Quantifying The Pattern Of Optic Tract Degeneration In Human Hemianopia

dc.creatorMillington R.S.
dc.creatorYasuda C.L.
dc.creatorJindahra P.
dc.creatorJenkinson M.
dc.creatorBarbur J.L.
dc.creatorKennard C.
dc.creatorCendes F.
dc.creatorPlant G.T.
dc.creatorBridge H.
dc.date2014
dc.date2015-06-25T17:54:15Z
dc.date2015-11-26T14:29:59Z
dc.date2015-06-25T17:54:15Z
dc.date2015-11-26T14:29:59Z
dc.date.accessioned2018-03-28T21:33:16Z
dc.date.available2018-03-28T21:33:16Z
dc.identifier
dc.identifierJournal Of Neurology, Neurosurgery And Psychiatry. Bmj Publishing Group, v. 85, n. 4, p. 379 - 386, 2014.
dc.identifier223050
dc.identifier10.1136/jnnp-2013-306577
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84895802614&partnerID=40&md5=da45c99371be5a14ad20881325985cae
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86641
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86641
dc.identifier2-s2.0-84895802614
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1246984
dc.descriptionBackground: The existence of transsynaptic retrograde degeneration (TRD) in the human visual system has been established, however the dependence of TRD on different factors such as lesion location, size and manner of lesion acquisition has yet to be quantified. Methods: We obtained T1-weighted structural and diffusion-weighted images for 26 patients with adultacquired or congenital hemianopia and 12 age-matched controls. The optic tract (OT) was defined and measured in the structural and diffusion-weighted images, and degeneration assessed by comparing the integrity of tracts in the lesioned and in the undamaged hemisphere. Results: OT degeneration was found in all patients with established lesions, regardless of lesion location. In patients with acquired lesions, the larger the initial lesion, the greater is the resulting TRD. However, this was not the case for congenital patients, who generally showed greater degeneration than would be predicted by lesion size. A better predictor of TRD was the size of the visual field deficit, which was correlated with degeneration across all patients. Interestingly, although diffusion-weighted imaging (DWI) is more frequently used to examine white matter tracts, in this study the T1- weighted scans gave a better indication of the extent of tract degeneration. Conclusions: We conclude that TRD of the OT occurs in acquired and congenital hemianopia, is correlated with visual field loss, and is most severe in congenital cases. Understanding the pattern of TRD may help to predict effects of any visual rehabilitation training.
dc.description85
dc.description4
dc.description379
dc.description386
dc.descriptionNIHR; National Institute for Health Research
dc.descriptionZhang, X., Kedar, S., Lynn, M.J., Newman, N.J., Biousse, V., Homonymous hemianopia in stroke (2006) Journal of Neuro-Ophthalmology, 26 (3), pp. 180-183. , DOI 10.1097/01.wno.0000235587.41040.39, PII 0004132720060900000005
dc.descriptionLuu, S., Lee, A.W., Daly, A., Visual field defects after stroke: A practical guide for GPs (2010) Aust Fam Physician, 39, pp. 499-503
dc.descriptionPambakian, A.L.M., Kennard, C., Can visual function be restored in patients with homonymous hemianopia? (1997) British Journal of Ophthalmology, 81 (4), pp. 324-328
dc.descriptionZhang, X., Kedar, S., Lynn, M.J., Newman, N.J., Biousse, V., Natural history of homonymous hemianopia (2006) Neurology, 66 (6), pp. 901-905. , DOI 10.1212/01.wnl.0000203338.54323.22, PII 0000611420060328000023
dc.descriptionSchofield, T.M., Leff, A.P., Rehabilitation of hemianopia (2009) Curr Opin Neurol, 22, pp. 36-40
dc.descriptionAjina, S., Kennard, C., Rehabilitation of damage to the visual brain (2012) Rev Neurol, 168, pp. 754-761
dc.descriptionMueller, I., Mast, H., Sabel, B.A., Recovery of visual field defects: A large clinical observational study using vision restoration therapy (2007) Restorative Neurology and Neuroscience, 25 (5-6), pp. 563-572
dc.descriptionSahraie, A., Macleod, M.J., Trevethan, C.T., Improved detection following Neuro-Eye Therapy in patients with post-geniculate brain damage (2010) Exp Brain Res, 206, pp. 25-34
dc.descriptionVanburen, J.M., Trans-synaptic retrograde degeneration in the visual system of primates (1963) J Neurol Neurosurg Psychiatry, 26, pp. 402-409
