Mouse Liver Microsomes (mlm) Protect Erythrocytes Against Trifluoperazine (tfp) Induced And Mechanical Hemolysis Which Are Due To Tfp Microsomal Transformation And To The Action Of An Unidentified Water-soluble Microsomal Factor (uf)

dc.creatorMeirelles N.C.
dc.creatorMalheiros S.V.P.
dc.creatorRuggiero A.C.
dc.creatorDegterev I.A.
dc.date1994
dc.date2015-06-26T17:27:14Z
dc.date2015-11-26T14:21:52Z
dc.date2015-06-26T17:27:14Z
dc.date2015-11-26T14:21:52Z
dc.date.accessioned2018-03-28T21:23:42Z
dc.date.available2018-03-28T21:23:42Z
dc.identifier
dc.identifierEuropean Journal Of Drug Metabolism And Pharmacokinetics. , v. 19, n. 4, p. 349 - 357, 1994.
dc.identifier3787966
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0028606573&partnerID=40&md5=d40b2fb85003690bec1bb14513361851
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/96221
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/96221
dc.identifier2-s2.0-0028606573
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1244660
dc.descriptionTrifluoperazine (TFP), a phenothiazine derivative, produces either hemolysis or protection of erythrocytes under isosmotic conditions in a dose-dependent manner. The hemolytic effect of TFP is abolished in the presence of mouse liver microsomes (MLM) which is due, in part, to drug incorporation, transformation and a MLM enzyme driven metabolism. An unidentified water-soluble factor (or factors) derived from MLM has been found to protect erythrocytes against both mechanical and TFP-induced isosmotic hemolysis.
dc.description19
dc.description4
dc.description349
dc.description357
dc.languageen
dc.publisher
dc.relationEuropean Journal of Drug Metabolism and Pharmacokinetics
dc.rightsfechado
dc.sourceScopus
dc.titleMouse Liver Microsomes (mlm) Protect Erythrocytes Against Trifluoperazine (tfp) Induced And Mechanical Hemolysis Which Are Due To Tfp Microsomal Transformation And To The Action Of An Unidentified Water-soluble Microsomal Factor (uf)
dc.typeArtículos de revistas


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