Influence Of Lidocaine On The Neuromuscular Block Produced By Rocuronium. Study In Rat Phrenic-diaphragmatic Nerve Preparation [influência Da Lidocaína No Bloqueio Neuromuscular Produzido Pelo Rocurônio. Estudo Em Preparação Nervo Frênico-diafragma De Rato]

dc.creatorLoyola Y.C.S.
dc.creatorBraga A.D.F.D.A.
dc.creatorPoterio G.M.B.
dc.creatorDe Sousa S.R.
dc.creatorFernandes S.C.A.
dc.creatorBraga F.S.D.S.
dc.date2006
dc.date2015-06-30T18:05:36Z
dc.date2015-11-26T14:22:49Z
dc.date2015-06-30T18:05:36Z
dc.date2015-11-26T14:22:49Z
dc.date.accessioned2018-03-28T21:24:44Z
dc.date.available2018-03-28T21:24:44Z
dc.identifier
dc.identifierRevista Brasileira De Anestesiologia. , v. 56, n. 2, p. 147 - 156, 2006.
dc.identifier347094
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-33646850024&partnerID=40&md5=576972eb6867be1181b57d3ff0adad31
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/103054
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/103054
dc.identifier2-s2.0-33646850024
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1244936
dc.descriptionBACKGROUND AND OBJECTIVES: The action mechanism of local anesthetics (LA) on neuromuscular junction motivated several studies. When administered at low doses, they do not interfere on neuromuscular transmission. But high doses may compromise neuromuscular transmission and increase the effects of neuromuscular blockers. The objective of this study was to evaluate lidocaine interaction with rocuronium on rat diaphragm through its influence on neuromuscular block degree. METHODS: Rats, weighing between 250 and 300 g, were used. Preparation was set according to the technique described by Bulbring. Groups were formed (n = 5) according to the drug being studied: lidocaine - 20 μg.mL-1 (Group I); rocuronium - 4 μg.mL-1 (Group II), and rocuronium - 4 μg.mL-1 with lidocaine - 20 μg.mL-1 (Group III). The following items were assessed: 1) the extent of diaphragm muscle responses to indirect stimulation, both before and 60 minutes after adding lidocaine and a neuromuscular blocker; 2) membrane potentials (MP) and miniature end-plate potentials (MEPP); 3) the effectiveness of neostigmine, and 4) aminopyridine on neuromuscular blockage reversal. RESULTS: When administered separately, lidocaine did not alter the extent of muscular responses. With the previous use of lidocaine, rocuronium neuromuscular blockage was 82.8% ± 1.91%, with a significant difference (p = 0.0079) when compared to the group with isolated rocuronium (57.8% ± 1.9%). Blockage was both partially and fully reverted by neostigmine and 4-aminopyridine, respectively. Lidocaine did not alter membrane potential and caused an initial increase on MEPP, followed by a blockage. CONCLUSIONS: Lidocaine increases the neuromuscular blocking produced by rocuronium. MEPP modifications identify a presynaptic action. The complete antagonism of 4-aminopyridine indicates a presynaptic component. This idea is supported by the partial antagonism through neostigmine. © Sociedade Brasileira de Anestesiologia, 2006.
dc.description56
dc.description2
dc.description147
dc.description156
dc.descriptionDonati, F., Onset of action of relaxants (1988) Can J Anesth, 35, pp. S52-S58
dc.descriptionTelivuo, L., Katz, R.L., The effects of modern intravenous local analgesics on respiration during partial neuromuscular block in man (1970) Anesthesia, 25, pp. 30-35
dc.descriptionHamaya, Y., Dohi, S., Differences in cardiovascular response to airway stimulation at different sites and blockade of the response by lidocaine (2000) Anesthesiology, 93, pp. 95-103
dc.descriptionCardoso, L.S.M., Martins, C.R., Tardelli, M.A., Efeitos da lidocaína por via venosa sobre a farmacodinâmica do rocurônio (2005) Rev Bras Anestesiol, 55, pp. 371-380
dc.descriptionToft, P., Kirkegaard Nielsen, H., Severinsen, I., Effect of epidurally administered bupivacaine on atracurium-induced neuromuscular blockade (1990) Acta Anesthesiol Scand, 34, pp. 649-652
dc.descriptionTaivainen, T., Meretoja, O.A., Rosenberg, P.H., The effect of epidural bupivacaine on vecuronium-induced neuromuscular blockade in children (1994) Acta Anesthesiol Scand, 38, pp. 453-456
dc.descriptionYorukoglu, D., Asik, Y., Okten, F., Rocuronium combined with iv lidocaine for rapid tracheal intubation (2003) Acta Anesthesiol Scand, 47, pp. 583-587
dc.descriptionEngbaek, J., Viby-Mogensen, J., Can rocuronium replace succinylcholine in a rapid-sequence induction of anesthesia? (1999) Acta Anesthesiol Scand, 43, pp. 1-3
