (r = 0.347, p = 0.022). In conclusion, patients with ALS have SC atrophy, but no flattening. In addition, SC areas correlated with disease duration and functional status. These data suggest that quantitative MRI of the SC may be a useful biomarker in the disease. © 2014 Informa Healthcare.
dc.description15
dc.description01/02/15
dc.description93
dc.description97
dc.descriptionKiernan, M.C., Vucic, S., Cheah, B.C., Turner, M.R., Eisen, A., Hardiman, O., Amyotrophic lateral sclerosis (2011) Lancet., 377, pp. 942-955
dc.descriptionKraemer, M., Buerger, M., Berlit, P., Diagnostic problems and delay of diagnosis in amyotrophic lateral sclerosis (2010) Clin Neurol Neurosurg., 112, pp. 103-105
dc.descriptionChieia, M.A., Oliveira, A.S., Silva, H.C., Gabbai, A.A., Amyotrophic lateral sclerosis: Considerations on diagnostic criteria (2010) Arq Neuropsiquiatr., 68, pp. 837-842
dc.descriptionRocha, A.J., Maia Jr., A.C.M., Is magnetic resonance imaging a plausible biomarker for upper motor neuron degeneration in amyotrophic lateral sclerosis/primary lateral sclerosis or merely a useful paraclinical tool to exclude mimic syndromes? A critical review of imaging applicability in clinical routine (2012) Arq Neuropsiquiatr., 70, pp. 532-539
dc.descriptionTurner, M.R., Kiernan, M.C., Leigh, P.N., Talbot, K., Biomarkers in amyotrophic lateral sclerosis (2009) Lancet Neurol., 8, pp. 94-109
dc.descriptionTurner, M.R., Grosskreutz, J., Kassubek, J., Abrahams, S., Agosta, F., Benatar, M., Towards a neuroimaging biomar-ker for amyotrophic lateral sclerosis (2011) Lancet Neurol., 10, pp. 400-403
dc.descriptionTurner, M.R., MRI as a frontrunner in the search for amyotrophic lateral sclerosis biomarkers? (2011) Biomark Med., 5, pp. 79-81
dc.descriptionKollewe, K., Korner, S., Dengler, R., Petri, S., Mohammadi, B., Magnetic resonance imaging in amyotrophic lateral sclerosis (2012) Neurol Res Int., 2012, p. 608501. , Epub
dc.descriptionBashat, B.D., Artzi, M., Tarrasch, R., Nefussy, B., Drory, V.E., Aizenstein, O., A potential tool for the diagnosis of ALS based on diffusion tensor imaging (2011) Amyotroph Lateral Scler., 12, pp. 398-405
dc.descriptionAgosta, F., Rocca Mavalsasina, P., Sala, S., Caputo, D., Perini, M., A longitudinal diffusion tension MRI study of the cervical cord and brain in amyotrophic lateral sclerosis patients (2009) J Neurol Neurosurg Psychiatry., 80, pp. 53-55
dc.descriptionValsasina, P., Agosta, F., Benedetti, B., Caputo, D., Perini, M., Salvi, F., Prelle, A., Filippi, M., Diffusion anisotropy of the cervical cord is strictly associated with disability in amyotrophic lateral sclerosis (2007) Journal of Neurology, Neurosurgery and Psychiatry, 78 (5), pp. 480-484. , DOI 10.1136/jnnp.2006.100032
dc.descriptionCohen-Adad, J., Zhao, W., Keil, B., Ratai, E.M., Triantafyllou, C., Lawson, R., 7-T MRI of the spinal cord can detect lateral corticospinal tract abnormality in amyotrophic lateral sclerosis (2013) Muscle Nerve., 47, pp. 760-762
dc.descriptionCarew, J.D., Nair, G., Pineda-Alonso, N., Usher, S., Hu, X., Benatar, M., Magnetic resonance spectroscopy of the cervical cord in amyotrophic lateral sclerosis (2011) Amyotroph Lateral Scler., 12, pp. 185-191
dc.descriptionChevis, C.F., Da Silva, C.B., D'Abreu, A., Lopes-Cendes, I., Cendes, F., Bergo, F.P., Spinal cord atrophy correlates with disability in Friedreich's ataxia (2013) Cerebellum., 12, pp. 43-47
dc.descriptionEl Escorial revisited: Revised criteria for the diagnosis of ALS. A consensus conference held at Airlie House (1998) Worrenton, pp. 2-4. , World Federation of Neurology research group on motor diseases
dc.descriptionCedarbaum, J.M., Stambler, N., Malta, E., Fuller, C., Hilt, D., Thurmond, B., Nakanishi, A., The ALSFRS-R: A revised ALS functional rating scale that incorporates assessments of respiratory function (1999) Journal of the Neurological Sciences, 169 (1-2), pp. 13-21. , DOI 10.1016/S0022-510X(99)00210-5, PII S0022510X99002105
dc.descriptionHillel, A.D., Miller, R.M., Yorkston, K., McDonald, E., Norris, F.H., Konikow, N., Amyotrophic lateral sclerosis severity scale (1989) Neuroepidemiology, 8 (3), pp. 142-150
dc.descriptionBergo, F.P.G., Franca Jr., M.C., Chevis, C.F., Cendes, F., SpineSeg: A segmentation and measurement tool for evaluation of spinal cord atrophy (2012) CISTI'2012 (7a Conferencia Iberica de Sistemas y Tecnologia de Informacion), pp. 400-403. , Madrid Spain, IEEE
dc.descriptionFranca Jr., M.C., D'Abreu, A., Zanardi, V.A., Faria, A.V., Lopes-Cendes, I., Nucci, A., Cendes, F., MRI shows dorsal lesions and spinal cord atrophy in chronic sensory neuronopathies (2008) Journal of Neuroimaging, 18 (2), pp. 168-172. , DOI 10.1111/j.1552-6569.2007.00193.x
dc.descriptionSasaki, S., Iwata, M., Impairment of fast axonal transport in the proximal axons of anterior horn neurons in amyotrophic lateral sclerosis (1996) Neurology, 47 (2), pp. 535-540
dc.descriptionSperfeld, A.-D., Bretschneider, V., Flaith, L., Unrath, A., Hanemann, C.O., Ludolph, A.C., Kassubek, J., MR-pathologic comparison of the upper spinal cord in different motor neuron diseases (2005) European Neurology, 53 (2), pp. 74-77. , DOI 10.1159/000084650
dc.descriptionCohen-Adad, J., El Mendili, M.H., Morizot-Koutlidis, R., Lehéricy, S., Meininger, V., Blancho, S., Involvement of spinal sensory pathway in ALS and specificity of cord atrophy to lower motor neuron degeneration (2013) Amyotroph Lateral Scler Frontotemporal Degener., 14, pp. 30-38
dc.languageen
dc.publisher
dc.relationAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
dc.rightsfechado
dc.sourceScopus
dc.titleSpinal Cord Atrophy Correlates With Disease Duration And Severity In Amyotrophic Lateral Sclerosis
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución