Cross-sectional Study Comparing Different Therapeutic Modalities For Cystic Lymphangiomas In Children

dc.creatorOlimpio H.O.
dc.creatorBustorff-Silva J.
dc.creatorde Oliveira Filho A.G.
dc.creatorde Araujo K.C.
dc.date2014
dc.date2015-06-25T17:54:28Z
dc.date2015-11-26T14:33:58Z
dc.date2015-06-25T17:54:28Z
dc.date2015-11-26T14:33:58Z
dc.date.accessioned2018-03-28T21:37:21Z
dc.date.available2018-03-28T21:37:21Z
dc.identifier
dc.identifierClinics. Universidade De Sao Paulo, v. 69, n. 8, p. 505 - 508, 2014.
dc.identifier18075932
dc.identifier10.6061/clinics/2014(08)01
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84906248422&partnerID=40&md5=37c2adb50dd6c83b6a03b27be8c3a65c
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86689
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86689
dc.identifier2-s2.0-84906248422
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1247983
dc.descriptionOBJECTIVE: Here, we describe our experience with different therapeutic modalities used to treat cystic lymphangiomas in children in our hospital, including single therapy with OK-432, bleomycin and surgery, and a combination of the three modalities. METHODS: We performed a retrospective, cross-sectional study including patients treated from 1998 to 2011. The effects on macrocystic lymphangiomas and adverse reactions were evaluated. Twenty-nine children with cystic lymphangiomas without any previous treatment were included. Under general anesthesia, patients given sclerosing agents underwent puncture of the lesion (guided by ultrasound when necessary) and complete aspiration of the intralesional liquid. The patients were evaluated with ultrasound and clinical examinations for a maximum follow-up time of 4 years. RESULTS: The proportions of patients considered cured after the first therapeutic approach were 44% in the surgery group, 29% in the bleomycin group and 31% in the OK-432 group. These proportions were not significantly different. Sequential treatment increased the rates of curative results to 71%, 74% and 44%, respectively, after the final treatment, which in our case was approximately 1.5 applications per patient. CONCLUSION: The results of this study indicate that most patients with cystic lymphangiomas do not show complete resolution after the initial therapy, regardless of whether the therapy is surgical or involves the use of sclerosing agents. To achieve complete resolution of the lesions, either multiple operations or a combination of surgery and sclerotherapy must be used and should be tailored to the characteristics of each patient. © 2014 CLINICS.
dc.description69
dc.description8
dc.description505
dc.description508
dc.descriptionGreinwald Jr., J.H., Burke, D.K., Sato, Y., Pous, R.I., Kimura, K., Bauman, N.M., Treatment of lymphangiomas in children: An update of Picibanil (OK-432) sclerotherapy (1999) Arch Otolaryngol Head Neck Surg., 121 (4), pp. 381-387
dc.descriptionMulliken, J.B., Glowacki, J., Hemangiomas and vascular malformations in infants and children: A classification based on endothelial characteristics (1982) Plast Reconstr Surg., 69 (3), pp. 412-422
dc.descriptionde Serres, L.M., Sie, K.C., Richardson, M.A., Lymphatic malformations of the head and neck. A proposal for staging (1995) Arch Otolaryngol Head Neck Surg., 121 (5), pp. 577-582. , http://dx.doi.org/10.1001/archotol.1995.01890050065012
dc.descriptionRautio, R., Keski-Nisula, L., Laranne, J., Laasonen, E., Treatment of lymphangiomas with OK-432 (Pincibanil) (2003) Cardiovasc Intervent Radiol., 26 (1), pp. 31-36
dc.descriptionGiguère, C.M., Bauman, N.M., Sato, Y., Burke, D.K., Greinwald, J.H., Pransky, S., Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: A prospective multi-institutional trial (2002) Arch Otolaryngol Head Neck Surg., 128 (10), pp. 1137-1144. , http://dx.doi.org/10.1001/archotol.128.10.1137
dc.descriptionLee, B.B., Laredo, J., Lee, T.S., Huh, S., Neville, R., Terminology and classification of congenital vascular malformations (2007) Phlebology, 22 (6), pp. 249-252. , http://dx.doi.org/10.1258/026835507782655236
dc.descriptionMulliken, J.B., Cutaneous vascular anomalies (1993) Semin Vasc Surg., 6 (4), pp. 204-218
