| dc.creator | De Almeida A.C. | |
| dc.creator | Barbosa S.M. | |
| dc.creator | De Lourdes Rios Barjas-Castro M. | |
| dc.creator | Olalla-Saad S.T. | |
| dc.creator | Condino-Neto A. | |
| dc.date | 2012 | |
| dc.date | 2015-06-26T20:30:03Z | |
| dc.date | 2015-11-26T14:26:59Z | |
| dc.date | 2015-06-26T20:30:03Z | |
| dc.date | 2015-11-26T14:26:59Z | |
| dc.date.accessioned | 2018-03-28T21:30:04Z | |
| dc.date.available | 2018-03-28T21:30:04Z | |
| dc.identifier | | |
| dc.identifier | Immunopharmacology And Immunotoxicology. , v. 34, n. 6, p. 1054 - 1059, 2012. | |
| dc.identifier | 8923973 | |
| dc.identifier | 10.3109/08923973.2012.697470 | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84868137227&partnerID=40&md5=029c05a77d4514e347f03696e1f19815 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/97213 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/97213 | |
| dc.identifier | 2-s2.0-84868137227 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1246216 | |
| dc.description | Background: Many cases of autoimmune hemolytic anemia have been reported after viral infection. Phagocyte activation and accompanying erythrophagocytosis are thought to result from proinflammatory cytokines released during viral infection. SIRP-α (signal regulatory protein-α), a receptor expressed on phagocytes, inhibits phagocytosis when bound to CD47 on the erythrocyte membrane. Ligation with CD47 results in SHP-1 recruitment to SIRP-α and dephosphorylation of specific downstream substrates involved in phagocytosis. SIRP-α ligation by CD47 may be inhibited by proinflammatory cytokines. Objectives: The aim of this work was to evaluate the effect of IFN-β, IFN-γ, and TNF-α on erythrophagocytosis and assess the effect on expression of SIRP-α and SHP-1 in human monocytes. Materials and methods: Monocytes were cultured ex vivo with IFN-β or IFN-γ/TNF-α. Erythrophagocytosis was determined by flow cytometry. SIRP-α and SHP-1 gene expression was determined by real time-PCR, while SIRP-α and SHP-1 protein expression was determined by western blot. Results: Erythrophagocytosis by monocytes significantly decreased after treatment with either IFN-β or IFN-γ/TNF-α. Monocytes cultured with IFN-γ/TNF-α showed increased SIRP-α gene and protein expression and SHP-1 gene expression. Monocytes cultured with IFN-β did not show any alteration in SIRP-α or SHP-1 expression. Conclusion: We conclude that IFN-β and IFN-γ/TNF-α decrease erythrophagocytosis by human monocytes in vitro, and this effect does not apparently require an increase in SIRP-α or SHP-1 expression. © 2012 Informa Healthcare USA, Inc. | |
| dc.description | 34 | |
| dc.description | 6 | |
| dc.description | 1054 | |
| dc.description | 1059 | |
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| dc.language | en | |
| dc.publisher | | |
| dc.relation | Immunopharmacology and Immunotoxicology | |
| dc.rights | fechado | |
| dc.source | Scopus | |
| dc.title | Ifn-β, Ifn-γ, And Tnf-α Decrease Erythrophagocytosis By Human Monocytes Independent Of Sirp-α Or Shp-1 Expression | |
| dc.type | Artículos de revistas | |
