Insulin And Angiotensin Ii Signaling Pathways Cross-talk: Implications With The Association Between Diabetes Mellitus, Arterial Hypertension And Cardiovascular Disease [cross-talk Das Vias De Sinalização De Insulina E Angiotensina Ii: Implicações Com A Associação Entre Diabetes Mellitus E Hipertensão Arterial E Doença Cardiovascular]

dc.creatorDe Carvalho-Filho M.A.
dc.creatorCarvalheira J.B.C.
dc.creatorVelloso L.A.
dc.creatorSaad M.J.A.
dc.date2007
dc.date2015-06-30T18:42:29Z
dc.date2015-11-26T14:32:04Z
dc.date2015-06-30T18:42:29Z
dc.date2015-11-26T14:32:04Z
dc.date.accessioned2018-03-28T21:35:26Z
dc.date.available2018-03-28T21:35:26Z
dc.identifier
dc.identifierArquivos Brasileiros De Endocrinologia E Metabologia. , v. 51, n. 2, p. 195 - 203, 2007.
dc.identifier42730
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-34248586159&partnerID=40&md5=4ae07c51de008c3730c5c24c658ecfb1
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/104439
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/104439
dc.identifier2-s2.0-34248586159
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1247519
dc.descriptionInsulin (Ins) and angiotensin II (AII) play pivotal roles in the control of two vital and closely related systems: the metabolic and the circulatory, respectively. A failure in the proper action of each of these hormones results, to a variable degree, in the development of two highly prevalent and commonly overlapping diseases - diabetes mellitus (DM) and hypertension (AH). In recent years, a series of studies has revealed a tight connection between the signal transduction pathways that mediate Ins and AII actions in target tissues. This molecular cross-talk occurs at multiple levels and plays an important role in phenomena that range from the action of anti-hypertensive drugs to cardiac hypertrophy and energy acquisition by the heart. At the extracellular level, the angiotensin-converting enzyme controls AII synthesis but also interferes with Ins signaling through the proper regulation of AII and the accumulation of bradykinin. At an early intracellular level, AII, acting through JAK-2/IRS-1/PI3- kinase, JNK and ERK, may induce the serine phosphorylation and inhibition of key elements of the Ins-signaling pathway. Finally, by inducing the expression of the regulatory protein SOCS-3, AII may impose a late control on the Ins signal. This review will focus on the main advances obtained in this field and will discuss the implications of this molecular cross-talk in the common clinical association between DM and AH.
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dc.languagept
dc.publisher
dc.relationArquivos Brasileiros de Endocrinologia e Metabologia
dc.rightsaberto
dc.sourceScopus
dc.titleInsulin And Angiotensin Ii Signaling Pathways Cross-talk: Implications With The Association Between Diabetes Mellitus, Arterial Hypertension And Cardiovascular Disease [cross-talk Das Vias De Sinalização De Insulina E Angiotensina Ii: Implicações Com A Associação Entre Diabetes Mellitus E Hipertensão Arterial E Doença Cardiovascular]
dc.typeArtículos de revistas


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