Styryl Lactones And Their Derivatives: Biological Activities, Mechanisms Of Action And Potential Leads For Drug Design

dc.creatorde Fatima A.
dc.creatorModolo L.V.
dc.creatorConegero L.S.
dc.creatorPilli R.A.
dc.creatorFerreira C.V.
dc.creatorKohn L.K.
dc.creatorde Carvalho J.E.
dc.date2006
dc.date2015-06-30T18:14:03Z
dc.date2015-11-26T14:28:04Z
dc.date2015-06-30T18:14:03Z
dc.date2015-11-26T14:28:04Z
dc.date.accessioned2018-03-28T21:31:14Z
dc.date.available2018-03-28T21:31:14Z
dc.identifier
dc.identifierCurrent Medicinal Chemistry. , v. 13, n. 28, p. 3371 - 3384, 2006.
dc.identifier9298673
dc.identifier10.2174/092986706779010298
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-33845370152&partnerID=40&md5=b6f602980e6216583c527e3242747907
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/103612
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/103612
dc.identifier2-s2.0-33845370152
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1246499
dc.descriptionNature is an inexhaustible source of natural compounds with interesting biological activities. In general, natural products are an important source of new compounds with a variety of structural arrangements and singular properties. Styryl lactones are a group of secondary metabolites ubiquitous in the genus Goniothalamus that have demonstrated to possess interesting biological properties, in particular antiproliferative activity against cancer cells. In general, the cytotoxicity of styryl lactones appears to be specific against cancer cells since insignificant effects of thew compounds on normal cells are reported. A large body of evidence suggests that the antiproliferative activity of styryl lactones is associated, with the induction of apoptosis in target cells. In the first part of this review we discuss the biological activities of styryl lactones focusing on cancer cells, the causal agent of Chagas' disease and the vectors for yellow fever and human lymphatic filariasis. Structure-activity relationships are described in detail for ninety styryl lactones. The last part describes the molecular targets of styryl lactones for inducing apoptosis, as well as immunosuppressive and inflammatory processes. Overall, understanding how these compounds exert their activities in biological system is essential for future development and application of styryl lactones for human health. © 2006 Bentham Science Publishers Ltd.
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dc.languageen
dc.publisher
dc.relationCurrent Medicinal Chemistry
dc.rightsfechado
dc.sourceScopus
dc.titleStyryl Lactones And Their Derivatives: Biological Activities, Mechanisms Of Action And Potential Leads For Drug Design
dc.typeArtículos de revistas


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