Repeated Swimming Stress And Responsiveness Of The Isolated Rat Pacemaker To The Chronotropic Effect Of Noradrenaline And Isoprenaline: Role Of Adrenal Corticosteroids

dc.creatorSpadari R.C.
dc.creatorDe Moraes S.
dc.date1988
dc.date2015-06-30T13:40:01Z
dc.date2015-11-26T14:36:30Z
dc.date2015-06-30T13:40:01Z
dc.date2015-11-26T14:36:30Z
dc.date.accessioned2018-03-28T21:40:22Z
dc.date.available2018-03-28T21:40:22Z
dc.identifier
dc.identifierGeneral Pharmacology. , v. 19, n. 4, p. 553 - 557, 1988.
dc.identifier3063623
dc.identifier10.1016/0306-3623(88)90163-2
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0023884858&partnerID=40&md5=87e8fcf6e14e5ffa950c5bc6c94e702d
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/98093
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/98093
dc.identifier2-s2.0-0023884858
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1248775
dc.description1. 1. Repeated swimming stress (three daily sessions) resulted in an increased plasma corticosterone level and subsensitivity of the isolated rat pacemaker to noradrenaline and isoprenaline. 2. 2. Repeated swimming stress was found to decrease the affinity of β1-adrenoreceptors for metoprolol. 3. 3. Bilateral adrenalectomy performed 2 days before repeated swimming stress abolished the development of pacemaker subsensitivity to noradrenaline and isoprenaline and the decrease in β1-adrenoreceptors affinity for metoprolol. 4. 4. It is concluded that adrenal corticosteroids, at least partially, mediate the swimming stress-induced subsensitivity of the isolated rat pacemaker to noradrenaline and isoprenaline. © 1988.
dc.description19
dc.description4
dc.description553
dc.description557
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dc.languageen
dc.publisher
dc.relationGeneral Pharmacology
dc.rightsfechado
dc.sourceScopus
dc.titleRepeated Swimming Stress And Responsiveness Of The Isolated Rat Pacemaker To The Chronotropic Effect Of Noradrenaline And Isoprenaline: Role Of Adrenal Corticosteroids
dc.typeArtículos de revistas


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