Artículos de revistas
High Susceptibility Of Activated Lymphocytes To Oxidative Stress-induced Cell Death
Registro en:
Anais Da Academia Brasileira De Ciencias. , v. 80, n. 1, p. 137 - 148, 2008.
13765
2-s2.0-41149118401
Autor
Degasperi G.R.
Castilho R.F.
Vercesi A.E.
Institución
Resumen
The present study provides evidence that activated spleen lymphocytes from Walker 256 tumor bearing rats are more susceptible than controls to iert-butyl hydroperoxide (t-BOOH)-induced necrotic cell death in vitro. The iron chelator and antioxidant deferoxamine, the intracellular Ca2+ chelator BAPTA, the L-type Ca2+ channel antagonist nifedipine or the mitochondrial permeability transition inhibitor cyclosporin A, but not the calcineurin inhibitor FK-506, render control and activated lymphocytes equally resistant to the toxic effects of t-BOOH. Incubation of activated lymphocytes in the presence of t-BOOH resulted in a cyclosporin A-sensitive decrease in mitochondrial membrane potential. 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