Immunohistochemical Evidence For Myofibroblast-like Cells Associated With Liver Injury Induced By Aflatoxin B1 In Rainbow Trout (oncorhynchus Mykiss)

dc.creatorArana S.
dc.creatorAlves V.A.F.
dc.creatorSabino M.
dc.creatorTabata Y.A.
dc.creatorNonogaki S.
dc.creatorZaidan-Dagli M.-L.
dc.creatorHernandez-Blazquez F.J.
dc.date2014
dc.date2015-06-25T17:53:09Z
dc.date2015-11-26T14:22:10Z
dc.date2015-06-25T17:53:09Z
dc.date2015-11-26T14:22:10Z
dc.date.accessioned2018-03-28T21:24:00Z
dc.date.available2018-03-28T21:24:00Z
dc.identifier
dc.identifierJournal Of Comparative Pathology. W.b. Saunders Ltd, v. 150, n. 02/03/15, p. 258 - 265, 2014.
dc.identifier219975
dc.identifier10.1016/j.jcpa.2013.07.003
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84895871661&partnerID=40&md5=5bc4e7dc9c0143454dd9544546176e88
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86397
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86397
dc.identifier2-s2.0-84895871661
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1244741
dc.descriptionIn mammalian species, profibrogenic cells are activated to become myofibroblasts in response to liver damage. Few studies have examined hepatic myofibroblasts and their role in liver damage in teleosts. The aim of the present study was to investigate the involvement of myofibroblast-like cells in rainbow trout (Oncorhynchus mykiss) with hepatic damage induced by aflatoxin B1 (AFB1). Histopathological and immunohistochemical analyses characterized alterations in the liver stroma during the carcinogenic process. Anti-human α-smooth muscle actin (SMA) and anti-human desmin primary antibodies were used in immunohistochemistry. Only the anti-SMA reagent labelled cells in trout liver. In the livers of control fish, only smooth muscle in blood vessels and around bile ducts was labelled. In the livers from AFB1-treated fish, SMA-positive cells were present in the stroma surrounding neoplastic lesions and in areas of desmoplastic reaction. These observations indicate that in teleosts, as in mammals, the myofibroblast-like cell is involved in fibrosis associated with liver injury. Chronic liver injury induced in trout by aflatoxin may provide a useful model system for study of the evolution of such mechanisms. © 2013 Elsevier Ltd.
dc.description150
dc.description02/03/15
dc.description258
dc.description265
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dc.languageen
dc.publisherW.B. Saunders Ltd
dc.relationJournal of Comparative Pathology
dc.rightsfechado
dc.sourceScopus
dc.titleImmunohistochemical Evidence For Myofibroblast-like Cells Associated With Liver Injury Induced By Aflatoxin B1 In Rainbow Trout (oncorhynchus Mykiss)
dc.typeArtículos de revistas


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