Evaluation Of The Expression Of The Mgmt Gene In Normal And Neoplastic Tissue Of Patients With Colorectal Cancer [avaliação Da Expressão Do Gene Mgmt Nos Tecidos Normal E Neoplásico De Doentes Com Câncer Colorretal]

dc.creatorCordeiro A.T.
dc.creatorda Silva C.M.G.
dc.creatorBartchewsky Junior W.
dc.creatorRibeiro M.L.
dc.creatorMartinez C.A.R.
dc.date2012
dc.date2015-06-26T20:28:46Z
dc.date2015-11-26T14:24:45Z
dc.date2015-06-26T20:28:46Z
dc.date2015-11-26T14:24:45Z
dc.date.accessioned2018-03-28T21:27:05Z
dc.date.available2018-03-28T21:27:05Z
dc.identifier
dc.identifierRevista Do Colegio Brasileiro De Cirurgioes. , v. 39, n. 1, p. 48 - 53, 2012.
dc.identifier1006991
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84859519883&partnerID=40&md5=b6873973c47aa45c06994bd19e1b0850
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/96747
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/96747
dc.identifier2-s2.0-84859519883
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1245518
dc.descriptionObjective: To evaluate the expression of tissue repair gene MGMT by comparing normal and neoplastic colonic mucosa in patients with colorectal cancer (CRC). Methods: We studied 44 patients with colorectal cancer confirmed by histopathology. We excluded patients suspected of belonging to families with hereditary colorectal cancer (HNPCC and FAP) and patients with cancer of the lower or medium rectum treated with neoadjuvant chemoradiotherapy. The MGMT gene expression was assessed by the technique of polymerase chain reaction in real time (RT-PCR). The comparison of results for MGMT gene expression between normal and neoplastic tissues was made by paired Student's t test, adopting a significance level of 5% (p <0.05). Results: Tissue expression of the MGMT gene in all patients was lower in tumor tissue when compared to normal tissue (p = 0.002). Conclusion: The repair gene MGMT is less expressed in tumor tissue compared to normal tissues in patients with sporadic CRC.
dc.description39
dc.description1
dc.description48
dc.description53
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dc.languageen
dc.languagept
dc.publisher
dc.relationRevista do Colegio Brasileiro de Cirurgioes
dc.rightsaberto
dc.sourceScopus
dc.titleEvaluation Of The Expression Of The Mgmt Gene In Normal And Neoplastic Tissue Of Patients With Colorectal Cancer [avaliação Da Expressão Do Gene Mgmt Nos Tecidos Normal E Neoplásico De Doentes Com Câncer Colorretal]
dc.typeArtículos de revistas


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