Levels And Patterns Of Expression Of Hypoxia-inducible Factor-1α, Vascular Endothelial Growth Factor, Glucose Transporter-1 And Cd105 In Adenoid Cystic Carcinomas With High-grade Transformation

dc.creatorCosta A.F.
dc.creatorTasso M.G.
dc.creatorMariano F.V.
dc.creatorSoares A.B.
dc.creatorChone C.T.
dc.creatorCrespo A.N.
dc.creatorFresno M.F.
dc.creatorLlorente J.L.
dc.creatorSuarez C.
dc.creatorde Araujo V.C.
dc.creatorHermsen M.
dc.creatorAltemani A.
dc.date2012
dc.date2015-06-26T20:29:40Z
dc.date2015-11-26T14:26:03Z
dc.date2015-06-26T20:29:40Z
dc.date2015-11-26T14:26:03Z
dc.date.accessioned2018-03-28T21:28:55Z
dc.date.available2018-03-28T21:28:55Z
dc.identifier
dc.identifierHistopathology. , v. 60, n. 5, p. 816 - 825, 2012.
dc.identifier3090167
dc.identifier10.1111/j.1365-2559.2011.04128.x
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84859006688&partnerID=40&md5=449a680b41cd3f77924d2217d43910c1
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/97120
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/97120
dc.identifier2-s2.0-84859006688
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1245955
dc.descriptionAims: To compare the expression of proteins regulated by hypoxia between adenoid cystic carcinoma (ACC) with and without high-grade transformation (HGT). Methods and results: In eight ACC-HGT and 18 ACC without HGT, expression of hypoxia-inducible factor-1 (HIF-1α), vascular endothelial growth factor (VEGF), glucose transporter-1 (GLUT-1) and microvascular density (MVD) by CD105 (a hypoxia-inducible protein expressed in angiogenic endothelial cells) was determined. Expression levels of HIF-1α and VEGF as well as CD105-MVD did not differ significantly between: (i) transformed and conventional areas (TA and CA, respectively) of ACC-HGT, (ii) CA and ordinary ACC. HIF-1α was detected in 100% of cases and presented a diffuse expression pattern. No significant association was found between levels of HIF-1α expression and tumour size, metastasis and recurrence. GLUT-1 showed a prostromal expression pattern and was observed exclusively in TA (three of six cases) and in only three of 14 ACC. Conclusions: Both the absence of significant alterations in levels of expression of HIF-1α, VEGF and CD105 and the patterns of expression of HIF-1α and GLUT-1 suggest that hypoxia may not play a key role in the process of high-grade transformation of ACC. Although HIF-1α expression is a common finding in ACC, it cannot be used as a marker of tumour aggressiveness. © 2012 Blackwell Publishing Limited.
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dc.languageen
dc.publisher
dc.relationHistopathology
dc.rightsfechado
dc.sourceScopus
dc.titleLevels And Patterns Of Expression Of Hypoxia-inducible Factor-1α, Vascular Endothelial Growth Factor, Glucose Transporter-1 And Cd105 In Adenoid Cystic Carcinomas With High-grade Transformation
dc.typeArtículos de revistas


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