Oxidative Damage Of Mitochondria Induced By Fe(ii)citrate Is Potentiated By Ca2+ And Includes Lipid Peroxidation And Alterations In Membrane Proteins

dc.creatorCastilho R.F.
dc.creatorMeinicke A.R.
dc.creatorAlmeida A.M.
dc.creatorHermes-Lima M.
dc.creatorVercesi A.E.
dc.date1994
dc.date2015-06-26T17:27:08Z
dc.date2015-11-26T14:21:42Z
dc.date2015-06-26T17:27:08Z
dc.date2015-11-26T14:21:42Z
dc.date.accessioned2018-03-28T21:23:30Z
dc.date.available2018-03-28T21:23:30Z
dc.identifier
dc.identifierArchives Of Biochemistry And Biophysics. , v. 308, n. 1, p. 158 - 163, 1994.
dc.identifier39861
dc.identifier10.1006/abbi.1994.1022
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0028272219&partnerID=40&md5=b98431f085bd37673e158667ae2825db
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/96189
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/96189
dc.identifier2-s2.0-0028272219
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1244610
dc.descriptionIsolated rat liver mitochondria exposed to Fe(II)citrate undergo lipid peroxidation and alterations in membrane proteins. These processes were associated with irreversible decrease in membrane potential and mitochondrial swelling. Lipid peroxidation was evidenced by the production of thiobarbituric acid-reactive substances and also by the reaction of these products with membrane proteins, through the formation of Schiff bases. Alterations in membrane proteins were also characterized by the loss of specific proteins that could be recovered from the mitochondrial supernatant as shown by SDS-polyacrylamide gel electrophoresis. The degree of both lipid peroxidation and alterations in membrane proteins were diminished by EGTA, ruthenium red, or dibucaine. This strongly indicates that Ca2+ potentiates the oxidative damage of mitochondria exposed to Fe(II)citrate.
dc.description308
dc.description1
dc.description158
dc.description163
dc.languageen
dc.publisher
dc.relationArchives of Biochemistry and Biophysics
dc.rightsfechado
dc.sourceScopus
dc.titleOxidative Damage Of Mitochondria Induced By Fe(ii)citrate Is Potentiated By Ca2+ And Includes Lipid Peroxidation And Alterations In Membrane Proteins
dc.typeArtículos de revistas


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