Artículos de revistas
On The Pathogenesis Of Plasmodium Vivax Malaria: Perspectives From The Brazilian Field
Registro en:
International Journal For Parasitology. , v. 42, n. 12, p. 1099 - 1105, 2012.
207519
10.1016/j.ijpara.2012.08.007
2-s2.0-84869888762
Autor
Costa F.T.M.
Lopes S.C.P.
Albrecht L.
Ataide R.
Siqueira A.M.
Souza R.M.
Russell B.
Renia L.
Marinho C.R.F.
Lacerda M.V.G.
Institución
Resumen
Life-threatening Plasmodium vivax malaria cases, while uncommon, have been reported since the early 20th century. Unfortunately, the pathogenesis of these severe vivax malaria cases is still poorly understood. In Brazil, the proportion of vivax malaria cases has been steadily increasing, as have the number of cases presenting serious clinical complications. The most frequent syndromes associated with severe vivax malaria in Brazil are severe anaemia and acute respiratory distress. Additionally, P. vivax infection may also result in complications associated with pregnancy. Here, we review the latest findings on severe vivax malaria in Brazil. We also discuss how the development of targeted field research infrastructure in Brazil is providing clinical and ex vivo experimental data that benefits local and international efforts to understand the pathogenesis of P. vivax. © 2012 Australian Society for Parasitology Inc. 42 12 1099 1105 Alexandre, M.A., Ferreira, C.O., Siqueira, A.M., Magalhaes, B.L., Mourao, M.P., Lacerda, M.V., Alecrim, M.G., Severe Plasmodium vivax malaria, Brazilian Amazon (2010) Emerg. Infect. Dis., 16, pp. 1611-1614 Alves, F.P., Durlacher, R.R., Menezes, M.J., Krieger, H., Silva, L.H., Camargo, E.P., High prevalence of asymptomatic Plasmodium vivax and Plasmodium falciparum infections in native Amazonian populations (2002) Am. J. Trop. Med. Hyg., 66, pp. 641-648 Andrade, B.B., Reis-Filho, A., Souza-Neto, S.M., Clarencio, J., Camargo, L.M., Barral, A., Barral-Netto, M., Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance (2010) Malar. J., 9, p. 13 Andrade, B.B., Barral-Netto, M., Biomarkers for susceptibility to infection and disease severity in human malaria (2011) Mem. Inst. Oswaldo Cruz, 106 (SUPPL. 1), pp. 70-78 Anstey, N.M., Handojo, T., Pain, M.C., Kenangalem, E., Tjitra, E., Price, R.N., Maguire, G.P., Lung injury in vivax malaria: pathophysiological evidence for pulmonary vascular sequestration and posttreatment alveolar-capillary inflammation (2007) J. Infect. Dis., 195, pp. 589-596 Anstey, N.M., Russell, B., Yeo, T.W., Price, R.N., The pathophysiology of vivax malaria (2009) Trends Parasitol., 25, pp. 220-227 Berendt, A.R., Ferguson, D.J., Newbold, C.I., Sequestration in Plasmodium falciparum malaria: sticky cells and sticky problems (1990) Parasitol. Today, 6, pp. 247-254 Bernabeu, M., Lopez, F.J., Ferrer, M., Martin-Jaular, L., Razaname, A., Corradin, G., Maier, A.G., Fernandez-Becerra, C., Functional analysis of Plasmodium vivax VIR proteins reveals different subcellular localizations and cytoadherence to the ICAM-1 endothelial receptor (2012) Cell Microbiol., 14, pp. 386-400 Camargo, L.M., Ferreira, M.U., Krieger, H., De Camargo, E.P., Da Silva, L.P., Unstable hypoendemic malaria in Rondonia (western Amazon region, Brazil): epidemic outbreaks and work-associated incidence in an agro-industrial rural settlement (1994) Am. J. Trop. Med. Hyg., 51, pp. 16-25 Campos, F.M., Franklin, B.S., Teixeira-Carvalho, A., Filho, A.L., de Paula, S.C., Fontes, C.J., Brito, C.F., Carvalho, L.H., Augmented plasma microparticles during acute Plasmodium vivax infection (2010) Malar. J., 9, p. 327 Campos, I.M., Uribe, M.L., Cuesta, C., Franco-Gallego, A., Carmona-Fonseca, J., Maestre, A., Diagnosis of