Curcumin Conjugates And Metallocomplexes As Lead Compounds For Development Of Anticancer Agents - A Short Review

dc.creatorde Fatima A.
dc.creatorModolo L.V.
dc.creatorNeres A.T.
dc.creatorFerreira C.V.
dc.creatorde Souza A.C.S.
dc.date2008
dc.date2015-06-30T19:15:11Z
dc.date2015-11-26T14:40:26Z
dc.date2015-06-30T19:15:11Z
dc.date2015-11-26T14:40:26Z
dc.date.accessioned2018-03-28T21:46:40Z
dc.date.available2018-03-28T21:46:40Z
dc.identifier
dc.identifierCurrent Bioactive Compounds. , v. 4, n. 3, p. 189 - 199, 2008.
dc.identifier15734072
dc.identifier10.2174/157340708786305934
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-65649109015&partnerID=40&md5=a6fd85b7eef5facb23c992a2c5489830
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/105429
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/105429
dc.identifier2-s2.0-65649109015
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1250400
dc.descriptionThe plant kingdom is a rich source of compounds with anticancer activities. Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] (1) is a secondary metabolite produced by rhizomes of Curcuma longa that has been used for centuries in traditional Medicine in Asia. Anticancer activity is one of the pharmacological properties of curcumin (1) that has been widely explored. Its targets include transcription factors, growth and angiogenesis regulators, apoptosis-related genes, adhesion-related molecules, and cellular signaling molecules. Some curcumin conjugates and metallocomplexes have been synthesized, characterized and evaluated for anticancer activity. In this mini-review, we discuss the mechanism of action by which curcumin (1) inhibits the progression of tumor growth and also the antiproliferative activity of curcumin conjugates and metallocomplexes on human cancer cells. The understanding of how these conjugates and metallocomplexes exert their anticancer activities is essential for future development of effective drugs. © 2008 Bentham Science Publishers Ltd.
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dc.languageen
dc.publisher
dc.relationCurrent Bioactive Compounds
dc.rightsfechado
dc.sourceScopus
dc.titleCurcumin Conjugates And Metallocomplexes As Lead Compounds For Development Of Anticancer Agents - A Short Review
dc.typeArtículos de revistas


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