Analysis Of The Physical Activity Effects And Measurement Of Pro-inflammatory Cytokines In Irradiated Lungs In Rats [análise Dos Efeitos Da Atividade Física E Mensuração De Citocinas Pró-inflamatórias Em Pulmões Irradiados Em Ratos]

dc.creatorBianchi R.C.G.
dc.creatorRopelle E.R.
dc.creatorKatashima C.K.
dc.creatorCarvalheira J.B.C.
dc.creatorLopes L.R.
dc.creatorAndreollo N.A.
dc.date2012
dc.date2015-06-26T20:29:01Z
dc.date2015-11-26T14:25:25Z
dc.date2015-06-26T20:29:01Z
dc.date2015-11-26T14:25:25Z
dc.date.accessioned2018-03-28T21:27:53Z
dc.date.available2018-03-28T21:27:53Z
dc.identifier
dc.identifierActa Cirurgica Brasileira. , v. 27, n. 3, p. 223 - 230, 2012.
dc.identifier1028650
dc.identifier10.1590/S0102-86502012000300004
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84859347914&partnerID=40&md5=f6e697a2a7df54fbb278d8e35e3b4f30
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/96853
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/96853
dc.identifier2-s2.0-84859347914
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1245709
dc.descriptionPURPOSE: To study if the pre-radiotherapy physical activity has radio-protective elements, by measuring the radio-induced activation of pro-inflammatory cytokines as interleukin-6 (il-6), transforming growth factor -β (tgf -β), tumor necrosis factor -α (tnf-α) and protein beta kinase β (ikkβ), through western blotting analysis. METHODS: A randomized study with 28 Wistar hannover rats, males, with a mean age of 90 days and weighing about 200 grams. The animals were divided into three groups: (GI, GII and GIII). GIII group were submitted to swimming for eight weeks (zero load, three times a week, about 30 minutes). Then, the groups (except the control group) were submitted to irradiation by cobalt therapy, single dose of 3.5 gray in the whole body. All animals were sacrificed by overdose of pentobarbital, according to the time for analysis of cytokines, and then a fragment of the lower lobe of the right lung went to western blotting analysis. RESULTS: The cytokines IKK β, TNF-α and IL-6 induced by radiation in the lung were lower in the exercised animals. However, exercise did not alter the radiation-induced increase in tgf-β. CONCLUSION: The results show a lower response in relation to inflammatory cytokines in the group that practiced the exercise pre-radiotherapy, showing that exercise can protect tissues from tissue damage due to irradiation.
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dc.languageen
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dc.relationActa Cirurgica Brasileira
dc.rightsaberto
dc.sourceScopus
dc.titleAnalysis Of The Physical Activity Effects And Measurement Of Pro-inflammatory Cytokines In Irradiated Lungs In Rats [análise Dos Efeitos Da Atividade Física E Mensuração De Citocinas Pró-inflamatórias Em Pulmões Irradiados Em Ratos]
dc.typeArtículos de revistas


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