Influence Of Lithium On The Neuromuscular Blockade Produced By Atracurium And Cisatracurium. Study On Rat Phrenic Nerve-diaphragm Preparations [influência Do Lítio No Bloqueio Neuromuscular Produzido Pelo Atracúrio E Pelo Cisatracúrio. Estudo Em Preparações Nervo Frênico-diafragma De Rato]

dc.creatorFernandes S.C.A.
dc.creatorBraga A.D.F.D.A.
dc.creatorBraga F.S.D.S.
dc.creatorLoyola Y.C.S.
dc.creatorDe Souza S.R.
dc.creatorDe Barcelos C.C.
dc.date2007
dc.date2015-06-30T18:40:39Z
dc.date2015-11-26T14:31:19Z
dc.date2015-06-30T18:40:39Z
dc.date2015-11-26T14:31:19Z
dc.date.accessioned2018-03-28T21:34:41Z
dc.date.available2018-03-28T21:34:41Z
dc.identifier
dc.identifierRevista Brasileira De Anestesiologia. , v. 57, n. 3, p. 289 - 300, 2007.
dc.identifier347094
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-34249292997&partnerID=40&md5=2b9674420d337cbb78f288415e9e0a0d
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/104300
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/104300
dc.identifier2-s2.0-34249292997
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1247344
dc.descriptionBACKGROUND AND OBJECTIVES: Lithium is widely used for the treatment of bipolar disorders and can interact with neuromuscular blockers. There is a controversy about the mechanisms by which it affects neuromuscular transmission and its interaction with neuromuscular blockers. The objective of this study was to evaluate, on the rat diaphragm, the effects of lithium on the muscular response and indirect stimulation, and the possible interaction with neuromuscular blockers. METHODS: Rats weighing between 250 and 300 g were sacrificed under urethane anesthesia. The phrenic nerve-diaphragm preparation was assembled according to the Bulbring technique. The diaphragm was kept under tension, connected to an isometric transducer, and submitted to indirect stimulation with a frequency of 0.1 Hz. The contractions of the diaphragm were registered on a physiograph. The analysis of the amplitude of the muscular responses evaluated: the effects of the isolated drugs: lithium (1.5 mg.mL -1); atracurium (20 μg.mL-1), and cisatracurium (3 μg.mL-1); the lithium-neuromuscular blockers association; and the effects of lithium on the neuromuscular blockade produced by atracurium (35 μg.mL-1) and cisatracurium (5 μg.mL-1). The effects were evaluated before and 45 minutes after the addition of the drugs. The effects of lithium on membrane potentials (MP) and miniature end-plate potentials (MEPP) were also evaluated. RESULTS: Lithium by itself did not change the amplitude of the muscular responses, but it decreased significantly the neuromuscular blockade produced by atracurium and cisatracurium. It did not change MP and caused an initial increase in MEPP. CONCLUSIONS: Lithium by itself did not compromise neuromuscular transmission and increased the resistance to the effects of atracurium and cisatracurium. It did not show any action on the muscle fiber, and the changes in miniature end-plate potentials indicated pre-synaptic action. © Sociedade Brasileira de Anestesiologia, 2007.
dc.description57
dc.description3
dc.description289
dc.description300
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dc.languagept
dc.languageen
dc.publisher
dc.relationRevista Brasileira de Anestesiologia
dc.rightsfechado
dc.sourceScopus
dc.titleInfluence Of Lithium On The Neuromuscular Blockade Produced By Atracurium And Cisatracurium. Study On Rat Phrenic Nerve-diaphragm Preparations [influência Do Lítio No Bloqueio Neuromuscular Produzido Pelo Atracúrio E Pelo Cisatracúrio. Estudo Em Preparações Nervo Frênico-diafragma De Rato]
dc.typeArtículos de revistas


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