gestational, congenital, and placental malaria in Colombia: comparison of the efficacy of microscopy, nested polymerase chain reaction, and histopathology (2011) Am. J. Trop. Med. Hyg., 84, pp. 929-935 Carvalho, B.O., Lopes, S.C., Nogueira, P.A., Orlandi, P.P., Bargieri, D.Y., Blanco, Y.C., Mamoni, R., Costa, F.T., On the cytoadhesion of Plasmodium vivax-infected erythrocytes (2010) J. Infect. Dis., 202, pp. 638-647 Carvalho, B.O., Matsuda, J.S., Luz, S.L., Martinez-Espinosa, F.E., Leite, J.A., Franzin, F., Orlandi, P.P., Costa, F.T., Gestational malaria associated to Plasmodium vivax and Plasmodium falciparum placental mixed-infection followed by foetal loss: a case report from an unstable transmission area in Brazil (2011) Malar. J., 10, p. 178 Cavasini, C.E., Mattos, L.C., Couto, A.A., Bonini-Domingos, C.R., Valencia, S.H., Neiras, W.C., Alves, R.T., Machado, R.L., Plasmodium vivax infection among Duffy antigen-negative individuals from the Brazilian Amazon region: an exception? (2007) Trans. R. Soc. Trop. Med. Hyg., 101, pp. 1042-1044 Chagas, E.C., do Nascimento, C.T., de Santana Filho, F.S., Botto-Menezes, C.H., Martinez-Espinosa, F.E., Impact of malaria during pregnancy in the Amazon region (2009) Rev. Panam. Salud Publica, 26, pp. 203-208 Chotivanich, K.T., Pukrittayakamee, S., Simpson, J.A., White, N.J., Udomsangpetch, R., Characteristics of Plasmodium vivax-infected erythrocyte rosettes (1998) Am. J. Trop. Med. Hyg., 59, pp. 73-76 Chotivanich, K., Udomsangpetch, R., Suwanarusk, R., Pukrittayakamee, S., Wilairatana, P., Beeson, J.G., Day, N.P., White, N.J., Plasmodium vivax adherence to placental glycosaminoglycans (2012) PLoS One, 7, pp. e34509 Collins, W.E., Jeffery, G.M., Roberts, J.M., A retrospective examination of anemia during infection of humans with Plasmodium vivax (2003) Am. J. Trop. Med. Hyg., 68, pp. 410-412 Costa, K.M., Almeida, W.A., Magalhaes, I.B., Montoya, R., Moura, M.S., Lacerda, M.V., Malaria in Cruzeiro do Sul (Western Brazilian Amazon): analysis of the historical series from 1998 to 2008 (2010) Rev. Panam. Salud Publica, 28, pp. 353-360 da Silva-Nunes, M., Codeco, C.T., Malafronte, R.S., da Silva, N.S., Juncansen, C., Muniz, P.T., Ferreira, M.U., Malaria on the Amazonian frontier: transmission dynamics, risk factors, spatial distribution, and prospects for control (2008) Am. J. Trop. Med. Hyg., 79, pp. 624-635 de Santana Filho, F.S., Arcanjo, A.R., Chehuan, Y.M., Costa, M.R., Martinez-Espinosa, F.E., Vieira, J.L., Barbosa, M.G., Alecrim, M.G., Chloroquine-resistant Plasmodium vivax, Brazilian Amazon (2007) Emerg. Infect. Dis., 13, pp. 1125-1126 del Portillo, H.A., Fernandez-Becerra, C., Bowman, S., Oliver, K., Preuss, M., Sanchez, C.P., Schneider, N.K., Lanzer, M., A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax (2001) Nature, 410, pp. 839-842 del Portillo, H.A., Lanzer, M., Rodriguez-Malaga, S., Zavala, F., Fernandez-Becerra, C., Variant genes and the spleen in Plasmodium vivax malaria (2004) Int. J. Parasitol., 34, pp. 1547-1554 Fernandez-Becerra, C., Pein, O., de Oliveira, T.R., Yamamoto, M.M., Cassola, A.C., Rocha, C., Soares, I.S., del Portillo, H.A., Variant proteins of Plasmodium vivax are not clonally expressed in natural infections (2005) Mol. Microbiol., 58, pp. 648-658 Fernandez-Becerra, C., Pinazo, M.J., Gonzalez, A., Alonso, P.L., del Portillo, H.A., Gascon, J., Increased expression levels of the pvcrt-o and pvmdr1 genes in a patient with severe Plasmodium vivax malaria (2009) Malar. J., 8, p. 55 Ferreira Goncalves, M.J., Alecrim, W.D., Non-planed urbanization as a contributing factor for malaria incidence in Manaus-Amazonas (2004) Braz. Rev. Salud Publica (Bogota), 