Effect Of Arginine Analogues On Rat Hind Paw Oedema And Mast Cell Activation In Vitro

dc.creatorGiraldelo C.M.M.
dc.creatorZappellini A.
dc.creatorMuscara M.N.
dc.creatorDe Luca I.M.S.
dc.creatorHyslop S.
dc.creatorCirino G.
dc.creatorZatz R.
dc.creatorDe Nucci G.
dc.creatorAntunes E.
dc.date1994
dc.date2015-06-26T17:27:44Z
dc.date2015-11-26T14:22:14Z
dc.date2015-06-26T17:27:44Z
dc.date2015-11-26T14:22:14Z
dc.date.accessioned2018-03-28T21:24:04Z
dc.date.available2018-03-28T21:24:04Z
dc.identifier
dc.identifierEuropean Journal Of Pharmacology. , v. 257, n. 1-2, p. 87 - 93, 1994.
dc.identifier142999
dc.identifier10.1016/0014-2999(94)90698-X
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0028292182&partnerID=40&md5=d7800cb98391bdcf5aefd9e70d690173
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/96354
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/96354
dc.identifier2-s2.0-0028292182
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1244759
dc.descriptionNitro-L-arginine methyl ester (0.15 μmol/paw) significantly reduced both bradykinin- and 5-hydroxytryptamine-induced rat paw oedema. At this dose, L-arginine (L-Arg), D-Arg and nitro-D-arginine methyl ester had no effect on the oedematogenic responses induced by these agents. Nitro-L-arginine methyl ester, nitro-D-arginine methyl ester, L-Arg, D-Arg L-arginine methyl ester and L-arginine ethyl ester, at the dose of 15 μmol/paw, significantly potentiated both bradykinin- and 5-hydroxytryptamine-induced oedema. This potentiation was not observed in animals treated with both mepyramine and methysergide or in animals chronically treated with compound 48/80. Nitro-L-arginine methyl ester (0.3-3 mM) and L-Arg (0.3-3 mM) released small amounts (<10%) of histamine from rat peritoneal mast cells when compared to compound 48/80-induced degranulation (>40%). Histamine release was quantified by radioimmunoassay since nitro-L-arginine methyl ester and L-Arg interfere with the fluorometric assay. The potentiation of paw oedema observed with higher doses of all arginine analogues is caused by in vivo mast cell degranulation and is probably due to the cationic charge of these substances. © 1994.
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dc.languageen
dc.publisher
dc.relationEuropean Journal of Pharmacology
dc.rightsfechado
dc.sourceScopus
dc.titleEffect Of Arginine Analogues On Rat Hind Paw Oedema And Mast Cell Activation In Vitro
dc.typeArtículos de revistas


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