[No abstract available]473151159Lipski, P.E., Rheumatoid arthitis (1998) Harrison's Principles of Internal Medicine, , Kasper DL, Braunwald. E, Fauci AS, et al, International edition, 14th ed, New York: McGraw HillGuidelines for the management of rheumatoid arthritis (2002) Arthitis Rheum, 46, pp. 328-346. , American College of Rheumatology Subcommittee on Rheumatoid Arthritis GuidelinesArnett, F.C., Edworthy, S.M., Bloch, D.A., The American Rheumatism Association 1987 revised criteria for classification of rheumatoid arthritis (1988) Arthritis Rheum, 31, pp. 315-324Emery P, Breedveld FC, Dougados M, Kalden Jr, Schiff MH, Smolen JS: Early referral recommendation for newly diagnosed rheumatoid arthritis: evidence based development of a clinical guide. Ann Rheum Dis 61:290, 2002Van der Heijde DM: Joint erosions and patients with early rheumatoid arthritis. Br J Rheumatol 34(suppl)2:74-8, 1995Dixey, J., Solymossy, C., Young, A., Early RA Study: Is it possible to predict radiological damage in early rheumatoid arthritis (RA)? A report on the occurrence, progression and prognostic factors of radiological erosions over the first 3 years in 866 patients from the Early RA Study (ERAS) (2004) J Rheumatol, 69 (SUPPL.), pp. 48-54Venrooij, V., van de, Putte, L.B., Is assaying autoantibodies useful for diagnosing early rheumatoid arthritis? Nat Clin Pract (2005) Rheumatol, 1, pp. 4-5Avouac, J., Gossec, L., Dougados, M., Diagnostic and predictive value of anti-ciclyc citrulinate antibodies in rheumatoid arthritis: A systematic literature review (2006) Ann Rheum Dis, 65, pp. 845-851van der Heijde, D.M., van't Hof, M.A., van Riel, P.L., Judging disease activity in clinical practice in rheumtoid arthritis: First step in the development of a disease activity score (1990) Ann Rheum Dis, 49, pp. 916-920Prevoo, M.L., van't Hof, M.A., Kuper, H.H., Modified disease activity scores that include twenty eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis (1995) Arthritis Rheum, 38, pp. 44-48Smolen, J.S., Breedveld, F.C., Schiff, M.H., A simplified disease activity index for rheumatoid arthritis for use in clinical practice (2003) Rheumatology (Oxford), 42, pp. 244-257Aletaha, D., Nell, V.P., Stamm, T., Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: Validation of a clinical activity score (2005) Arthritis Res Ther, 7, pp. R-796-R-806Aletaha, D., Pooled indices to measure rheumatoid arthritis activity: A good reflection of the physician's mind? (2006) Arthritis Res Ther, 8, p. 102Aletaha, D., Smolen, J., The simplified disease activity index (SDAI) and the clinical disease activity index (CDAI): A review of their usefulness and validity in rheumatoid arthritis (2005) Clin Exp Rheumatol, 23 (SUPPL. 39), pp. SI00-SI08Albers, J.M.C., Paimela, L., Kurki, P., Treatment strategy, disease activity, and outcome in four cohorts of patients with early rheumatoid artrhitis (2001) Ann Rehm Dis, 60, pp. 453-458Gotzsche PC, Johansen HK: Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis. Cochrane Database Syst Rwv 2:CD000189, 2000Moreland, L.W., O'Dell, J.R., Glucocorticoids and rheumatoid arthritis: Back to the future? (2002) Arthritis Rheum, 46, pp. 2553-2563Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis: 2001 update (2001) Arthritis Rheum, 44, pp. 1496-1503. , American College of Rheumatology Ad Hoc Committee on Glucocorticoid-Induced OsteoporosisHelin-Salmivaara, A., Virtanen, A., Vesalamen, R., NSAID use and the risk of hospitalization for first myocardial infarction in the general population: A nationwide case-control study from Finland (2006) Eur Heart J, 27 (14), pp. 1657-1663Suissa S, Bernatsky S, Hudson M: Antirheumatic drug use and the risk of acute myocardial infarction. Arthritis Rheum 55(4):53 1-6, 2006Suarez-Almazor, M.E., Belseck, E., Shea, B., Antimalarials for treating rheumatoid arthritis (2000) Cochrane Database Syst Rev, 4. , CD000959van den Borne, B.E., Landewe, R.B., Rietveld, J.H., Choroquine therapy in patients with recent-onset rheumatoid arthritis: The clinical response can be predicted by the low level of acte-phase reaction at baseline (1999) Clin Rheum, 18, pp. 309-372Suarez-Almazor, M.E., Belseck, E., Shea, B., Wells, G., Tugwell, P., Sulfasalazine for rheumatoid arthritis (2000) Cochrane Database Syst Rev, 2. , CD000958Sharp, J.T., Strand, V., Leung, H., Hurley, F., Loew-Frierich (Leflunomide rheumatoid arthritis investigators group): Treatment with leflunomide slows radiographic progression of rheumatoid Arthritis. Results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis. Leflunomide Rheumatoid Arthritis Investigators Group (2000) Arthritis Rheum, 43, pp. 