12-month Follow-up Analysis Of A Multicenter, Randomized, Prospective Trial In De Novo Liver Transplantation Recipients (lis2t) Comparing Cyclosporine Microemulsion (c2 Monitoring) And Tacrolimus

dc.creatorLevy G.
dc.creatorGrazi G.L.
dc.creatorSanjuan F.
dc.creatorWu Y.
dc.creatorMuhlbacher F.
dc.creatorSamuel D.
dc.creatorFriman S.
dc.creatorJones R.
dc.creatorCantisani G.
dc.creatorVillamil F.
dc.creatorCillo U.
dc.creatorClavien P.A.
dc.creatorKlintmalm G.
dc.creatorOtto G.
dc.creatorPollard S.
dc.creatorMcCormick P.A.
dc.creatorDescalsi V.
dc.creatorGadano A.
dc.creatorVillamil A.
dc.creatorAngus P.
dc.creatorLynch S.
dc.creatorBalderson G.A.
dc.creatorJeffreys G.
dc.creatorChester B.
dc.creatorSteininger R.
dc.creatorde Hemptinne B.
dc.creatorTroisi R.
dc.creatorZanotelli M.L.
dc.creatorLeonardi L.
dc.creatorBoin I.
dc.creatorMies S.
dc.creatorGuardia B.D.
dc.creatorLilly L.
dc.creatorMarotta P.
dc.creatorWall W.
dc.creatorPeltekian K.
dc.creatorRoy A.
dc.creatorMarleau D.
dc.creatorScudamore C.
dc.creatorYoshida M.
dc.creatorTchervenkov J.
dc.creatorCantarovich M.
dc.creatorBoillot O.
dc.creatorBernard P.
dc.creatorCalmus Y.
dc.creatorConti F.
dc.creatorCherqui D.
dc.creatorDuvoux C.
dc.creatorDucerf C.
dc.creatorMaar R.
dc.creatorGugenheim J.
dc.creatorMyx A.
dc.creatorNeau-Cransac D.
dc.creatorMouette K.
dc.creatorSaliba F.
dc.creatorRostaing L.
dc.creatorKamar N.
dc.creatorMoench C.
dc.creatorO'Rourke M.
dc.creatorD'Amico D.
dc.creatorVarotti G.
dc.creatorMaffei-Faccioli A.
dc.creatorGerunda G.
dc.creatorMerenda R.
dc.creatorRisaliti A.
dc.creatorBaccarani U.
dc.creatorRossi M.
dc.creatorBerloco P.
dc.creatorTanaka K.
dc.creatorOike F.
dc.creatorMunn S.
dc.creatorGane E.
dc.creatorBrekke I.
dc.creatorBoberg K.M.
dc.creatorBernardos A.
dc.creatorGarcia I.
dc.creatorCuervas V.
dc.creatorMoreno J.M.
dc.creatorRimola A.
dc.creatorCirera I.
dc.creatorSanjuan F.
dc.creatorPrieto M.
dc.creatorSalcedo M.
dc.creatorClemente G.
dc.creatorEricson B.
dc.creatorGjertsen H.
dc.creatorHerlenius G.
dc.creatorKadry Z.
dc.creatorMayer D.
dc.creatorHayes P.
dc.creatorDavidson J.
dc.creatorHodgson J.
dc.creatorBynon J.S.
dc.creatorDavis G.
dc.creatorOrtiz J.
dc.creatorManzarbeita C.
dc.creatorMennon R.
dc.creatorWeisner R.H.
dc.creatorWu Y.
dc.creatorChensu R.-Y.
dc.creatorLake J.R.
dc.creatorHumar A.
dc.date2006
dc.date2015-06-30T18:17:06Z
dc.date2015-11-26T14:29:00Z
dc.date2015-06-30T18:17:06Z
dc.date2015-11-26T14:29:00Z
dc.date.accessioned2018-03-28T21:32:13Z
dc.date.available2018-03-28T21:32:13Z
dc.identifier
dc.identifierLiver Transplantation. , v. 12, n. 10, p. 1464 - 1472, 2006.
dc.identifier15276465
dc.identifier10.1002/lt.20802
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-33750112891&partnerID=40&md5=ce03c56aadd27167947e6f5c798fa8e0
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/103830
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/103830
dc.identifier2-s2.0-33750112891
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1246738
dc.descriptionThe LIS2T study was an open-label, multicenter study in which recipients of a primary liver transplant were randomized to cyclosporine microemulsion (CsA-ME) (Neural) (n = 250) (monitoring of blood concentration at 2 hours postdose) C2 or tacrolimus (n = 245) (monitoring of trough drug blood level[predose])Co to compare efficacy and safety at 3 and 6 months and to evaluate patient status at 12 months. All patients received steroids with or without azathioprine. At 12 months, 85% of CsA-ME patients and 86% o tacrolimus patients survived with a functioning grat (P not significant). Efficacy was similar in deceased-and living-donor recipients. Significantly fewer hepatitis C-positive patients died or lost their graft by 12 months with CsA-ME 95/ 88,6%) than with tacrolimus (14/85,16%) (P< 0.03). Recurrence of hepatitis C virus in liver grafts was similar in each group. Based on biopsies driven by clinical events, the mean time to histological diagnosis of hepatitis C virus recurrence was significantly longer with CsA-ME (100 ± 50 days) than with tacrolimus (70 ± 40 days) (P < 0.05). Median serum creatinine at 12 months was 106 μmol/L with CsA-ME and with tacrolimus. More patients who were nondiabetic at baseline received antihyperglycemic therapy in the tacrolimus group at 12 months was (13% vs. 5%, P< 0.01). Of patients who were diabetic at baseline, more tacrolimus-treated individuals required anti-diabetic treatment at 12 months ( 70% vs. 49%, P+ 0.02). Treatment for de novo or preexisting hypertension or hyperlipidemia was similar in both groups. In conclusion, the efficacy of CsA-ME monitored by blood concentration at 2 hours postdose and tacrolimus in liver transplant patients is equivalent to 12 months, and renal function is similar. More patients required antidiabetic therapy with tacrolimus regardless of diabetic status at baseline. © 2006 AASLD.
dc.description12
dc.description10
dc.description1464
dc.description1472
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dc.languageen
dc.publisher
dc.relationLiver Transplantation
dc.rightsfechado
dc.sourceScopus
dc.title12-month Follow-up Analysis Of A Multicenter, Randomized, Prospective Trial In De Novo Liver Transplantation Recipients (lis2t) Comparing Cyclosporine Microemulsion (c2 Monitoring) And Tacrolimus
dc.typeArtículos de revistas


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