The Effects Of Long-term Dopaminergic Treatment On Locomotor Behavior In Rats

dc.creatorde Almeida W.A.O.
dc.creatorEsteves A.M.
dc.creatorde Almeida C.L.
dc.creatorLee K.S.
dc.creatorFrank M.K.
dc.creatorMariano M.O.
dc.creatorFrussa-Filho R.
dc.creatorTufik S.
dc.creatorde Mello M.T.
dc.date2014
dc.date2015-06-25T17:55:33Z
dc.date2015-11-26T14:39:25Z
dc.date2015-06-25T17:55:33Z
dc.date2015-11-26T14:39:25Z
dc.date.accessioned2018-03-28T21:45:06Z
dc.date.available2018-03-28T21:45:06Z
dc.identifier
dc.identifierSleep Science. Flass, v. 7, n. 4, p. 203 - 208, 2014.
dc.identifier19840659
dc.identifier10.1016/j.slsci.2014.10.003
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84924277099&partnerID=40&md5=42142f37723ce62241682b90ecf16d97
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86862
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86862
dc.identifier2-s2.0-84924277099
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1249994
dc.descriptionLong-term treatments with dopaminergic agents are associated with adverse effects, including augmentation. Augmentation consists of an exacerbation of restless legs syndrome (a sleep-related movement disorder) symptoms during treatment compared to those experienced during the period before therapy was initiated. The objective of this study was to examine locomotor activity in rats after long-term dopaminergic treatment and its relationship with expression of the D2 receptor, in addition to demonstrating possible evidence of augmentation. The rats were divided into control (CTRL) and drug (Pramipexole—PPX) groups that received daily saline vehicle and PPX treatments, respectively, for 71 days. The locomotor behavior of the animals was evaluated weekly in the Open Field test for 71 days. The expression of the dopamine D2 receptor was evaluated by Western Blot analysis. The animals that received the PPX demonstrated a significant reduction in locomotor activity from day 1 to day 57 and a significant increase in immobility time from day 1 to day 64 relative to baseline values, but these values had returned to baseline levels at 71 days. No changes in the expression of the D2 receptor were demonstrated after treatment with a dopaminergic agonist. This study suggests changes in locomotor activity in rats after long-term PPX treatment that include an immediate reduction of locomotion and an increase in immobilization, and after 64 days, these values returned to baseline levels without evidence of augmentation. In addition, it was not possible to demonstrate a relationship between locomotor activity and the expression of D2 receptors under these conditions.
dc.description7
dc.description4
dc.description203
dc.description208
dc.description30850004; NSFC; National Natural Science Foundation of China
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dc.languageen
dc.publisherFLASS
dc.relationSleep Science
dc.rightsfechado
dc.sourceScopus
dc.titleThe Effects Of Long-term Dopaminergic Treatment On Locomotor Behavior In Rats
dc.typeArtículos de revistas


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