First, Do No Harm: The Risks Of Overtreating Children With Epilepsy

dc.creatorChuang E.
dc.creatorGuerreiro M.M.
dc.creatorTsuchie S.Y.
dc.creatorSantucci A.
dc.creatorGuerreiro C.A.M.
dc.creatorMontenegro M.A.
dc.date2007
dc.date2015-06-30T18:37:00Z
dc.date2015-11-26T14:30:15Z
dc.date2015-06-30T18:37:00Z
dc.date2015-11-26T14:30:15Z
dc.date.accessioned2018-03-28T21:33:34Z
dc.date.available2018-03-28T21:33:34Z
dc.identifier
dc.identifierArquivos De Neuro-psiquiatria. , v. 65, n. 1, p. 1 - 4, 2007.
dc.identifier0004282X
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-34147142941&partnerID=40&md5=7fd8196b283f96f20ee4ecfc02932e5b
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/104002
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/104002
dc.identifier2-s2.0-34147142941
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1247060
dc.descriptionBackground: Although overtreatment with antiepileptic drugs contributes to the morbidity associated with epilepsy, many children still are overtreated. Objective: To evaluate if the withdrawal of at least one antiepileptic drug (AED) in children with refractory epilepsy using polytherapy enable a better seizure control. Method: This was a prospective study. Children with refractory epilepsy using at least two AEDs were included. Once the patient, or guardian, agreed to participate in the study, one or more AED were slowly tapered off. The remaining AEDs dosages could be adjusted as needed, but a new AED could not be introduced. Results: Fifteen patients were evaluated, three girls; ages ranging from 3 to 18 (mean=8.7 years). After at least one AED withdrawal, two (13.5%) patients became seizure free, seizures improved >50% in 5 (33.5%) patients, did not change in 5 (33.5%), and seizure frequency became worse in 3 (20%). Adverse events improved in 12 patients (80%). Conclusion: The withdrawal of at least one AED is a valuable option in the treatment of selected children with refractory epilepsy.
dc.description65
dc.description1
dc.description1
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dc.languageen
dc.publisher
dc.relationArquivos de Neuro-Psiquiatria
dc.rightsaberto
dc.sourceScopus
dc.titleFirst, Do No Harm: The Risks Of Overtreating Children With Epilepsy
dc.typeArtículos de revistas


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