Experimental Model Of Smoking And Simulation Of Reflux With Acid And Pepsin In Rats [modelo Experimental De Tabagismo E Simulação De Refluxo Com ácido E Pepsina Em Ratos]

dc.creatorZen Jr. J.H.
dc.creatordel Negro A.
dc.creatorNeto J.A.C.
dc.creatorAraujo M.R.
dc.creatorAltemani A.M.
dc.creatorAndreollo N.A.
dc.date2012
dc.date2015-06-26T20:29:01Z
dc.date2015-11-26T14:25:30Z
dc.date2015-06-26T20:29:01Z
dc.date2015-11-26T14:25:30Z
dc.date.accessioned2018-03-28T21:28:01Z
dc.date.available2018-03-28T21:28:01Z
dc.identifier
dc.identifierActa Cirurgica Brasileira. , v. 27, n. 1, p. 1 - 5, 2012.
dc.identifier1028650
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-83155181953&partnerID=40&md5=99383640750d6550d967a4b86882b48f
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/96856
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/96856
dc.identifier2-s2.0-83155181953
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1245743
dc.descriptionPURPOSE: To develop experimental models to evaluate the effects of hydrochloric acid associated with the pepsin instilled in the mucosa of the upper esophagus and the sophagogastric junction of young male rats Wistar, simulating injury caused by astroesophageal reflux on the mucosa of aero-digestive tract in humans as well as the action of the risk exposure of mucosa to cigarette smoke. METHODS: Fifty young male Wistar rats divided in 5 groups with 10 animals each one, respectively simulating pharyngo-laryngeal reflux and gastroesophageal reflux, pharyngo-laryngeal reflux and smoking, smoking only, astroesophageal reflux and control group. RESULTS: The histopathologic studies no recorded neoplasias, only mild changes and no significant alterations. The hemo-oximetry (carboxyhemoglobin and methemoglobim) and CO2 concentration confirm that the animals were submitted to high intensity of exposure to carcinogens in tobacco and its derivatives. CONCLUSION: The experimental models were highly efficient, practical, easy to use and economical and can be employed in other similar studies to determine the harmful effects by smoking and reflux.
dc.description27
dc.description1
dc.description1
dc.description5
dc.descriptionde Stefani, E., Correa, P., Oreggia, F., Leiva, J., Rivero, S., Fernandez, G., Deneo-Pellegrini, H., Fontham, E., Risk factors for laryngeal cancer Cancer, 60 (12), pp. 3087-3091. , 198715
dc.descriptionKoufman, J.A., Burke, A.J., The etiology and pathogenesis of laryngeal carcinoma (1997) Otolaryngol Clin North Am, 30 (1), pp. 1-19
dc.descriptiondel Negro, A., Araújo, M.R., Tincani, A.J., Meirelles, L., Martins, A.S., Andreollo, N.A., Experimental carcinogenesis on the oropharyngeal mucosa of rats with hydrochloric acid, sodium nitrate and pepsin (2008) Acta Cir Bras, 23 (4), pp. 337-342
dc.descriptionCopper, M.P., Smit, C.F., Stanojcic, L.D., Devriese, P.P., Schouwenburg, P.F., Mathus-Vliegen, L.M.H., High incidence of laryngo-pharyngeal refux in patients with head and neck cancer (2000) Laryngoscope, 110, pp. 1007-1011
dc.descriptionWight, R., Paleri, V., Arullendran, P., Current theories for the development of nonsmoking and nondrinking laryngeal carcinoma (2003) Curr Opin Otolaryngol Head Neck Surg, 11 (2), pp. 73-77
dc.descriptionGalli, J., Cammarota, G., Calo, L., Agostino, S., D'ugo, D., Cianci, R., Almadori, G., The role of acid and alkaline refux in laryngeal squamous cell carcinoma (2002) Laryngoscope, 112 (10), pp. 1861-1865
dc.descriptionBacciu, A., Mercante, G., Ingegnoli, A., Bacciu, S., Ferri, T., Refux esophagitis as a possible risk factor in the development of pharyngolaryngeal squamous cell carcinoma (2003) Tumori, 89 (5), pp. 485-487
dc.descriptionOzlugedik, S., Yorulmaz, I., Gokcan, K., Is laryngopharyngeal refux an important risk factor in the development of laryngeal carcinoma? (2006) Eur Arch Otorhiolaryngol, 263 (4), pp. 339-343
dc.descriptionEl-Serag, H.B., Hepworth, E.J., Lee, P., Sonnenberg, A., Gastroesophageal refux disease is a risk factor for laryngeal and pharyngeal cancer (2001) Am J Gastroenterol, 96 (7), pp. 2013-2018
dc.descriptionWright, J.L., Churg, A., Cigarette smoke causes physiologic and morphologic changes of emphysema in the guinea pig (1990) Am Rev Respir Dis, 142 (6), pp. 1422-1428
dc.descriptionBiselli, P.J.C., (2008) Effect of Exposure to Cigarette Smoke and Diesel Oil Residue In the Lungs of Mice C57/B16 9 (Doctoral Thesis), , University of Sao Paulo: Faculty of Medicine
dc.descriptionQuinn, R., Comparing rat's to human's age: How old is my rat in people years? (2005) Nutrition, 21, p. 777
dc.descriptionD'agostini, F., Balansky, R.M., Izzotti, A., Lubet, R.A., Kelloff, G.J., de Flora, S., Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats (2001) Carcinogenesis, 22 (3), pp. 375-380
dc.descriptionShapiro, S.D., Animal models for COPD (2000) Chest, 117, pp. 223S-227S
dc.descriptionAndreollo, N.A., Lopes, L.R., Coelho-Neto, J.S., Gastroesophageal refux disease: What is the effectiveness of diagnostic tests? (2010) ABCD Arq Bras Cir Dig, 23 (1), pp. 6-10
dc.descriptionKoufman, J.A., Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease (2002) Ear Nose Throat J, 81 (9 SUPPL 2), pp. 7-9
dc.descriptionBulmer, D.M., Ali, M.S., Brownlee, I.A., Dettmar, D.W., Pearson, J.P., Laryngeal mucosa: Its susceptibility to acid and pepsin (2010) Laryngoscope, 120 (4), pp. 777-782
dc.descriptionFrancis, D.O., Maynard, C., Weymuller, E.A., Reiber, G., Merati, A.L., Yueh, B., Reevaluation of gastroesophageal refux disease as a risk factor for laryngeal (2011) Cancer, 121, pp. 102-105
dc.descriptionNurgalieva, Z.Z., Graham, D.Y., Dahlstrom, K.R., Wei, Q., Sturgis, E.M., A pilot study of Helicobacter pylori infection and risk of laryngopharyngeal cancer (2005) Head Neck, 27 (1), pp. 22-27
dc.descriptionWinter, J.W., Paterson, S., Scobie, G., Preston, T., McColl, K.E., N-nitrosamine generation from ingested nitrate via nitric oxide in subjects with and without gastroesophageal refux (2007) Gastroenterology, 133 (1), pp. 164-174
dc.descriptionModena, S.F., Meirelles, L.R., Araújo, M.R., Lopes, L.R., Andreollo, N.A., Role of nitrites in the genesis of adenocarcinoma associated with Barrett's esophagus (2009) In Vivo, 23 (6), pp. 919-923
dc.descriptionCherry, J., Margulies, S.I., Contact ulcer of the larynx (1968) Laryngoscope, 78 (11), pp. 1937-1940
dc.descriptionAdams, J., Heintz, P., Gross, N., Andersen, P., Everts, E., Wax, M., Cohen, J., Acid/pepsin promotion of carcinogenesis in the hamster cheek pouch (2000) Arch Otolaryngol Head Neck Surg, 126, pp. 405-409
dc.descriptionGoldberg, H.I., Dodds, W.J., Gee, S., Montgomery, C., Zboralske, F.F., Role of acid and pepsin in acute experimental esophagitis (1969) Gastroenterology, 56 (2), pp. 223-230
dc.descriptionLillemoe, K.D., Johnson, L.F., Harmon, J.W., Role of components of the gastroduodenal contents in experimental acid esophagitis (1982) Surgery, 92 (2), pp. 276-284
dc.languageen
dc.languagept
dc.publisher
dc.relationActa Cirurgica Brasileira
dc.rightsaberto
dc.sourceScopus
dc.titleExperimental Model Of Smoking And Simulation Of Reflux With Acid And Pepsin In Rats [modelo Experimental De Tabagismo E Simulação De Refluxo Com ácido E Pepsina Em Ratos]
dc.typeArtículos de revistas


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