Influence Of Nifedipine On The Neuromuscular Block Produced By Atracurium And Cistracurium. Study In Rat Phrenic-diaphragmatic Nerve Preparation [influência Da Nifedipina No Bloqueio Neuromuscular Produzido Pelo Atracúrio E Pelo Cisatracúrio. Estudo Em Preparações Nervo Frênico-diafragma De Rato]

dc.creatorDe Sousa S.R.
dc.creatorBraga A.D.F.D.A.
dc.creatorPoterio G.M.B.
dc.creatorBraga F.S.D.S.
dc.creatorLoyola Y.C.S.
dc.creatorFernandes S.C.A.
dc.date2006
dc.date2015-06-30T18:05:35Z
dc.date2015-11-26T14:22:36Z
dc.date2015-06-30T18:05:35Z
dc.date2015-11-26T14:22:36Z
dc.date.accessioned2018-03-28T21:24:31Z
dc.date.available2018-03-28T21:24:31Z
dc.identifier
dc.identifierRevista Brasileira De Anestesiologia. , v. 56, n. 2, p. 157 - 167, 2006.
dc.identifier347094
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-33646849587&partnerID=40&md5=0ddb6c757cd38a0c4c597bce1149ce93
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/103053
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/103053
dc.identifier2-s2.0-33646849587
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1244877
dc.descriptionBACKGROUND AND OBJECTIVES: Calcium channel blockers may interact with neuromuscular blockers, increasing its effects. Research studies about this interaction display controversial results. In some studies these drugs produced neuromuscular blockage, or contracture, or no effect at all was proved over skeletal neuromuscular response. This study assessed the nifedipine effects over muscular responses and its possible interaction with neuromuscular blockers in rat diaphragm. METHODS: A number of 25 rats were used, weighing between 250 and 300 g and sacrificed under anesthesia with intraperitoneal pentobarbital (40 mg.kg-1). Preparation was mounted according to the technique described by Bulbring. Diaphragm was kept under tension, connected to an isometric transducer and subjected to an indirect stimulation of 0.1 Hz frequency. Diaphragm contractions were registered on a physiograph. In order to evaluate the effect of these drugs on neuromuscular transmission, they were added separately or associated to the preparation, on the following concentrations: nifedipine (4 μg.mL-1); atracurium (20 μg.mL-1); cistracurium (3 μg.mL-1). On phrenic-nerve preparation, the assessed items were: 1) the extent of diaphragm muscle response to indirect stimulation, before and 45 minutes after adding nifedipine and neuromuscular blockers separately and after the association of both drugs; 2) nifedipine effects on membrane potentials (MP) and miniature end-plate potentials (MEPP). RESULTS: Employed separately, nifedipine did not alter the extent of muscular responses, but it did significantly increase the neuromuscular blocking activity of atracurium and cistracurium. Nifedipine did not alter the membrane potential and caused an initial increase on MEPP frequencies, followed by a blockage. CONCLUSIONS: Nifedipine, on the employed concentration, increased the neuromuscular blockage produced by atracurium and cistracurium. Electrophysiological studies demonstrate the existence of presynaptic action and absence of depolarizing action over the muscle fiber. © Sociedade Brasileira de Anestesiologia, 2006.
dc.description56
dc.description2
dc.description157
dc.description167
dc.descriptionBikhazi, G.B., Flores, C., Foldes, F.F., The effect of verapamil and EGTA on the rat phrenic nerve hemidiaphragm preparation (1985) Anesth Analg, 64, pp. 505-508
dc.descriptionSalvador, A., Del Pozo, E., Carlos, R., Differential effects of calcium channel blocking agents on pancuronium and suxamethonium-induced neuromuscular blockade (1988) Br J Anaesth, 60, pp. 495-499
dc.descriptionKraynack, B.J., Lawson, N.W., Gintautas, J., Neuromuscular blocking action of verapamil in cats (1983) Can Anaesth Soc J, 30, pp. 242-247
dc.descriptionKraynack, B.J., Lawson, N.W., Gintautas, J., Effects of verapamil on indirect muscle twitch responses (1983) Anesth Analg, 62, pp. 827-830
dc.descriptionDel Pozo, E., Baeyens, J.M., Effects of calcium channel blockers on neuromuscular blockade induced by aminoglycoside antibiotics (1986) Eur J Pharmacol, 128, pp. 49-54
dc.descriptionBondi, A.Y., Effects of verapamil on excitation-contraction coupling in frog sartorius muscle (1978) J Pharmacol Exp Ther, 205, pp. 49-57
dc.descriptionSato, T., Ono, H., Demonstration of slow channel activation in skeletal muscle of the dog (1982) Eur J Pharmacol, 83, pp. 177-181
