| dc.creator | Simoes G.F. | |
| dc.creator | Benitez S.U. | |
| dc.creator | Oliveira A.L.R. | |
| dc.date | 2014 | |
| dc.date | 2015-06-25T17:55:47Z | |
| dc.date | 2015-11-26T14:40:59Z | |
| dc.date | 2015-06-25T17:55:47Z | |
| dc.date | 2015-11-26T14:40:59Z | |
| dc.date.accessioned | 2018-03-28T21:47:39Z | |
| dc.date.available | 2018-03-28T21:47:39Z | |
| dc.identifier | | |
| dc.identifier | Brain And Behavior. John Wiley And Sons Ltd, v. 4, n. 5, p. 738 - 753, 2014. | |
| dc.identifier | 21623279 | |
| dc.identifier | 10.1002/brb3.250 | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84910032679&partnerID=40&md5=54128428269078db47a9aa5bc065aba0 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/86905 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/86905 | |
| dc.identifier | 2-s2.0-84910032679 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1250660 | |
| dc.description | Background: G-CSF has been shown to decrease inflammatory processes and to act positively on the process of peripheral nerve regeneration during the course of muscular dystrophy. Aims: The aims of this study were to investigate the effects of treatment of G-CSF during sciatic nerve regeneration and histological analysis in the soleus muscle in MDX mice. Methods: Six-week-old male MDX mice underwent left sciatic nerve crush and were G-CSF treated at 7 days prior to and 21 days after crush. Ten and twenty-one days after surgery, the mice were euthanized, and the sciatic nerves were processed for immunohistochemistry (anti-p75NTR and anti-neurofilament) and transmission electron microscopy. The soleus muscles were dissected out and processed for H&E staining and subsequent morphologic analysis. Motor function analyses were performed at 7 days prior to and 21 days after sciatic crush using the CatWalk system and the sciatic nerve index. Results: Both groups treated with G-CSF showed increased p75NTR and neurofilament expression after sciatic crush. G-CSF treatment decreased the number of degenerated and regenerated muscle fibers, thereby increasing the number of normal muscle fibers. Conclusions: The reduction in p75NTR and neurofilament indicates a decreased regenerative capacity in MDX mice following a lesion to a peripheral nerve. The reduction in motor function in the crushed group compared with the control groups may reflect the cycles of muscle degeneration/regeneration that occur postnatally. Thus, G-CSF treatment increases motor function in MDX mice. Nevertheless, the decrease in baseline motor function in these mice is not reversed completely by G-CSF. MDX dystrophic mice present a decreased peripheral nerve regeneration, secondarily to muscle degeneration. G-CSF treatment increases motor function in MDX mice, by increasing axonal regrowth and Schwann cell activity. | |
| dc.description | 4 | |
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| dc.description | 738 | |
| dc.description | 753 | |
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| dc.language | en | |
| dc.publisher | John Wiley and Sons Ltd | |
| dc.relation | Brain and Behavior | |
| dc.rights | fechado | |
| dc.source | Scopus | |
| dc.title | Granulocyte Colony-stimulating Factor (g-csf) Positive Effects On Muscle Fiber Degeneration And Gait Recovery After Nerve Lesion In Mdx Mice | |
| dc.type | Artículos de revistas | |
