Clinicopathological And Immunohistochemical Evaluation Of Oral And Oropharyngeal Squamous Cell Carcinoma In Chilean Population

dc.creatorRivera C.
dc.creatorGonzalez-Arriagada W.A.
dc.creatorLoyola-Brambilla M.
dc.creatorde Almeida O.P.
dc.creatorColetta R.D.
dc.creatorVenegas B.
dc.date2014
dc.date2015-06-25T17:55:20Z
dc.date2015-11-26T14:37:49Z
dc.date2015-06-25T17:55:20Z
dc.date2015-11-26T14:37:49Z
dc.date.accessioned2018-03-28T21:42:21Z
dc.date.available2018-03-28T21:42:21Z
dc.identifier
dc.identifierInternational Journal Of Clinical And Experimental Pathology. E-century Publishing Corporation, v. 7, n. 9, p. 5968 - 5977, 2014.
dc.identifier19362625
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84911464358&partnerID=40&md5=8cec2395578557364993f76e46900719
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86806
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86806
dc.identifier2-s2.0-84911464358
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1249283
dc.descriptionIn oral and oropharyngeal squamous cell carcinoma (OCSCC and OPSCC) exist an association between clinical and histopathological parameters with cell proliferation, basal lamina, connective tissue degradation and surrounding stroma markers. We evaluated these associations in Chilean patients. A convenience sample of 37 cases of OCSCC (n=16) and OPSCC (n=21) was analyzed clinically (TNM, clinical stage) and histologically (WHO grade of differentiation, pattern of tumor invasion). We assessed the expression of p53, Ki67, HOXA1, HOXB7, type IV collagen (ColIV) and carcinoma-associated fibroblast (a-SMA-positive cells). Additionally we conducted a univariate/bivariate analysis to assess the relationship of these variables with survival rates. Males were mostly affected (56.2% OCSCC, 76.2% OPSCC). Patients were mainly diagnosed at III/IV clinical stages (68.8% OCSCC, 90.5% OPSCC) with a predominantly infiltrative pattern invasion (62.9% OCSCC, 57.1% OPSCC). Significant association between regional lymph nodes (N) and clinical stage with OCSCC-HOXB7 expression (Chi-Square test P < 0.05) was observed. In OPSCC a statistically significant association exists between p53, Ki67 with gender (Chi-Square test P < 0.05). In OCSCC and OPSCC was statistically significant association between ki67 with HOXA1, HOXB7, and between these last two antigens (Pearson's Correlation test P < 0.05). Furthermore OPSCC-p53 showed significant correlation when it was compared with a-SMA (Kendall's Tau-c test P < 0.05). Only OCSCC-pattern invasion and OPSCC-primary tumor (T) pattern resulted associated with survival at the end of the follow up period (Chi-Square Likelihood Ratio, P < 0.05). Clinical, histological and immunohistochemical features are similar to seen in other countries. Cancer proliferation markers were associated strongly from each other. Our sample highlights prognostic value of T and pattern of invasion, but the conclusions may be limited and should be considered with caution (small sample). Many cases were diagnosed in the advanced stages of the disease, which suggests that the diagnosis of OCSCC and OPSCC is made late.
dc.description7
dc.description9
dc.description5968
dc.description5977
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dc.languageen
dc.publisherE-Century Publishing Corporation
dc.relationInternational Journal of Clinical and Experimental Pathology
dc.rightsaberto
dc.sourceScopus
dc.titleClinicopathological And Immunohistochemical Evaluation Of Oral And Oropharyngeal Squamous Cell Carcinoma In Chilean Population
dc.typeArtículos de revistas


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