495-505Suarez-Almazor, M.E., Belseck, E., Shea, B., Wells, G., Tugwell, P., Methotrexate for rheumatoid arthritis (2000) Cochrane Database Syst Rev, 2. , CD000957Choen, S., Cannon, G.W., Schiff, M., (1984) Two-Year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate, 44. , Utilization of Leflunomide in the treatment of Rheumatoid Arthritis Trial Investigator Group. Arthritis Rheum, 92Suarez-Almazor, M.E., Spooner, C., Belseck, E., Azathioprine for rheumatoid arthritis (2000) Cochrane Database Syst Rev, 4. , CD001461Wells, G., Haguenauer, D., Shea, B., Suarez-Almazor, M.E., Welch, V.A., Tugwell, R., Cyclosporin for Rheumatoid Arthritis (2000) Cochrane Database Syst Rev, 2. , CD001083Stein, C.M., Pincus, T., Yocum, D., Combination treatment of severe rheumatoid arthritis with cyclosporine and methotrexate for forty-eight weeks: An open-label extension study. The Methotrexate-Cyclosporine Combination Study Group (1997) Arthritis Rheum, 40, pp. 1843-1851O'Dell, J.R., Leff, R., Paulsen, G., (RAIN): Treatment of rheumatoid artritis with methotrexate and hydroxycloroquine, methotrexate and sulfasalazine, or a combination of the three medications. Results of a two-year, randomized, double blind, placebo-controlled trial (2002) Arthritis Rheum, 46, pp. 1164-1170Weinblatt, M.E., Kremer, J.M., Coblyn, J.S., Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis (1999) Arthritis Rheum, 42, pp. 1322-1328Criscione, L.G., St. Clair, E.W., Tumor necrosis factor - alfa antagonists for the treatment of rheumatic diseases (2002) Current Op Rheumatol, 14, pp. 204-211Furst DE, Breedveld FC, Burmester GER, et al.: Update consensus statement on tumor necrosis factor blocking agents for the treatment of rheumatoid arthritis (May 2000). Ann Rheum Dis 59(suppl.I):il-2, 2000Weinblatt, M.E., Keystone, E.C., Furst, D.E., Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial (2003) Arthritis Rheum, 48, pp. 35-45Furst, D.E., Schiff, M.H., fleischmann, R.M., Adalimumab, a fully human anti tumor necrosis factor-alpha monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: Results of STAR (Safety Trial of Adalimumab in Rheumatoid arthritis) (2003) J Rheumatol, 30, pp. 2563-2571Moreland, L.W., Schiff, M.H., Baumgartener, S.W., Etanercept therapy in Rheumatoid Arthritis: A randomized, controlled trial (1999) Ann Intern Med, 130, pp. 478-486Weinblatt, M.E., Kremer, J.M., Bankhurst, A.D., A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate (1999) N Engl J Med, 340, pp. 253-259Maini, R.N., Breedveld, F.C., Kalden, J.R., Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor aloha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis (1998) Arthritis Rheum, 41, pp. 1552-1563Lipsky, P.E., van der Heijde, D.M., St Clair, E.W., Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group (2000) N Engl J Med, 343, pp. 1594-1602Perdriger, A., Mariette, X., Kuntz, Safety of infliximab used in combination with leflunomide or azathioprine in daily clinical practice (2006) J Rheumatol, 33, p. 865Mangini C, Melo FAF. Artrite reumatóide, terapia imunossupressora e tuberculose. Ver Bras Reumatol 43:XI(editorial), 2003Hochberg MC, Tracy JK, Hawkins-Holt M, Flores RH: Comparison of the efficacy of the tumour necrosis factor alpha blocking agents adalimumab, etanercept, and infliximab when added to methotrexate in patients with active rheumatoid arthritis. Ann Rheum Dis 62(suppl2):ii13-6, 2003Cohen, S.B., Emery, P., Greenwald, M.W., Reflex Trial Group. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy. Results of a multicenter, randomized, double-blind, placebo-contoled, phase III trial evaluating primary efficacy and safety at twenty four weeks (2006) Arthritis Rheum, 54, pp. 2793-2806Popa, C., Leandro, M.J., Cambridge, G., Edwards, J.C., Repeated B lymphocyte depletion with rituximab in rheumatoid arthritis over 7 yrs (2006) Rheumatology, , Oxford, Epub ahead of printvan Vollenhoven, R., Emery, P., Bingham, C., Safety of rituximab in rheumatoid arthritis: Results of a pooled analysis (2006) Ann Rheum Dis, 65, p. 332Genovese, M.C., Becker, J.C., Schiff, M., Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition (2005) N Engl J Med, 353, pp. 1114-1123van Vollenhoven, R., Harju, A., Brannernark, S., Klareskog, L., Treatment with infliximab (Remicade) when etanercept (Embrel) has failed or vice versa: Data from the STURE registry showing that switching tumour necrosis factor alpha blockers can make sense (2003) Ann Rheum Dis, 62, pp. 1195-1198Wick, M.C., Lindblad, S., Klareskog, L., Van Vollenhoven, R.F., Adalimumab restores clinical response in patients who have lost response to infliximab (Remicade) or Etanercept (Embrel): Data from the STURE registry (2004) Ann Rheum Dis 63(suppll), 260