dc.descriptionWeller, R.E., Kaas, J.H., Parameters affecting the loss of ganglion cells of the retina following ablations of striate cortex in primates (1989) Vis Neurosci, 3, pp. 327-349
dc.descriptionCowey, A., Stoerig, P., Williams, C., Variance in transneuronal retrograde ganglion cell degeneration in monkeys after removal of striate cortex: Effects of size of the cortical lesion (1999) Vision Research, 39 (21), pp. 3642-3652. , DOI 10.1016/S0042-6989(99)00097-8, PII S0042698999000978
dc.descriptionCowey, A., Alexander, I., Stoerig, P., Transneuronal retrograde degeneration of retinal ganglion cells and optic tract in hemianopic monkeys and humans (2011) Brain, 134, pp. 2149-2157
dc.descriptionCowey, A., Stoerig, P., Perry, V.H., Transneuronal retrograde degeneration of retinal ganglion cells after damage to striate cortex in macaque monkeys: Selective loss of Pβ cells (1989) Neuroscience, 29 (1), pp. 65-80. , DOI 10.1016/0306-4522(89)90333-3
dc.descriptionBridge, H., Plant, G., Conclusive Evidence for Human Transneuronal Retrograde Degeneration in the Visual System (2012) J Clin Exp Ophthalmol, 3 S, p. 003
dc.descriptionJindahra, P., Petrie, A., Plant, G.T., Retrograde trans-synaptic retinal ganglion cell loss identi fied by optical coherence tomography (2009) Brain, 132, pp. 628-634
dc.descriptionJindahra, P., Petrie, A., Plant, G.T., The time course of retrograde trans-synaptic degeneration following occipital lobe damage in humans (2012) Brain, 135, pp. 534-541
dc.descriptionJindahra, P., Petrie, A., Plant, G.T., Thinning of the retinal nerve fibre layer in homonymous quadrantanopia: Further evidence for retrograde trans-synaptic degeneration in the human visual system (2012) J Neuroophthalmol, 36, pp. 79-84
dc.descriptionBridge, H., Jindahra, P., Barbur, J., Imaging reveals optic tract degeneration in Hemianopia (2011) Invest Ophthalmol Vis Sci, 52, pp. 382-388
dc.descriptionBehrens, T.E.J., Berg, H.J., Jbabdi, S., Rushworth, M.F.S., Woolrich, M.W., Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? (2007) NeuroImage, 34 (1), pp. 144-155. , DOI 10.1016/j.neuroimage.2006.09.018, PII S1053811906009360
dc.descriptionBehrens, T.E.J., Woolrich, M.W., Jenkinson, M., Johansen-Berg, H., Nunes, R.G., Clare, S., Matthews, P.M., Smith, S.M., Characterization and Propagation of Uncertainty in Diffusion-Weighted MR Imaging (2003) Magnetic Resonance in Medicine, 50 (5), pp. 1077-1088. , DOI 10.1002/mrm.10609
dc.descriptionBurgel, U., Amunts, K., Hoemke, L., Mohlberg, H., Gilsbach, J.M., Zilles, K., White matter fiber tracts of the human brain: Three-dimensional mapping at microscopic resolution, topography and intersubject variability (2006) NeuroImage, 29 (4), pp. 1092-1105. , DOI 10.1016/j.neuroimage.2005.08.040, PII S105381190500649X
dc.descriptionSmith, S.M., Jenkinson, M., Johansen-Berg, H., Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data (2006) NeuroImage, 31, pp. 1487-1505
dc.descriptionHoyt, C.S., Visual function in the brain-damaged child (2003) Eye, 17 (3), pp. 369-384. , DOI 10.1038/sj.eye.6700364
dc.descriptionCowey, A., Stoerig, P., The neurobiology of blindsight (1991) Trends Neurosci, 14, pp. 140-145
dc.descriptionWarner, C.E., Kwan, W.C., Bourne, J.A., The early maturation of visual cortical area MT is dependent on input from the retinorecipient medial portion of the inferior pulvinar (2012) J Neurosci, 32, pp. 17073-17085
dc.descriptionSchmid, M.C., Mrowka, S.W., Turchi, J., Blindsight depends on the lateral geniculate nucleus (2010) Nature, 466, pp. 373-377
dc.descriptionBridge, H., Thomas, O., Jbabdi, S., Cowey, A., Changes in connectivity after visual cortical brain damage underlie altered visual function (2008) Brain, 131 (6), pp. 1433-1444. , DOI 10.1093/brain/awn063
dc.descriptionSincich, L.C., Park, K.F., Wohlgemuth, M.J., Horton, J.C., Bypassing V1: A direct geniculate input to area MT (2004) Nature Neuroscience, 7 (10), pp. 1123-1128. , DOI 10.1038/nn1318
dc.descriptionBridge, H., Hicks, S.L., Xie, J., Visual activation of extra-striate cortex in the absence of V1 activation (2010) Neuropsychologia, 48, pp. 4148-4154
dc.languageen
dc.publisherBMJ Publishing Group
dc.relationJournal of Neurology, Neurosurgery and Psychiatry
dc.rightsfechado
dc.sourceScopus
dc.titleQuantifying The Pattern Of Optic Tract Degeneration In Human Hemianopia
dc.typeArtículos de revistas


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