| dc.creator | Oliveira M.A. | |
| dc.date | 2014 | |
| dc.date | 2015-06-25T17:53:57Z | |
| dc.date | 2015-11-26T14:27:47Z | |
| dc.date | 2015-06-25T17:53:57Z | |
| dc.date | 2015-11-26T14:27:47Z | |
| dc.date.accessioned | 2018-03-28T21:30:54Z | |
| dc.date.available | 2018-03-28T21:30:54Z | |
| dc.identifier | | |
| dc.identifier | Revista Brasileira De Cirurgia Cardiovascular : órgão Oficial Da Sociedade Brasileira De Cirurgia Cardiovascular. , v. 29, n. 1, p. 83 - 88, 2014. | |
| dc.identifier | 16789741 | |
| dc.identifier | | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84922022824&partnerID=40&md5=6d089869ea2f3c1bd8092a120c9f3efe | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/86562 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/86562 | |
| dc.identifier | 2-s2.0-84922022824 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1246418 | |
| dc.description | INTRODUCTION: Cardiac arrest during heart surgery is a common procedure and allows the surgeon to perform surgical procedures in an environment free of blood and movement. Using a model of isolated rat heart, the authors compare a new cardioplegic solution containing histidine-tryptophan-glutamate (group 2) with the histidine-tryptophan-alphacetoglutarate (group 1) routinely used by some cardiac surgeons.OBJECTIVE: To assess caspase, IL-8 and KI-67 in isolated rat hearts using immunohistochemistry.METHODS: 20 Wistar male rats were anesthetized and heparinized. The chest was opened, cardioctomy was performed and 40 ml/kg of the appropriate cardioplegic solution was infused. The hearts were kept for 2 hours at 4ºC in the same solution, and thereafter, placed in the Langendorff apparatus for 30 minutes with Ringer-Locke solution. Immunohistochemistry analysis of caspase, IL-8, and KI-67 were performed.RESULTS: The concentration of caspase was lower in group 2 and Ki-67 was higher in group 2, both P<0.05. There was no statistical difference between the values of IL-8 between the groups.CONCLUSION: Histidine-tryptophan-glutamate solution was better than histidine-tryptophan-alphacetoglutarate solution because it reduced caspase (apoptosis), increased KI-67 (cell proliferation), and showed no difference in IL-8 levels compared to group 1. This suggests that the histidine-tryptophan-glutamate solution was more efficient than the histidine-tryptophan-alphacetoglutarate for the preservation of hearts of rat cardiomyocytes. | |
| dc.description | 29 | |
| dc.description | 1 | |
| dc.description | 83 | |
| dc.description | 88 | |
| dc.language | en | |
| dc.language | pt | |
| dc.publisher | | |
| dc.relation | Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular | |
| dc.rights | aberto | |
| dc.source | Scopus | |
| dc.title | Comparison Of The Solution Of Histidine-tryptophan-alfacetoglutarate With Histidine-tryptophan-glutamate As Cardioplegic Agents In Isolated Rat Hearts: An Immunohistochemical Study | |
| dc.type | Artículos de revistas | |
