| dc.creator | Oliveira-Ribeiro M. | |
| dc.creator | Petta C.A. | |
| dc.creator | De Angelo Andrade L.A.L. | |
| dc.creator | Hidalgo M.M. | |
| dc.creator | Pellogia A. | |
| dc.creator | Bahamondes L. | |
| dc.date | 2006 | |
| dc.date | 2015-06-30T18:11:38Z | |
| dc.date | 2015-11-26T14:27:04Z | |
| dc.date | 2015-06-30T18:11:38Z | |
| dc.date | 2015-11-26T14:27:04Z | |
| dc.date.accessioned | 2018-03-28T21:30:08Z | |
| dc.date.available | 2018-03-28T21:30:08Z | |
| dc.identifier | | |
| dc.identifier | Contraception. , v. 73, n. 6, p. 634 - 640, 2006. | |
| dc.identifier | 107824 | |
| dc.identifier | 10.1016/j.contraception.2005.10.013 | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-33646757891&partnerID=40&md5=87a2321fbe200386b19b50ea9f24f771 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/103440 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/103440 | |
| dc.identifier | 2-s2.0-33646757891 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1246235 | |
| dc.description | Objective: This descriptive study evaluated endometrial histology, microvascular density and caliber, and quantification of matrix metalloproteinase (MMP-3) expression in long-term users of the Nestorone® (NES)-releasing implant who presented or not endometrial breakthrough bleeding (BTB). Methods: Endometrial biopsies were obtained from 32 healthy women with unpredictable BTB. The quantitative analysis was performed only in 20 samples. Results: The mean duration of use of the implant among the 14 women with BTB was 19.6±1.0 months, and the other six women had used the implant for 17.7±2.3 months (mean±S.E.M.). Histological analysis of the endometrial tissue showed a predominance of progestogenic pattern followed by atrophic and proliferative endometrium in both groups. Mucosal breakdown and glandular pseudostratification were observed in half of the cases. Endometrial vascular density was 73.1±10.0 and 57.5±24.1 vessels/mm2, and maximum vessel diameter was 923.3±86.0 and 1038.0±404 μm (mean±S.E.M.) in the group with and without BTB, respectively, without significance, and the rate of cells expressing MMP-3×1000 counted stromal cells was 155.8±24.8 and 127.0±19.0 (mean±S.E.M.) in both groups, respectively, without significance. Conclusions: This study provides information about some endometrial aspects of women using NES in contraceptive implants. In addition, the endometrium was similar during long-term use of NES-releasing contraceptive implants in women with and without endometrial bleeding. © 2006 Elsevier Inc. All rights reserved. | |
| dc.description | 73 | |
| dc.description | 6 | |
| dc.description | 634 | |
| dc.description | 640 | |
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| dc.language | en | |
| dc.publisher | | |
| dc.relation | Contraception | |
| dc.rights | fechado | |
| dc.source | Scopus | |
| dc.title | Endometrial Histology, Microvascular Density And Caliber, And Matrix Metalloproteinase-3 In Users Of The Nestorone®-releasing Contraceptive Implant With And Without Endometrial Breakthrough Bleeding | |
| dc.type | Artículos de revistas | |