6, pp. 156-166 Field, J.W., Sandosham, A.A., Fong, Y.L., (1963) A Morphological Study of the Erythrocitic Parasites in Thick Blood Films, the Microscopic Diagnosis Of Human Malaria, pp. 20-117. , The Government Press, Kuala Lumpur Genton, B., D'Acremont, V., Rare, L., Baea, K., Reeder, J.C., Alpers, M.P., Muller, I., Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea (2008) PLoS Med., 5, pp. e127 Gil, L.H., Tada, M.S., Katsuragawa, T.H., Ribolla, P.E., da Silva, L.H., Urban and suburban malaria in Rondonia (Brazilian Western Amazon) II. Perennial transmissions with high anopheline densities are associated with human environmental changes (2007) Mem. Inst. Oswaldo Cruz, 102, pp. 271-276 Gupta, B.K., Sharma, K., Nayak, K.C., Agrawal, T.D., Binani, A., Purohit, V.P., Kochar, D.K., A case series of splenic infarction during acute malaria in northwest Rajasthan (2010) India. Trans. R. Soc. Trop. Med. Hyg., 104, pp. 81-83 Haldar, K., Mohandas, N., (2009) Malaria, Erythrocytic Infection, and Anemia, pp. 87-93. , Hematology Am. Soc. Hematol. Educ. Program, Washington Handayani, S., Chiu, D.T., Tjitra, E., Kuo, J.S., Lampah, D., Kenangalem, E., Renia, L., Russell, B., High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions (2009) J. Infect. Dis., 199, pp. 445-450 Karunaweera, N.D., Grau, G.E., Gamage, P., Carter, R., Mendis, K.N., Dynamics of fever and serum levels of tumor necrosis factor are closely associated during clinical paroxysms in Plasmodium vivax malaria (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 3200-3203 King, C.L., Adams, J.H., Xianli, J., Grimberg, B.T., McHenry, A.M., Greenberg, L.J., Siddiqui, A., Zimmerman, P.A., Fya/Fyb antigen polymorphism in human erythrocyte Duffy antigen affects susceptibility to Plasmodium vivax malaria (2011) Proc. Natl. Acad. Sci. USA, 108, pp. 20113-20118 Kochar, D.K., Das, A., Kochar, S.K., Saxena, V., Sirohi, P., Garg, S., Kochar, A., Gupta, V., Severe Plasmodium vivax malaria: a report on serial cases from Bikaner in northwestern India (2009) Am. J. Trop. Med. Hyg., 80, pp. 194-198 Kochar, D.K., Das, A., Kochar, A., Middha, S., Acharya, J., Tanwar, G.S., Gupta, A., Kochar, S.K., Thrombocytopenia in Plasmodium falciparum, Plasmodium vivax and mixed infection malaria: a study from Bikaner (Northwestern India) (2010) Platelets, 21, pp. 623-627 Lacerda, M.V., Alexandre, M.A., Santos, P.D., Arcanjo, A.R., Alecrim, W.D., Alecrim, M.G.C., Idiopathic thrombocytopenic purpura due to vivax malaria in the Brazilian Amazon (2004) Acta Trop., 90, pp. 187-190 Lacerda, M.V.G., Oliveira, S.L., Alecrim, M.G.C., Splenic hematoma in a patient with Plasmodium vivax malaria (2007) Rev. Soc. Bras. Med. Trop., 40, pp. 96-97 Lacerda, M.V., Mourao, M.P., Alexandre, M.A., Siqueira, A.M., Magalhaes, B.M., Martinez-Espinosa, F.E., Filho, F.S., Alecrim, M.G., Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature (2012) Malar. J., 11, p. 12 Lacerda, M.V., Fragoso, S.C., Alecrim, M.G., Alexandre, M.A., Magalhaes, B.M., Siqueira, A.M., Ferreira, L.C., Bassat, Q., Postmortem characterization of patients with clinical diagnosis of Plasmodium vivax malaria: to what extent does this parasite kill? (2012) Clin. Infect. Dis., 55, pp. e67-e74 Lampah, D.A., Yeo, T.W., Hardianto, S.O., Tjitra, E., Kenangalem, E., Sugiarto, P., Price, R.N., Anstey, N.M., Coma associated with microscopy-diagnosed Plasmodium vivax: a prospective study in Papua (2011) Indonesia. PLoS Negl. Trop. Dis., 5, pp. e1032 Lanca, E.F., Magalhaes, B.M., Vitor-Silva, S., Siqueira, A.M., Benzecry, S.G., Alexandre, M.A., O'Brien, C., Lacerda, M.V., Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon (2012) PLoS One, 7, pp. e35406 Leeson, H.S., Microscopic diagnosis of human malaria. A morphological-study of erythrocytic parasites (1957) R. Soc. Health J., 2, p. 694 Lubitz, J.M., Pathology of the ruptured spleen in acute vivax malaria (1949) Blood, 4, pp. 1168-1176 Manning, L., Rosanas-Urgell, A., Laman, M., Edoni, H., McLean, C., Mueller, I., Siba, P., Davis, T.M., A histopathologic study of fatal paediatric cerebral malaria caused by mixed Plasmodium falciparum/Plasmodium vivax infections (2012) Malar. J., 11, p. 107 Marti, M., Good, R.T., Rug, M., Knuepfer, E., Cowman, A.F., Targeting malaria virulence and remodeling proteins to the host erythrocyte (2004) Science, 306, pp. 1930-1933 Martinez-Espinosa, F.E., Daniel-Ribeiro, C.T., Alecrim, W.D., Malaria during pregnancy in a reference centre from the Brazilian Amazon: unexpected increase in the frequency of Plasmodium falciparum infections (2004) Mem. Inst. Oswaldo Cruz, 99, pp. 19-21 McGready, R., Davison, B.B., Stepniewska, K., Cho, T., Shee, H., Brockman, A., Udomsangpetch, R., Nosten, F., The effects of Plasmodium falciparum and P. vivax infections on placental histopathology in an area of low malaria transmission (2004) Am. J. Trop. Med. Hyg., 70, pp. 398-407 McGready, R., Lee, S., Wiladphaingern, J., Ashley, E., Rijken, M., Boel, M., Simpson, J., Nosten, F., Adverse effects of falciparum and vivax malaria and the safety of antimalarial treatment in early pregnancy: a population-based study (2011) Lancet Infect. Dis., 12, pp. 388-396 Mendis, K., Sina, B.J., Marchesini, P., Carter, R., The neglected burden of Plasmodium vivax malaria (2001) Am. J. Trop. Med. Hyg., 64, pp. 97-106 Mendonca, V.R., Luz, N.F., Santos, N.J., Borges, V.M., Goncalves, M.S., Andrade, B.B., Barral-Netto, M., Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria (2012) Infect. Immun., 80, pp. 1445-1454 Mercereau-Puijalon, O., Guillotte, M., Vigan-Womas, I., Rosetting in Plasmodium falciparum: a cytoadherence phenotype with multiple actors (2008) Transfus. Clin. Biol., 15, pp. 62-71 Mourao, L.C., Morais, C.G., Bueno, L.L., Jimenez, M.C., Soares, I.S., Fontes, C.J., Guimaraes Lacerda, M.V., Braga, E.M., Naturally acquired antibodies to Plasmodium vivax blood-stage vaccine candidates (PvMSP-1(19) and PvMSP-3alpha(359-798)) and their relationship with hematological features in malaria patients from the Brazilian Amazon (2012) Microbes Infect., 14, pp. 730-739 Mueller, I., Galinski, M.R., Baird, J.K., Carlton, J.M., Kochar, D.K., Alonso, P.L., del Portillo, H.A., Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite (2009) Lancet Infect. Dis., 9, pp. 555-566 Nosten, F., ter Kuile, F., Maelankirri, L., Decludt, B., White, N.J., Malaria during pregnancy in an area of unstable endemicity (1991) Trans. R. Soc. Trop. Med. Hyg., 85, pp. 424-429 Oliveira-Ferreira, J., Lacerda, M.V., Brasil, P., Ladislau, J.L., Tauil, P.L., Daniel-Ribeiro, C.T., Malaria in Brazil: an overview (2010) Malar. J., 9, p. 115 Parekh, F.K., Davison, B.B., Gamboa, D., Hernandez, J., Branch, O.H., Placental histopathologic changes associated with subclinical malaria infection and its impact on the fetal environment (2010) Am. J. Trop. Med. Hyg., 83, pp. 973-980 Price, R.N., Tjitra, E., Guerra, C.A., Yeung, S., White, N.J., Anstey, N.M., Vivax malaria: neglected and not benign (2007) Am. J. Trop. Med. Hyg., 77, pp. 79-87 Ramos Junior, W.M., Sardinha, J.F., Costa, M.R., Santana, M.S., Alecrim, M.G., Lacerda, M.V., Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon (2010) Braz. J. Infect. Dis., 14, pp. 410-412 Rijken, M.J., Papageorghiou, A.T., Thiptharakun, S., Kiricharoen, S., Dwell, S.L., Wiladphaingern, J., Pimanpanarak, M., McGready, R., Ultrasound evidence of early fetal growth restriction after maternal malaria infection (2012) PLoS One, 7, pp. e31411 Russell, B., Suwanarusk, R., Borlon, C., Costa, F.T., Chu, C.S., Rijken, M.J., Sriprawat, K., Renia, L., A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax (2011) Blood, 118, pp. e74-e81 Santana, M.S., Lacerda, M.V.G., Barbosa, M.G.V., Alecrim, W.D., Alecrim, M.G.C., Glucose-6-phosphate dehydrogenase deficiency in an endemic area for malaria in Manaus: a cross-sectional survey in the Brazilian Amazon (2009) PLoS One, 4, pp. e5259 Santos-Ciminera, P.D., Roberts, D.R., Alecrim, M.G., Costa, M.R., Quinnan, G.V., Malaria diagnosis and hospitalization trends (2007) Braz. Emerg. Infec. Dis., 13, pp. 1597-1600 Saraiva, M.G., Amorim, R.D., Moura, M.A., Martinez-Espinosa, F.E., Barbosa, M.G., Urban expansion and spatial distribution of malaria in the municipality of Manaus, State of Amazonas (2009) Rev. Soc. Bras. Med. Trop., 42, pp. 515-522 Silva, N.S., Silva-Nunes, M., Malafronte, R.S., Menezes, M.J., D'Arcadia, R.R., Komatsu, N.T., Scopel, K.K., Ferreira, M.U., Epidemiology and control of frontier malaria in Brazil: lessons from community-based studies in rural Amazonia (2010) Trans. R. Soc. Trop. Med. Hyg., 104, pp. 343-350 Siqueira, A.M., Alexandre, M.A., Mourao, M.P., Santos, V.S., Nagahashi-Marie, S.K., Alecrim, M.G., Lacerda, M.V., Severe rhabdomyolysis caused by Plasmodium vivax malaria in the Brazilian Amazon (2010) Am. J. Trop. Med. Hyg., 83, pp. 271-273 Suwanarusk, R., Cooke, B.M., Dondorp, A.M., Silamut, K., Sattabongkot, J., White, N.J., Udomsangpetch, R., The deformability of red blood cells parasitized by Plasmodium falciparum and P. vivax (2004) J. Infect. Dis., 189, pp. 190-194 Tan, L.K., Yacoub, S., Scott, S., Bhagani, S., Jacobs, M., Acute lung injury and other serious complications of Plasmodium vivax malaria (2008) Lancet Infect. Dis., 8, pp. 449-454 Tanwar, G.S., Khatri, P.C., Sengar, G.S., Kochar, A., Kochar, S.K., Middha, S., Tanwar, G., Kochar, D.K., Clinical profiles of 13 children with Plasmodium vivax cerebral malaria (2011) Ann. Trop. Paediatr., 31, pp. 351-356 Tjitra, E., Anstey, N.M., Sugiarto, P., Warikar, N., Kenangalem, E., Karyana, M., Lampah, D.A., Price, R.N., Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua (2008) Indonesia. PLoS Med., 5, pp. e128 Udomsanpetch, R., Thanikkul, K., Pukrittayakamee, S., White, N.J., Rosette formation by Plasmodium vivax (1995) Trans. R. Soc. Trop. Med. Hyg., 89, pp. 635-637 Udomsangpetch, R., Somsri, S., Panichakul, T., Chotivanich, K., Sirichaisinthop, J., Yang, Z., Cui, L., Sattabongkot, J., Short-term in vitro culture of field isolates of Plasmodium vivax using umbilical cord blood (2007) Parasitol. Int., 56, pp. 65-69 Valecha, N., Pinto, R.G., Turner, G.D., Kumar, A., Rodrigues, S., Dubhashi, N.G., Rodrigues, E., Baird, J.K., Histopathology of fatal respiratory distress caused by Plasmodium vivax malaria (2009) Am. J Trop. Med. Hyg., 81, pp. 758-762 Vitor-Silva, S., Reyes-Lecca, R.C., Pinheiro, T.R., Lacerda, M.V., Malaria is associated with poor school performance in an endemic area of the Brazilian Amazon (2009) Malar. J., 8, p. 230 (2011) World Malaria Report, , WHO, World Health Organisation, Geneva Wyler, D.J., Splenic functions in malaria (1983) Lymphology, 16, pp. 121-127 Yeo, T.W., Lampah, D.A., Tjitra, E., Piera, K., Gitawati, R., Kenangalem, E., Price, R.N., Anstey, N.M., Greater endothelial activation, Weibel-Palade body release and host inflammatory response to Plasmodium vivax, compared with Plasmodium falciparum: a prospective study in Papua (2010) Indonesia. J. Infect. Dis., 202, pp. 109-112