dc.descriptionAnderson, K.A., Marshall, R.J., Interactions between calcium entry blockers and vecuronium bromide in anaesthetized cats (1985) Br J Anaesth, 57, pp. 775-781
dc.descriptionBikhazi, G.B., Leung, I., Flores, C., Potentiation of neuromuscular blocking agents by calcium channel blockers in rats (1988) Anesth Analg, 67, pp. 1-8
dc.descriptionDurant, N.N., Nguyen, N., Katz, R.L., Potentiation of neuromuscular blockade by verapamil (1984) Anesthesiology, 60, pp. 298-303
dc.descriptionZalman, F., Perloff, J.K., Durant, N.N., Acute respiratory failure following intravenous verapamil in Duchenne's muscular dystrophy (1983) Am Heart J, 105, pp. 510-511
dc.descriptionIlias, W., Steinbereithner, K., Potentiation of pancuronium induced neuromuscular blockade by calcium channel blockers in vitro (1985) J Neural Transm, 64, pp. 285-293
dc.descriptionCarpenter, R.L., Mulroy, M.F., Edrophonium antagonize combined lidocaine-pacuronium and verapamil-pancuronium neuromuscular blockade in cats (1986) Anesthesiology, 65, pp. 506-510
dc.descriptionLawson, N.W., Kraynack, B.J., Gintautas, J., Neuromuscular and electrocardiographic responses to verapamil in dogs (1983) Anesth Analg, 62, pp. 50-54
dc.descriptionReves, J.G., Kissin, I., Lell, W.A., Calcium entry blockers: Uses and implications for anesthesiologists (1982) Anesthesiology, 57, pp. 504-518
dc.descriptionBulbring, E., Observation on the isolated phrenic nerve-diaphragm preparation of the rat (1946) Br J Pharmacol, 1, pp. 38-61
dc.descriptionSekerci, S., Tulunay, M., Interactions of calcium channel blockers with non-depolarising muscle relaxants in vitro (1996) Anaesthesia, 51, pp. 140-144
dc.descriptionWali, F.A., Interaction of verapamil with d-tubocurarine and cholinergic agonists at the avian neuromuscular junction (1987) Acta Anaesthesiol Scand, 31, pp. 15-20
dc.descriptionWali, F.A., Verapamil intensifies neuromuscular blockade produced by gallamine and pancuroniumat the chick neuromuscular junction (1986) Pharmacol Res Commun, 18, pp. 529-541
dc.descriptionWali, F.A., Interaction of verapamil with gallamine and pancuronium and reversal of combined neuromuscular blockade with neostigmine and edrophonium (1986) Eur J Anaesthesiol, 3, pp. 385-393
dc.descriptionJones, R.M., Cashman, J.N., Casson, W.R., Verapamil potentiation of neuromuscular blockade: Failure of reversal with neostigmine but prompt reversal with edrophonium (1985) Anesth Analg, 64, pp. 1021-1025
dc.descriptionVan Poorten, J.F., Dhasmana, K.M., Kuypers, R.S., Verapamil and reversal of vecuronium neuromuscular blockade (1984) Anesth Analg, 63, pp. 155-157
dc.descriptionNayler, W.G., Tissue-selectivity (1989) Calcium Antagonists, 2nd Ed, pp. 113-129. , Nayler WG - London: Harcourt Brace Jovanovich
dc.descriptionRibeiro, J.A., Dominguez, M.L., Goncalves, M.J., Purine effects at the neuromuscular junction and their modification by theophylline, imidazole and verapamil (1979) Arch Int Pharmacodyn Ther, 38, pp. 206-219
dc.descriptionStandaert, F.G., Dretchen, K.L., Cyclic nucleotides in neuromuscular transmission (1981) Anesth Analg, 60, pp. 91-99
dc.descriptionSingh, B.N., Ellrodt, G., Peter, C.T., Verapamil: A review of its pharmacological properties and therapeutic use (1978) Drugs, 15, pp. 169-197
dc.descriptionEsau, S.A., Interaction of theophylline, verapamil, and diltiazem on hamster diaphragm muscle force in vitro (1988) Am J Physiol, 254, pp. C365-C371
dc.descriptionDonaldson, P.L., Beam, K.G., Calcium currents in a fast-twitch skeletal muscle of the rat (1983) J Gen Physiol, 82, pp. 449-468
dc.descriptionWalsh, K.B., Bryant, S.H., Schwartz, A., Effect of calcium antagonist drugs on calcium currents in mammalian skeletal muscle fibers (1986) J Pharmacol Exp Ther, 236, pp. 403-407
dc.descriptionChiarandini, D.J., Bentley, P.J., The effects of verapamil on metabolism and contractility of the toad skeletal muscle (1973) J Pharmacol Exp Ther, 186, pp. 52-59
dc.languagept
dc.languageen
dc.publisher
dc.relationRevista Brasileira de Anestesiologia
dc.rightsfechado
dc.sourceScopus
dc.titleInfluence Of Nifedipine On The Neuromuscular Block Produced By Atracurium And Cistracurium. Study In Rat Phrenic-diaphragmatic Nerve Preparation [influência Da Nifedipina No Bloqueio Neuromuscular Produzido Pelo Atracúrio E Pelo Cisatracúrio. Estudo Em Preparações Nervo Frênico-diafragma De Rato]
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución