Cisplatin-induced Cytogenetic Alterations In V79 Cells

dc.creatorGoncalves E.M.
dc.creatorDos Santos M.T.
dc.creatorBertoncelli M.D.F.
dc.creatorBussamara G.A.
dc.creatorFuzzari T.
dc.creatorLima V.A.
dc.creatorPesotte L.C.
dc.creatorPitori V.
dc.creatorGenari S.C.
dc.date2007
dc.date2015-06-30T18:46:16Z
dc.date2015-11-26T14:33:56Z
dc.date2015-06-30T18:46:16Z
dc.date2015-11-26T14:33:56Z
dc.date.accessioned2018-03-28T21:37:19Z
dc.date.available2018-03-28T21:37:19Z
dc.identifier
dc.identifierCytologia. , v. 72, n. 2, p. 155 - 160, 2007.
dc.identifier114545
dc.identifier10.1508/cytologia.72.155
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-34548297906&partnerID=40&md5=7e67bc2e46750ef6ffc3dc6813b5a368
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/104692
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/104692
dc.identifier2-s2.0-34548297906
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1247977
dc.descriptionCisplatin is an antineoplastic agent used to treat solid malignancies, such as ovarian, testicular and bladder tumors. Studies have been shown that cisplatin induces genotoxic effects and chromosomal alterations that can result in genetic and chromosomal instability. In this work, we investigated the effects of cisplatin on the cytogenetic traits of cultured V79 cells based on the modal chromosome number, mitotic index, frequency of polyploidy and number of aneuploid metaphases. Cisplatin-treated V79 cells showed an altered chromosome number distribution, as well as an enhanced mitotic index, frequency of polyploidy and number of aneuploid metaphases. These alterations were probably related to the genetic instability produced by cisplatin. In addition, these cells showed characteristics associated with neoplastic development that corresponded to neoplastic processes related to the use of cisplatin in chemotherapy. © 2007 The Japan Mendel Society.
dc.description72
dc.description2
dc.description155
dc.description160
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dc.languageen
dc.publisher
dc.relationCytologia
dc.rightsaberto
dc.sourceScopus
dc.titleCisplatin-induced Cytogenetic Alterations In V79 Cells
dc.typeArtículos de revistas


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