Serological Profiles And Evaluation Of Parasitaemia By Pcr And Blood Culture In Individuals Chronically Infected By Trypanosoma Cruzi Treated With Benzonidazole

dc.creatorAguiar C.
dc.creatorBatista A.M.
dc.creatorPavan T.B.S.
dc.creatorAlmeida E.A.
dc.creatorGuariento M.E.
dc.creatorWanderley J.S.
dc.creatorCosta S.C.B.
dc.date2012
dc.date2015-06-26T20:30:36Z
dc.date2015-11-26T14:31:33Z
dc.date2015-06-26T20:30:36Z
dc.date2015-11-26T14:31:33Z
dc.date.accessioned2018-03-28T21:34:55Z
dc.date.available2018-03-28T21:34:55Z
dc.identifier
dc.identifierTropical Medicine And International Health. , v. 17, n. 3, p. 368 - 373, 2012.
dc.identifier13602276
dc.identifier10.1111/j.1365-3156.2011.02936.x
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84857359307&partnerID=40&md5=04e527ed1cdf369b113a59d4096d0a2d
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/97388
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/97388
dc.identifier2-s2.0-84857359307
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1247399
dc.descriptionObjective To evaluate the serological and parasitological status of patients with chronic Chagas disease (CD) after chemotherapy with benzonidazole. Methods Retrospective study of patients treated with benzonidazole (5mg/kg/day for 60days) between 1980 and 2010. Twenty-nine patients who had CD confirmed by two reagent immunological tests and/or one positive xenodiagnosis before treatment were included. Conventional serology (ELISA and IIF) and parasitological tests (haemoculture and N-PCR) were performed. Results At the time of treatment, the mean age of patients was 36±7.24years (20-39years) and the time post-treatment varied from 1 to 29years. After chemotherapy, all individuals had reagent ELISA and 93.1% had positive results for the IIF test. T. cruzi DNA was detected by N-PCR in 48.3%. Negative results were observed in 41.4% and inconclusive ones in 10.3%. Haemoculture was negative for all individuals. Conclusions Our results suggest that N-PCR may be useful in the early identification of therapeutic failure of CD. Although it is difficult to determine parasitological cure in negative N-PCR cases, we can infer that this condition represents a declination of parasitaemia as a favourable consequence of aetiological treatment. © 2011 Blackwell Publishing Ltd.
dc.description17
dc.description3
dc.description368
dc.description373
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dc.languageen
dc.publisher
dc.relationTropical Medicine and International Health
dc.rightsfechado
dc.sourceScopus
dc.titleSerological Profiles And Evaluation Of Parasitaemia By Pcr And Blood Culture In Individuals Chronically Infected By Trypanosoma Cruzi Treated With Benzonidazole
dc.typeArtículos de revistas


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