dc.descriptionAndrews, J.I., Kumar, N., Van Den Brom, R.H., A large simple randomized trial of rocuronium versus succinylcholine in rapidsequence induction of anesthesia along with propofol (1999) Acta Anesthesiol Scand, 43, pp. 4-8
dc.descriptionMatsuo, S., Rao, D.B., Chaudry, I., Interaction of muscle relaxants and local anesthetics at the neuromuscular junction (1978) Anesth Analg, 57, pp. 580-587
dc.descriptionUsubiaga, J.E., Wikinski, J.A., Morales, R.L., Interaction of intravenously administered procaine, lidocaine and succinylcholine in anesthetized subjects (1967) Anesth Analg, 46, pp. 39-45
dc.descriptionStraughan, D.W., The action of procaine at the neuromuscular junction (1971) J Pharm Pharmacol, 41, pp. 94-104
dc.descriptionSine, S.M., Taylor, P., Local anesthetics and histrionicotoxin are allosteric inhibitors of the acetylcholine receptor (1982) J Biol Chem, 257, pp. 8106-8114
dc.descriptionNeher, E., Steinbach, J.H., Local anesthetics transiently block currents through single acetylcholine-receptor channels (1978) J Physiol, 277, pp. 153-176
dc.descriptionPederneiras, S.G., Interação de drogas com relaxantes musculares (1988) Rev Bras Anestesiol, 38, pp. 63-73
dc.descriptionBulbring, E., Observation on the isolated phrenic nerve diaphragm preparation of the rat (1946) Br J Pharmacol, 1, pp. 38-61
dc.descriptionEllis, C.H., Wnuck, A.L., De Beer, E.J., Modifying actions of procaine on the myoneural blocking actions of succinylcholine, decamethonium and d-tubocurarine in dogs and cats (1953) Am J Physiol, 174, pp. 277-282
dc.descriptionCarpenter, R.L., Mulroy, M.F., Edrophonium antagonize combined lidocaine-pacuronium and verapamil-pancuronium neuromuscular blockade in cats (1986) Anesthesiology, 65, pp. 506-510
dc.descriptionHarrah, M.D., Way, W.L., Katzung, B.G., The interaction of d-tubocurarine with antiarrhythmic drugs (1970) Anesthesiology, 33, pp. 406-410
dc.descriptionMatthews, E.K., Quilliam, J.P., Effects of central depressant drugs upon acetylcholine release (1964) Br J Pharmacol Chemother, 22, pp. 415-440
dc.descriptionUsubiaga, J.E., Standaert, F., The effects of local anesthetics on motor nerve terminals (1968) J Pharmacol Exp Ther, 159, pp. 353-361
dc.descriptionRuff, R.L., The kinetics of local anesthetic blockade of end-plate channels (1982) Biophys J, 37, pp. 625-631
dc.descriptionCohen, J.B., Boyd, N.D., Shera, N.S., Interactions of Anesthetics with Nicotinic Postsynaptic Membranes Isolated from Torpedo Electric Tissue (1980) Molecular Mechanisms of Anesthesia. Progress in Anesthesiology, pp. 165-174. , Fink BR - New York: Raven Press
dc.descriptionSteinbach, A.B., Alteration of xylocaine (lidocaine) and its derivatives of the time course of the end plate potencial (1968) J Gen Physiol, 52, pp. 144-161
dc.descriptionYeh, J.Z., Oxford, G.S., Wu, C.H., Interactions of aminopyridines with potassium channels of squid axon membranes (1976) Biophys J, 16, pp. 77-81
dc.descriptionUlbricht, W., Wagner, H.H., Block of potassium channels of the nodal membrane by 4-aminopyridine and its partial removal on depolarization (1976) Pflugers Arch, 367, pp. 77-87
dc.descriptionBrazil, O.V., Fontana, M.D., Pavani, N.J., Effect of 4-aminopyridine on the postsynaptic action of polymyxin B (1989) Eur J Pharmacol, 159, pp. 47-51
dc.descriptionVital Brazil, O., Fontana, M.D., Pavani, N.J., Effect of 4-aminopyridine on end-plate receptor desensitization caused by carbachol (1982) Eur J Pharmacol, 86, pp. 199-205
dc.descriptionHarvey, A.L., Marshall, I.G., The facilitatory actions of aminopyridines and tetraethylammonium on neuromuscular transmission and muscle contractility in avian muscle (1977) Naunyn Schmiedebergs Arch Pharmacol, 299, pp. 53-60
dc.descriptionHarvey, A.L., Marshall, I.G., The actions of three diaminopyridines on the chick biventer cervicis muscle (1977) Eur J Pharmacol, 44, pp. 303-309
dc.descriptionBowman, W.C., Harvey, A.L., Marshall, I.G., The actions of aminopyridines on avian muscle (1977) Naunyn Schmiedebergs Arch Pharmacol, 297, pp. 99-103
dc.languagept
dc.languageen
dc.publisher
dc.relationRevista Brasileira de Anestesiologia
dc.rightsfechado
dc.sourceScopus
dc.titleInfluence Of Lidocaine On The Neuromuscular Block Produced By Rocuronium. Study In Rat Phrenic-diaphragmatic Nerve Preparation [influência Da Lidocaína No Bloqueio Neuromuscular Produzido Pelo Rocurônio. Estudo Em Preparação Nervo Frênico-diafragma De Rato]
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución