Gastroprotective Effects (in Rodents) Of A Flavonoid Rich Fraction Obtained From Syngonanthus Macrolepsis

dc.creatorBatista L.M.
dc.creatorDe Almeida A.B.A.
dc.creatorDe Morais Lima G.R.
dc.creatorDe Sousa Falcao H.
dc.creatorDe Pietro Magri L.
dc.creatorLuiz-Ferreira A.
dc.creatorDos Santos L.C.
dc.creatorHiruma-Lima C.A.
dc.creatorVilegas W.
dc.creatorSouza Brito A.R.M.
dc.date2014
dc.date2015-06-25T17:54:49Z
dc.date2015-11-26T14:36:27Z
dc.date2015-06-25T17:54:49Z
dc.date2015-11-26T14:36:27Z
dc.date.accessioned2018-03-28T21:40:16Z
dc.date.available2018-03-28T21:40:16Z
dc.identifier
dc.identifierJournal Of Pharmacy And Pharmacology. , v. 66, n. 3, p. 445 - 452, 2014.
dc.identifier223573
dc.identifier10.1111/jphp.12175
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84894289099&partnerID=40&md5=139cf11073a3b70b9b9e1d8bf0726ce8
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86752
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86752
dc.identifier2-s2.0-84894289099
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1248750
dc.descriptionObjectives Syngonanthus macrolepis, popularly known in Brazil as 'sempre-vivas', is a plant from the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. The species contains a variety of constituents, including flavonoids with gastroprotective effect. In this work, a flavonoid-rich fraction (Sm-FRF) obtained from scapes of S. macrolepis was investigated for preventing gastric ulceration in mice and rats. Methods The activity was evaluated in models of induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs and pylorus ligation). The cytoprotective mechanisms of the Sm-FRF in relation to sulfhydryl (SH) groups, nitric oxide (NO) and antioxidant enzymes were also evaluated. Key findings The Sm-FRF (100 mg/kg, p.o.) significantly reduced gastric injury in all models, and did not alter gastric juice parameters after pylorus ligation. Conclusions The results indicate significant gastroprotective activity for the Sm-FRF, which probably involves the participation of both SH groups and the antioxidant system. Both are integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors. © 2013 Royal Pharmaceutical Society.
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dc.languageen
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dc.relationJournal of Pharmacy and Pharmacology
dc.rightsfechado
dc.sourceScopus
dc.titleGastroprotective Effects (in Rodents) Of A Flavonoid Rich Fraction Obtained From Syngonanthus Macrolepsis
dc.typeArtículos de revistas


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