Synthesis And Biological Activity Of 6-formyl-oxamniquine Derivative [síntese E Atividade Biológica Do Derivado 6-formil-oxamniquina]

dc.creatorDe Almeida A.E.
dc.creatorDe Souza A.L.R.
dc.creatorAllegretti S.M.
dc.creatorFrezza T.F.
dc.creatorPinto M.C.
dc.creatorFerreira A.G.
dc.creatorMan C.C.
dc.date2008
dc.date2015-06-30T19:13:59Z
dc.date2015-11-26T14:39:52Z
dc.date2015-06-30T19:13:59Z
dc.date2015-11-26T14:39:52Z
dc.date.accessioned2018-03-28T21:45:48Z
dc.date.available2018-03-28T21:45:48Z
dc.identifier
dc.identifierRevista Brasileira De Ciencias Farmaceuticas/brazilian Journal Of Pharmaceutical Sciences. , v. 44, n. 4, p. 749 - 754, 2008.
dc.identifier15169332
dc.identifier10.1590/S1516-93322008000400022
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-59649108290&partnerID=40&md5=5b8aea44190538d81cfe420c3db9d474
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/105350
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/105350
dc.identifier2-s2.0-59649108290
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1250170
dc.descriptionSchistosomiasis, an important disease in Brazil, is caused by a trematode of the genus Schistosoma, reaching millions of person in one of the most endemic region of this disease in the whole globe. The main goal of this work was to syntetize the 6-formyl- oxamniquine derivative and evaluate its biological activity. The 6-formyl-oxamniquine derivative was obtained by the oxidation of oxamniquine with MnO 2, applying CH 2Cl 2 as solvent at room temperature for 24 hours. The obtaintion of 6-formyl-oxamniquine derivative compound was confirmed by IR spectroscopy and 13C NMR and 1H NMR, presenting similar activity when compared to the commercial oxamniquine (Mansil®).
dc.description44
dc.description4
dc.description749
dc.description754
dc.descriptionALMEIDA, A.E., FERREIRA, A.G., CRESPI, M.S., ANDRADE, Z.A., CHUNG, M.C., Synthesis and thermal study of prodrug of oxamniquine (2006) J. Therm. Anal. Calorim, 83 (2), pp. 277-281
dc.descriptionAMARAL, R.S., PORTO, M.A.S., Evolução e situação do controle da esquistossomose no Brasil. (1994) Rev. Soc. Bras. Med. Trop, 27 (2), pp. 73-90
dc.descriptionBARBERATO-FILHO, S., ARGIONI, C., PINTO, C.P.L.S., CHIODELLI, S.G., VELLOSA, S.A.G., SILVA, R.M., SILVEIRA, M.A.B., Synthesis and evaluation of new oxamniquine derivatives (2002) Int. J. Pharm, 233 (1-2), pp. 35-41
dc.descriptionBUNDGAARD, H., Novel chemical approaches in prodrug design (1991) Drugs Fut, 16 (5), pp. 443-458
dc.descriptionBURGER, A., The conceptual background and development of medicinal chemistry (1995) Burger's Medicinal Chemistry and Drug Discovery: Principles and Practice, 1, pp. 1-8. , WOLFF, M. E, Ed, John Wiley & Sons: New York
dc.descriptionCARVALHO, E.M., ACIOLI, M.D., BRANCO, M.A.F., COSTA, A.M., CESSE, E.A.P., ANDRADE, A.G., MELLO, E.M.L.L., Evolução da esquistossomose na Zona da Mata Sul de Pernambuco. Epidemiologia e situação atual: Controle ou descontrole? (1998) Cad. Saúde Pública, 14 (4), pp. 787-795
dc.descriptionCDC. Health and Safety Topics, Atlanta, G.A.: U.S. Department of health and Human Services, CDC, 2007. Disponível em: 〈http://www.cdc.gov/ default.htm.〉. Acesso em: 20 de out. 2007CHUNG, M.C., FERREIRA, E.I., O processo de latenciação no planejamento de fármacos. (1999) Quim. Nova, 22 (1), pp. 75-84
dc.descriptionCIOLI, D., PICA-MATTOCCIA, L., ARCHER, S., Drug resistance in schistosomes (1993) Parasitol. Today, 9 (5), pp. 162-166
dc.descriptionEL-HAMOULY, W., PICA-MATTOCIA, L., CIOLI, D., SCHWARTZ, H.M., ARCHER, S., Studies on some derivatives of oxamniquine (1988) J. Med. Chem, 31 (8), pp. 1629-1631
dc.descriptionKATZ, N., PELLEGRINO, J., MEMORIA, J.M.P., Quantitative oogram method in Cebus monkeys experimentally infected with Schistosoma mansoni (1972) J. Parasitol, 52 (5), pp. 917-919
dc.descriptionMERCK index. 14.ed. Whitehouse Station, 2006. p.1192OLIVIER, L., STIREWALT, M.A., An efficient meted for exposure of mice to cercarie of Schistosoma mansoni (1952) J. Parasitol, 38, pp. 19-23
dc.description(1994) Technical Reports Series, O Controle da Esquistossomose, 830. , ORGANIZAÇÃO MUNDIAL DE SAÚDE, Segundo Relatório do Comitê de Especialistas da OMS. Rio de Janeiro: Editora Fiocruz. 110p
dc.descriptionPARISE-FILHO, R., ARAÚJO, A.A.S., SANTOS-FILHO, M., MATOS, J.R., SILVEIRA, M.A.B., BRANDT, C.A., Thermoanalytical characterization of potentially schistosomicide polymeric derivatives (2004) J. Therm. Anal. Calorim, 75 (2), pp. 487-494
dc.descriptionREY, L., Esquistossomíase Mansônica, I., Bases da Parasitologia Médica (2002) 3 aed, pp. 413-443. , Rio de Janeiro: Guanabara Koogan
dc.descriptionSHEKHAR, K.C., Schistosomiasis drug therapy and treatment consideration (1991) Drugs, 42 (3), pp. 379-405
dc.descriptionWORLD HEALTH ORGANIZATION. WHO, 2006. Schistosomiasis and intestinal parasites control. Planning and technical guidance. Communicable diseases prevention and control. Disponível em: 〈http://www.WHO.Ch./cds. 〉. Acesso em: 16 de out. 2006YOLLES, T.K., MOORE, P.V., DE GINSTI, D.L., RIPSON, C.A., MELENEY, H.E., A technique for the perfusion of laboratory animals for the recovery of schistosomes (1947) J. Parasitol, 33, pp. 419-426
dc.languagept
dc.publisher
dc.relationRevista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences
dc.rightsfechado
dc.sourceScopus
dc.titleSynthesis And Biological Activity Of 6-formyl-oxamniquine Derivative [síntese E Atividade Biológica Do Derivado 6-formil-oxamniquina]
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución