Polymorphism On Codon 98 Of The Galectin-3 Gene Are Not Associated To Benign And Malignant Thyroid Tumors [o Polimorfismo No Códon 98 Do Gene De Galectina-3 Não Está Associado A Tumores Benignos E Malignos De Tiróide]

dc.creatorMartins L.
dc.creatorLeoni S.G.
dc.creatorFriguglietti C.U.M.
dc.creatorWard L.S.
dc.creatorKulcsar M.A.V.
dc.creatorKimura E.T.
dc.date2006
dc.date2015-06-30T18:07:27Z
dc.date2015-11-26T14:24:00Z
dc.date2015-06-30T18:07:27Z
dc.date2015-11-26T14:24:00Z
dc.date.accessioned2018-03-28T21:26:05Z
dc.date.available2018-03-28T21:26:05Z
dc.identifier
dc.identifierArquivos Brasileiros De Endocrinologia E Metabologia. , v. 50, n. 6, p. 1075 - 1081, 2006.
dc.identifier42730
dc.identifier10.1590/S0004-27302006000600014
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-33846445703&partnerID=40&md5=d637f3ef2b517234c21e7260df9cd33a
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/103165
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/103165
dc.identifier2-s2.0-33846445703
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1245277
dc.descriptionGalectin-3 is a multifunctional protein highly expressed in thyroid cancer. The galectin-3 gene (LGALS3) has several annotated candidates SNPs, however the relationship between galectin-3 SNPs and specific phenotypic variations relevant to health has not been evaluated. In this study, we investigated SNPs in the galectin-3 gene and a putative association with thyroid tumorigenesis. The presence of LGALS3 SNPs in thyroid carcinoma cell lines (NPA, TPC-1, WRO, ARO), thyroid tissues of 55 patients with multinodular goiter or papillary carcinoma diagnosis and lymphocytes of peripherical blood of 45 healthy individuals was evaluated by sequencing and SSCP. The analysis of LGALS3 coding sequence showed that the T98P site presents a great genotypic variation, since we observed both homozygous (AA or CC) and heterozygous (AC) patterns. In thyroid carcinoma cell lines, the genotype of NPA in the LGALS3 T98P site is CC, while TPC-1, WRO and ARO are AC. The genotypic frequency of T98P SNP observed in multinodular goiter (AC= 67%; AA= 23%; CC= 10%) and papillary carcinoma (AC= 68%; AA= 20%; CC= 12%) were similar to the frequency observed in the control population (AC= 60%, AA= 24%, CC=16%). In conclusion, no association between LGALS3 T98P genotype and the phenotype of the benign or malignant thyroid tumor was observed.
dc.description50
dc.description6
dc.description1075
dc.description1081
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dc.languagept
dc.publisher
dc.relationArquivos Brasileiros de Endocrinologia e Metabologia
dc.rightsaberto
dc.sourceScopus
dc.titlePolymorphism On Codon 98 Of The Galectin-3 Gene Are Not Associated To Benign And Malignant Thyroid Tumors [o Polimorfismo No Códon 98 Do Gene De Galectina-3 Não Está Associado A Tumores Benignos E Malignos De Tiróide]
dc.typeArtículos de revistas


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