Artículos de revistas
Statistical Mixture Design-varimax Factor Optimization For Selective Compound Extraction From Plant Material
Registro en:
Analytica Chimica Acta. , v. 613, n. 1, p. 48 - 55, 2008.
32670
10.1016/j.aca.2008.02.051
2-s2.0-40949111787
Autor
Soares P.K.
Bruns R.E.
Scarminio I.S.
Institución
Resumen
Varimax-transformed chromatograms of compounds extracted from Erythrina speciosa Andrews leaves by simplex centroid design mixtures of dichloromethane, hexane, ethanol and acetone are reported and compared with principal component results. Six varimax factors were investigated focusing on the three main groups of extracted compounds with retention times of 1.7, 3.1 and 6.6 min. Varimax models provide chromatographic loading profiles that are simpler than their principal component counterparts. Furthermore varimax score models in terms of extraction medium compositions are simpler to interpret. The first varimax model results in an optimum extraction mixture of 71% dichloromethane-29% acetone although substitution of acetone by ethanol results in an almost identical extraction profile. The second varimax score model predicts optimum extraction binary mixtures with hexane proportions ranging from 50 to 100% for complementary proportions of either acetone or ethanol. The third varimax factor provides a response surface that is very similar to the one found for the third PC. Confirmatory experiments were performed to validate the model predictions. © 2008 Elsevier B.V. All rights reserved. 613 1 48 55 Defernez, M., Colquhoun, I.J., (2003) Phytochemistry, 62, p. 1009 Bowie, B.T., Chase, D.B., Griffiths, P.R., (2000) Appl. Spectrosc., 54, pp. 164A Chuang, C.-C., Wen, W.-C., Sheu, S.-J., (2007) J. Sep. Sci., 30, p. 1827 Gorsuch, R.L., (1983) Factor Analysis. 2nd ed., , Lawrence Erlbaum Associates, Hillsdale Jolliffe, I.T., (1986) Principal Component Analysis, , Springer, NY Andrew, J.J., Hancewicz, T.M., (1998) Appl. Spectrosc., 52, p. 797 Lavine, B.K., Davidson, C.E., Ritter, J., Westover, D.J., Hancewicz, T., (2004) Microchem. J., 76, p. 173 Andrade, S.R.C., Scarminio, I.S., Nery, M.M., Oliveira, A.C., (2003) J. Pharm. Biomed. Anal., 33, p. 655 Lavine, B.K., Ritter, J.P., Voigtman, E., (2002) Microchem. J., 72, p. 163 Schoonover, J.R., Marx, R., Nichols, W.R., (2004) Vibr. Spectrosc., 35, p. 239 Março, P.H., Scarminio, I.S., (2007) Anal. Chim. Acta, 583, p. 138 Soares, P.K., Bruns, R.E., Scarminio, I.S., (2007) J. Sep. Sci., 30, p. 3302 Cornell, J.A., (2002) Experiments with Mixtures. 3rd ed., , Wiley, NY Davies, T., (1998) Analusis Mag., 26, pp. M17 Sharif, M.A., Illman, D.L., Kowalski, B.R., (1986) Chemometrics, , Wiley, NY Mardia, K.V., Kent, J.T., Bibby, J.M., (1980) Multivariate Analysis. 3rd ed., , Academic Press Inc., NY Reyment, R., Jöreskog, K.G., (1993) Applied Factor Analysis in the Natural Sciences. 2nd ed., , Cambridge University Press Báez, A., Belmont, R., García, R., Padilla, H., Torres, M.C., (2007) Atmos. Res., 6, p. 61 Yu, T.-Y., Chang, L.-F.W., (2000) Atmos. Environ., 34, p. 4499 Cheng, M.D., Tanner, R.L., (2002) Atmos. Environ., 36, p. 5795 Kumru, M.N., Bakaç, M., (2003) J. Geochem. Explor., 77, p. 81 Senaratne, I., Shooter, D., (2004) Atmos. Environ., 38, p. 3049