Neurotoxicity Of Micrurus Altirostris (uruguayan Coral Snake) Venom And Its Neutralization By Commercial Coral Snake Antivenom And Specific Antiserum Raised In Rabbits

dc.creatorDe Abreu V.A.
dc.creatorLeite G.B.
dc.creatorOliveira C.B.
dc.creatorHyslop S.
dc.creatorFurtado M.D.F.D.
dc.creatorSimioni L.R.
dc.date2008
dc.date2015-06-30T19:14:59Z
dc.date2015-11-26T14:40:21Z
dc.date2015-06-30T19:14:59Z
dc.date2015-11-26T14:40:21Z
dc.date.accessioned2018-03-28T21:46:35Z
dc.date.available2018-03-28T21:46:35Z
dc.identifier
dc.identifierClinical Toxicology. , v. 46, n. 6, p. 519 - 527, 2008.
dc.identifier15563650
dc.identifier10.1080/15563650701647405
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-46249106845&partnerID=40&md5=e9fc8ab3ee35908e83c01c24580d3522
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/105412
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/105412
dc.identifier2-s2.0-46249106845
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1250377
dc.descriptionIn this work, we studied the neuromuscular blockade caused by Micrurus altirostris venom (0.1-10 μg/mL) in indirect stimulated chick biventer cervicis and mouse phrenic nerve-diaphragm preparations and the ability of commercial antivenom (Instituto Butantan) and antiserum raised in rabbits to neutralize neurotoxicity and lethality in chicks and mice (LD50 0.042 and 0.255 mg/kg), injected i.m. and i.p., respectively, with venom (5 LD50):antivenom or antiserum mixtures (n = 6) of 1:1-1:2.5-1:5-1:10-1:20. The venom caused a complete and irreversible neuromuscular blockade in both preparations, inhibited the acetylcholine and carbachol contractures, without interfering on KCl response. The neuromuscular blockade was not Ca2+ or temperature-dependent and did not affect the response to direct stimulation. Only a venom:antivenom or antiserum ratio of 1:20 neutralized the neuromuscular blockade in vitro and protected chicks and mice against 5 LD50 of venom. Our results indicated that Micrurus altirostris venom interferes with postsynaptic neurotransmission and that commercial antivenom and rabbit antiserum have low efficacy in neutralizing the neurotoxicity and lethality of this venom. Copyright © Informa Healthcare USA, Inc.
dc.description46
dc.description6
dc.description519
dc.description527
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dc.languageen
dc.publisher
dc.relationClinical Toxicology
dc.rightsfechado
dc.sourceScopus
dc.titleNeurotoxicity Of Micrurus Altirostris (uruguayan Coral Snake) Venom And Its Neutralization By Commercial Coral Snake Antivenom And Specific Antiserum Raised In Rabbits
dc.typeArtículos de revistas


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