dc.descriptionKasten, P., Schnöink, G., Bergmann, A., Papoutsi, M., Buttler, K., Rössler, J., Similarities and differences of human and experimental mouse lymphangiomas (2007) Dev Dyn., 236 (10), pp. 2952-2961. , http://dx.doi.org/10.1002/dvdy.21298
dc.descriptionKarpanen, T., Alltalo, K., Molecular biology and pathology of lymphangiogenesis (2008) Annu Rev of Pathol., 3, pp. 367-397. , http://dx.doi.org/10.1146/annurev.pathmechdis.3.121806.151515
dc.descriptionJi, R.C., Eshita, Y., Xing, L., Miura, M., Multiple expressions of lymphatic markers and morphological evolution of newly formed lymphatics in lymphangioma and lymph node lymphangiogenesis (2010) Microvasc Res., 80 (2), pp. 195-201. , http://dx.doi.org/10.1016/j.mvr.2010.04.002
dc.descriptionAlqahtani, A., Nguyen, L.T., Flageole, H., Shaw, K., Laberge, J.M., 25 years' experience with lymphangiomas in children (1999) J Pediatr Surg., 34 (7), pp. 1164-1168. , http://dx.doi.org/10.1016/S0022-3468(99)90590-0
dc.descriptionGiguère, C.M., Bauman, N.M., Smith, R.J., New treatment options for lymphangioma in infants and children (2002) Ann Otol Rhinol Laryngol., 111 (12 PART 1), pp. 1066-1075
dc.descriptionRuiz Jr., E., Valera, E.T., Veríssimo, F., Tone, L.G., OK-432 therapy for lymphangioma in children (2004) J Pediatr (Rio J)., 80 (2), pp. 154-158
dc.descriptionKim, K.H., Sung, M.W., Roh, J.L., Han, M.H., Sclerotherapy for congenital lesions in the head and neck (2004) Otolaryngol Head Neck Surg., 131 (3), pp. 307-316
dc.descriptionMathur, N.N., Rana, I., Bothra, R., Dhawan, R., Kathuria, G., Pradhan, T., Bleomycin sclerotherapy in congenital lymphatic and vascular malformations of head and neck (2005) Int J Pediatr Otorhinolaryngol, 69 (1), pp. 75-80. , http://dx.doi.org/10.1016/j.ijporl.2004.08.008
dc.descriptionOrford, J., Barker, A., Thonell, S., King, P., Murphy, J., Bleomycin therapy for cystic hygroma (1995) J Pediatr Surg., 30 (9), pp. 1282-1287. , http://dx.doi.org/10.1016/0022-3468(95)90485-9
dc.descriptionOgita, S., Tsuto, T., Nakamura, K., Deguchi, E., Iwai, N., OK-432 therapy in 64 patients with lymphangioma (1994) J Pediatr Surg., 29 (6), pp. 784-785. , http://dx.doi.org/10.1016/0022-3468(94)90370-0
dc.descriptionLee, B.B., Kim, Y.W., Seo, J.M., Hwang, J.H., Do, Y.S., Kim, D.I., Current concepts in lymphatic malformation (2005) Vasc Endovascular Surg., 39 (1), pp. 67-81. , http://dx.doi.org/10.1177/153857440503900107
dc.descriptionAcevedo, J.L., Shah, R.K., Brietzke, S.E., Nonsurgical therapies for lynphangiomas: A systematic review (2008) Otolaryngol Head Neck Surg., 138, pp. 418-424
dc.descriptionUmezawa, H., Recent advances in antitumor antibiotics (1978) Antibiot Chemother., 23, pp. 76-87
dc.descriptionYura, J., Hashimoto, T., Tsuruga, N., Shibata, K., Bleomycin treatment for cystic hygroma in children (1977) Nihon Geka Hokan., 46 (5), pp. 607-614
dc.descriptionTanigawa, N., Shimomatsuya, T., Takahashi, L., Inomata, Y., Tanaka, K., Satomura, K., Treatment of cystic hygroma and lymphangioma with the use of bleomycin fat emulsion (1987) Cancer., 60 (4), pp. 741-749. , http://dx.doi.org/10.1002/1097-0142(19870815)60:4,741::AID-CNCR2820600406.3.0.CO;2-2
dc.descriptionSiegel, R.D., Schiffman, F.J., Systemic toxicity following intracavitary administration of bleomycin (1990) Chest., 98 (2), p. 507. , http://dx.doi.org/10.1378/chest.98.2.507
dc.descriptionde Azambuja, E., Fleck, J.F., Barreto, S.S., Cunha, R.D., Pulmonary epithelial permeability in patients treated with bleomycin containing chemotherapy detected by technetium-99m diethylene triamine penta-acetic acid aerosol (99mTc-DTPA) scintigraphy (2005) Ann Nucl Med., 19 (2), pp. 131-135. , http://dx.doi.org/10.1007/BF03027392
dc.descriptionOgita, S., Tsuto, T., Tokiwa, K., Takashi, T., Intracystic injection of OK-432: A new sclerosing therapy for cystic hygroma in children (1987) Br J Surg., 74 (8), pp. 690-691
dc.description(2009), http://ftp.saude.sp.gov.br/ftpsessp/bibliote/informe_eletronico/2009/iels.fev.09/iels26/U_RS-ANVISA-RE-349_060209.pdf, Brazilian Nacional Agency of Sanitary Control (ANVISA), februery 6, Resolution number 349
dc.languageen
dc.publisherUniversidade de Sao Paulo
dc.relationClinics
dc.rightsaberto
dc.sourceScopus
dc.titleCross-sectional Study Comparing Different Therapeutic Modalities For Cystic Lymphangiomas In Children
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución