Red Cell Membrane Protein Abnormalities In Hereditary Spherocytosis In Brazil

dc.creatorSaad S.T.O.
dc.creatorCosta F.F.
dc.creatorVicentim D.L.
dc.creatorSalles T.S.I.
dc.creatorPranke P.H.L.
dc.date1994
dc.date2015-06-26T17:27:25Z
dc.date2015-11-26T14:22:04Z
dc.date2015-06-26T17:27:25Z
dc.date2015-11-26T14:22:04Z
dc.date.accessioned2018-03-28T21:23:54Z
dc.date.available2018-03-28T21:23:54Z
dc.identifier
dc.identifierBritish Journal Of Haematology. , v. 88, n. 2, p. 295 - 299, 1994.
dc.identifier71048
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0028091593&partnerID=40&md5=0a19cdf8c8d8a4785e24ba3a4cd276b4
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/96266
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/96266
dc.identifier2-s2.0-0028091593
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1244717
dc.descriptionWe studied 14 kindred and nine unrelated patients from southeastern Brazil with the typical form of hereditary spherocytosis. Diagnosis was made on the basis of clinical features, presence of spherocytes on the peripheral blood smears and an abnormal osmotic fragility test. By densitometric tracing of SDS-PAGE stained by Coomassie blue, we detected isolated deficiency of spectrin in 39% of our patients, combined spectrin and ankyrin deficiency in 13%, and deficiency of band 3 in 13%. One of our patients presented ankyrin deficiency without spectrin reduction. Our data suggest that, despite ethnic differences among the Brazilian and European or North-American populations, these biochemical abnormalities in HS patients may be similar.
dc.description88
dc.description2
dc.description295
dc.description299
dc.languageen
dc.publisher
dc.relationBritish Journal of Haematology
dc.rightsfechado
dc.sourceScopus
dc.titleRed Cell Membrane Protein Abnormalities In Hereditary Spherocytosis In Brazil
dc.typeArtículos de revistas


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