The Clinical Impact Of Cerebellar Grey Matter Pathology In Multiple Sclerosis

dc.creatorDamasceno A.
dc.creatorDamasceno B.P.
dc.creatorCendes F.
dc.date2014
dc.date2015-06-25T17:54:52Z
dc.date2015-11-26T14:36:49Z
dc.date2015-06-25T17:54:52Z
dc.date2015-11-26T14:36:49Z
dc.date.accessioned2018-03-28T21:40:53Z
dc.date.available2018-03-28T21:40:53Z
dc.identifier
dc.identifierPlos One. Public Library Of Science, v. 9, n. 5, p. - , 2014.
dc.identifier19326203
dc.identifier10.1371/journal.pone.0096193
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84900407788&partnerID=40&md5=d4582eeda6ce1e5d96a233803380ac78
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86757
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86757
dc.identifier2-s2.0-84900407788
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1248906
dc.descriptionBackground: The cerebellum is an important site for cortical demyelination in multiple sclerosis, but the functional significance of this finding is not fully understood. Objective: To evaluate the clinical and cognitive impact of cerebellar grey-matter pathology in multiple sclerosis patients. Methods: Forty-two relapsing-remitting multiple sclerosis patients and 30 controls underwent clinical assessment including the Multiple Sclerosis Functional Composite, Expanded Disability Status Scale (EDSS) and cerebellar functional system (FS) score, and cognitive evaluation, including the Paced Auditory Serial Addition Test (PASAT) and the Symbol-Digit Modalities Test (SDMT). Magnetic resonance imaging was performed with a 3T scanner and variables of interest were: brain white-matter and cortical lesion load, cerebellar intracortical and leukocortical lesion volumes, and brain cortical and cerebellar white-matter and grey-matter volumes. Results: After multivariate analysis high burden of cerebellar intracortical lesions was the only predictor for the EDSS (p<0.001), cerebellar FS (p = 0.002), arm function (p = 0.049), and for leg function (p<0.001). Patients with high burden of cerebellar leukocortical lesions had lower PASAT scores (p = 0.013), while patients with greater volumes of cerebellar intracortical lesions had worse SDMT scores (p = 0.015). Conclusions: Cerebellar grey-matter pathology is widely present and contributes to clinical dysfunction in relapsing-remitting multiple sclerosis patients, independently of brain grey-matter damage. © 2014 Damasceno et al.
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dc.languageen
dc.publisherPublic Library of Science
dc.relationPLoS ONE
dc.rightsaberto
dc.sourceScopus
dc.titleThe Clinical Impact Of Cerebellar Grey Matter Pathology In Multiple Sclerosis
dc.typeArtículos de revistas


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