Artículos de revistas
Crystallinity Of Dynasan ®114 And Dynasan ®118 Matrices For The Production Of Stable Miglyol ®-loaded Nanoparticles
Registro en:
Journal Of Thermal Analysis And Calorimetry. , v. 108, n. 1, p. 101 - 108, 2012.
13886150
10.1007/s10973-011-1613-7
2-s2.0-84858070958
Autor
Severino P.
Pinho S.C.
Souto E.B.
Santana M.H.A.
Institución
Resumen
This study focuses on the physicochemical characterization of lipid materials useful for the production of the so-called solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). The chosen lipids were Dynasan ®114 (glyceril trimyristate) and Dynasan ®118 (glyceril tristearate) as solid lipids (SL), melting temperature above 80 °C, and Miglyol ®812 (caprylic/capric triglyceride) and Miglyol ®840 (propylene glycol dicaprylate/dicaprate) as liquid lipids (LL), crystallizing below -15 °C. Raw lipids (pure or SL:LL mixtures) were analyzed by differential scanning calorimetry (DSC), wide angle X-ray diffraction (WAXD), and Polarized Light Microscopy (PLM), before and after tempering at 80 °C for 1 h. The selected SL:LL combination was 70% (Dynasan ®114 and 118) and 30% (Miglyol ®812 and 840) for the production of SLN and NLC by high-pressure homogenization (HPH), respectively. 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