S-nitrosoglutathione Accelerates Recovery From 5-fluorouracil-induced Oral Mucositis

dc.creatorSkeff M.A.
dc.creatorBrito G.A.C.
dc.creatorDe Oliveira M.G.
dc.creatorBraga C.M.
dc.creatorCavalcante M.M.
dc.creatorBaldim V.
dc.creatorHolanda-Afonso R.C.
dc.creatorSilva-Boghossian C.M.
dc.creatorColombo A.P.
dc.creatorRibeiro R.A.
dc.creatorMoura-Neto V.
dc.creatorLeitao R.F.C.
dc.date2014
dc.date2015-06-25T17:55:15Z
dc.date2015-11-26T14:37:21Z
dc.date2015-06-25T17:55:15Z
dc.date2015-11-26T14:37:21Z
dc.date.accessioned2018-03-28T21:41:45Z
dc.date.available2018-03-28T21:41:45Z
dc.identifier
dc.identifierPlos One. Public Library Of Science, v. 9, n. 12, p. - , 2014.
dc.identifier19326203
dc.identifier10.1371/journal.pone.0113378
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84916912058&partnerID=40&md5=599457606c2417b9ba90a2f7660acb5b
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86788
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86788
dc.identifier2-s2.0-84916912058
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1249128
dc.descriptionIntroduction: Mucositis induced by anti-neoplastic drugs is an important, doselimiting and costly side-effect of cancer therapy. Copyright:Aim: To evaluate the effect of the topical application of S-nitrosoglutathione (GSNO), a nitric oxide donor, on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters.Materials and Methods: Oral mucositis was induced in male hamsters by two intraperitoneal administrations of 5-FU on the first and second days of the experiment (60 and 40 mg/kg, respectively) followed by mechanical trauma on the fourth day. Animals received saline, HPMC or HPMC/GSNO (0.1, 0.5 or 2.0 mM) 1 h prior to the 5-FU injection and twice a day for 10 or 14 days. Samples of cheek pouches were harvested for: histopathological analysis, TNF-α and IL-1β levels, immunohistochemical staining for iNOS, TNF-α, IL-1β, Ki67 and TGF-β RII and a TUNEL assay. The presence and levels of 39 bacterial taxa were analyzed using the Checkerboard DNA-DNA hybridization method. The profiles of NO released from the HPMC/GSNO formulations were characterized using chemiluminescence.Results: The HPMC/GSNO formulations were found to provide sustained release of NO for more than 4 h at concentration-dependent rates of 14 to 80 nmol/mL/h. Treatment with HPMC/GSNO (0.5 mM) significantly reduced mucosal damage, inflammatory alterations and cell death associated with 5-FU-induced oral mucositis on day 14 but not on day 10. HPMC/GSNO administration also reversed the inhibitory effect of 5-FU on cell proliferation on day 14. In addition, we observed that the chemotherapy significantly increased the levels and/or prevalence of several bacterial species.Conclusion: Topical HPMC/GSNO accelerates mucosal recovery, reduces inflammatory parameters, speeds up re-epithelization and decreases levels of periodontopathic species in mucosal ulcers.
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dc.languageen
dc.publisherPublic Library of Science
dc.relationPLoS ONE
dc.rightsaberto
dc.sourceScopus
dc.titleS-nitrosoglutathione Accelerates Recovery From 5-fluorouracil-induced Oral Mucositis
dc.typeArtículos de revistas


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